Reduced cerebrospinal fluid B-endorphin levels in Rett syndrome
Cerebrospinal fluid (CSF) levels of B-endorphin (B-EP), B-lipotropin (B-LPH) and ACTH were measured in nine girls with Rett syndrome with features of autistic behavior (3.7-12.1 years of age) and in ten children with chronic leukemia (control group). The peptides were measured by radioimmunoassay, e...
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| Veröffentlicht in: | Child's nervous system 1989-04, Vol.5 (2), p.111-113 |
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| container_title | Child's nervous system |
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| creator | Genazzani, A R Zappella, M Nalin, A Hayek, Y Facchinetti, F |
| description | Cerebrospinal fluid (CSF) levels of B-endorphin (B-EP), B-lipotropin (B-LPH) and ACTH were measured in nine girls with Rett syndrome with features of autistic behavior (3.7-12.1 years of age) and in ten children with chronic leukemia (control group). The peptides were measured by radioimmunoassay, either directly in the sample (ACTH) or after Sephadex G-75 column chromatography, in order to eliminate interfering substances (B-LPH and B-EP). The CSF B-EP patient levels (20.8 +/- 13.1 fmol/ml, means +/- SD) were significantly lower than in age-matched controls (69.1 +/- 32.6, P less than 0.01), whereas the B-LPH and ACTH levels were in the control range. No correlations were found between the clinical findings and CSF neuropeptide concentrations. These data demonstrate a decrease in central opiate activity in girls with Rett syndrome. |
| doi_str_mv | 10.1007/BF00571121 |
| format | Article |
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The peptides were measured by radioimmunoassay, either directly in the sample (ACTH) or after Sephadex G-75 column chromatography, in order to eliminate interfering substances (B-LPH and B-EP). The CSF B-EP patient levels (20.8 +/- 13.1 fmol/ml, means +/- SD) were significantly lower than in age-matched controls (69.1 +/- 32.6, P less than 0.01), whereas the B-LPH and ACTH levels were in the control range. No correlations were found between the clinical findings and CSF neuropeptide concentrations. These data demonstrate a decrease in central opiate activity in girls with Rett syndrome.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/BF00571121</identifier><identifier>PMID: 2544265</identifier><language>eng</language><publisher>Germany</publisher><subject>Adrenocorticotropic Hormone - cerebrospinal fluid ; Autistic Disorder - cerebrospinal fluid ; beta-Endorphin - cerebrospinal fluid ; beta-Lipotropin - cerebrospinal fluid ; Child ; Child, Preschool ; Chronic Disease ; Female ; Humans ; Leukemia - cerebrospinal fluid ; Syndrome</subject><ispartof>Child's nervous system, 1989-04, Vol.5 (2), p.111-113</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-cbc1edd01162f50546eba04ae5ae4e966a1f7d735be9be862aa42dd606dff6123</citedby><cites>FETCH-LOGICAL-c282t-cbc1edd01162f50546eba04ae5ae4e966a1f7d735be9be862aa42dd606dff6123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2544265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Genazzani, A R</creatorcontrib><creatorcontrib>Zappella, M</creatorcontrib><creatorcontrib>Nalin, A</creatorcontrib><creatorcontrib>Hayek, Y</creatorcontrib><creatorcontrib>Facchinetti, F</creatorcontrib><title>Reduced cerebrospinal fluid B-endorphin levels in Rett syndrome</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><description>Cerebrospinal fluid (CSF) levels of B-endorphin (B-EP), B-lipotropin (B-LPH) and ACTH were measured in nine girls with Rett syndrome with features of autistic behavior (3.7-12.1 years of age) and in ten children with chronic leukemia (control group). The peptides were measured by radioimmunoassay, either directly in the sample (ACTH) or after Sephadex G-75 column chromatography, in order to eliminate interfering substances (B-LPH and B-EP). The CSF B-EP patient levels (20.8 +/- 13.1 fmol/ml, means +/- SD) were significantly lower than in age-matched controls (69.1 +/- 32.6, P less than 0.01), whereas the B-LPH and ACTH levels were in the control range. No correlations were found between the clinical findings and CSF neuropeptide concentrations. These data demonstrate a decrease in central opiate activity in girls with Rett syndrome.