Synthesis, mechanism of action, and biological evaluation of mitosenes

Mitosenes of both the pyrrolo- and pyrido[1,2-a]indole type have been prepared via modification of these heterotricyclic compounds. Several mitosenes have been studied for their reactions with nucleophiles under reductive conditions. The results of these experiments show that the biological activity...

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Veröffentlicht in:	Journal of medicinal chemistry 1989-07, Vol.32 (7), p.1612-1620
Hauptverfasser:	Orlemans, E. O. M, Verboom, W, Scheltinga, M. W, Reinhoudt, D. N, Lelieveld, P, Fiebig, H. H, Winterhalter, B. R, Double, J. A, Bibby, M. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Chemical Phenomena Chemistry Exact sciences and technology Female Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Humans Leukemia L1210 - pathology Mice Mice, Nude Mitomycin Mitomycins - pharmacology Neoplasm Transplantation Organic chemistry Preparations and properties Tumor Cells, Cultured - drug effects
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