Moles and site-specific risk of nonfamilial cutaneous malignant melanoma in women

We examined the relationship between self-reported mole counts and cutaneous melanoma with respect to anatomic site in 110 case and 231 control female nurses. Counts of moles on the lower leg were better predictors of melanoma risk than were counts of moles on the arm. The relative risk for the high...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1989-06, Vol.81 (12), p.948-952
Hauptverfasser:	Weinstock, M A, Colditz, G A, Willett, W C, Stampfer, M J, Bronstein, B R, Mihm, Jr, M C, Speizer, F E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arm Cohort Studies Female Humans Leg Melanoma - epidemiology Middle Aged Nevus, Pigmented - complications Nevus, Pigmented - epidemiology Risk Factors Skin Neoplasms - epidemiology Surveys and Questionnaires
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container_title	JNCI : Journal of the National Cancer Institute
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creator	Weinstock, M A Colditz, G A Willett, W C Stampfer, M J Bronstein, B R Mihm, Jr, M C Speizer, F E
description	We examined the relationship between self-reported mole counts and cutaneous melanoma with respect to anatomic site in 110 case and 231 control female nurses. Counts of moles on the lower leg were better predictors of melanoma risk than were counts of moles on the arm. The relative risk for the highest quintile of lower leg mole counts versus no lower leg moles was 4.2. Mole counts at each site (arm, thigh, and lower leg) were associated with risk of melanoma of the trunk and lower leg, but none were associated with the risk of melanoma of the upper extremity. The absence of direct site-specificity suggests that mole counts primarily indicate systemic melanoma risk, rather than direct risk from the moles themselves.
doi_str_mv	10.1093/jnci/81.12.948
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Counts of moles on the lower leg were better predictors of melanoma risk than were counts of moles on the arm. The relative risk for the highest quintile of lower leg mole counts versus no lower leg moles was 4.2. Mole counts at each site (arm, thigh, and lower leg) were associated with risk of melanoma of the trunk and lower leg, but none were associated with the risk of melanoma of the upper extremity. 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Counts of moles on the lower leg were better predictors of melanoma risk than were counts of moles on the arm. The relative risk for the highest quintile of lower leg mole counts versus no lower leg moles was 4.2. Mole counts at each site (arm, thigh, and lower leg) were associated with risk of melanoma of the trunk and lower leg, but none were associated with the risk of melanoma of the upper extremity. 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subjects	Adult Aged Arm Cohort Studies Female Humans Leg Melanoma - epidemiology Middle Aged Nevus, Pigmented - complications Nevus, Pigmented - epidemiology Risk Factors Skin Neoplasms - epidemiology Surveys and Questionnaires
title	Moles and site-specific risk of nonfamilial cutaneous malignant melanoma in women
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