</description><subject>Adrenocorticotropic Hormone - cerebrospinal fluid</subject><subject>Autistic Disorder - cerebrospinal fluid</subject><subject>beta-Endorphin - cerebrospinal fluid</subject><subject>beta-Lipotropin - cerebrospinal fluid</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Leukemia - cerebrospinal fluid</subject><subject>Syndrome</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxDAUhYMo4zi6cS905UKo3qR5TFfiDI4KA8Kg65ImN1hJHyatMP_eyhRdnbP4OHA-Qi4p3FIAdbfaAAhFKaNHZE55lqWQCTgmc2BCpgo4nJKzGD8BqFiyfEZmTHDOpJiT-x3awaBNDAYsQxu7qtE-cX6obLJKsbFt6D6qJvH4jT4mY9th3ydx39jQ1nhOTpz2ES-mXJD3zePb-jndvj69rB-2qWFL1qemNBStBUolcwIEl1hq4BqFRo65lJo6ZVUmSsxLXEqmNWfWSpDWOUlZtiDXh90utF8Dxr6oq2jQe91gO8RC5cCV5HwEbw6gGc_EgK7oQlXrsC8oFL-2in9bI3w1rQ5ljfYPnfRkP-AhZEk</recordid><startdate>198904</startdate><enddate>198904</enddate><creator>Genazzani, A R</creator><creator>Zappella, M</creator><creator>Nalin, A</creator><creator>Hayek, Y</creator><creator>Facchinetti, F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198904</creationdate><title>Reduced cerebrospinal fluid B-endorphin levels in Rett syndrome</title><author>Genazzani, A R ; Zappella, M ; Nalin, A ; Hayek, Y ; Facchinetti, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-cbc1edd01162f50546eba04ae5ae4e966a1f7d735be9be862aa42dd606dff6123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adrenocorticotropic Hormone - cerebrospinal fluid</topic><topic>Autistic Disorder - cerebrospinal fluid</topic><topic>beta-Endorphin - cerebrospinal fluid</topic><topic>beta-Lipotropin - cerebrospinal fluid</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Humans</topic><topic>Leukemia - cerebrospinal fluid</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Genazzani, A R</creatorcontrib><creatorcontrib>Zappella, M</creatorcontrib><creatorcontrib>Nalin, A</creatorcontrib><creatorcontrib>Hayek, Y</creatorcontrib><creatorcontrib>Facchinetti, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Genazzani, A R</au><au>Zappella, M</au><au>Nalin, A</au><au>Hayek, Y</au><au>Facchinetti, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced cerebrospinal fluid B-endorphin levels in Rett syndrome</atitle><jtitle>Child's nervous system</jtitle><addtitle>Childs Nerv Syst</addtitle><date>1989-04</date><risdate>1989</risdate><volume>5</volume><issue>2</issue><spage>111</spage><epage>113</epage><pages>111-113</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Cerebrospinal fluid (CSF) levels of B-endorphin (B-EP), B-lipotropin (B-LPH) and ACTH were measured in nine girls with Rett syndrome with features of autistic behavior (3.7-12.1 years of age) and in ten children with chronic leukemia (control group). The peptides were measured by radioimmunoassay, either directly in the sample (ACTH) or after Sephadex G-75 column chromatography, in order to eliminate interfering substances (B-LPH and B-EP). The CSF B-EP patient levels (20.8 +/- 13.1 fmol/ml, means +/- SD) were significantly lower than in age-matched controls (69.1 +/- 32.6, P less than 0.01), whereas the B-LPH and ACTH levels were in the control range. No correlations were found between the clinical findings and CSF neuropeptide concentrations. These data demonstrate a decrease in central opiate activity in girls with Rett syndrome.</abstract><cop>Germany</cop><pmid>2544265</pmid><doi>10.1007/BF00571121</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0256-7040 |
| ispartof | Child's nervous system, 1989-04, Vol.5 (2), p.111-113 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adrenocorticotropic Hormone - cerebrospinal fluid Autistic Disorder - cerebrospinal fluid beta-Endorphin - cerebrospinal fluid beta-Lipotropin - cerebrospinal fluid Child Child, Preschool Chronic Disease Female Humans Leukemia - cerebrospinal fluid Syndrome |
| title | Reduced cerebrospinal fluid B-endorphin levels in Rett syndrome |
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