Estradiol-progesterone-induced growth of the rat dorsolateral prostate: Effects on protein phosphorylation
The combination of estradiol and progesterone can affect growth of the rat dorsolateral prostate by a mechanism that appears to be independent from androgen‐mediated activity. The effects of estradiol and progesterone on protein kinase activity and endogenous protein phosphorylation in the castrate...
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| Veröffentlicht in: | The Prostate 1989, Vol.14 (3), p.221-236 |
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| container_end_page | 236 |
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| container_issue | 3 |
| container_start_page | 221 |
| container_title | The Prostate |
| container_volume | 14 |
| creator | Belis, John A. Durham, John P. |
| description | The combination of estradiol and progesterone can affect growth of the rat dorsolateral prostate by a mechanism that appears to be independent from androgen‐mediated activity. The effects of estradiol and progesterone on protein kinase activity and endogenous protein phosphorylation in the castrate rat dorsolateral prostate were compared with androgenic effects on these intracellular events. Differences in protein kinase activity and protein phosphorylation were found with each type of hormonal therapy. Changes in protein kinase activity and protein phosphorylation produced by estradiol and progesterone in the rat dorsolateral prostate were not found in the rat ventral prostate, which was not affected by these hormones in the 28 day length of this study. |
| doi_str_mv | 10.1002/pros.2990140304 |
| format | Article |
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The effects of estradiol and progesterone on protein kinase activity and endogenous protein phosphorylation in the castrate rat dorsolateral prostate were compared with androgenic effects on these intracellular events. Differences in protein kinase activity and protein phosphorylation were found with each type of hormonal therapy. Changes in protein kinase activity and protein phosphorylation produced by estradiol and progesterone in the rat dorsolateral prostate were not found in the rat ventral prostate, which was not affected by these hormones in the 28 day length of this study.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/pros.2990140304</identifier><identifier>PMID: 2543964</identifier><identifier>CODEN: PRSTDS</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; BPH ; Calcium - metabolism ; Cyclic AMP - metabolism ; Dihydrotestosterone - pharmacology ; Estradiol - pharmacology ; Flutamide - pharmacology ; Fundamental and applied biological sciences. Psychology ; hormonal therapy ; Male ; Mammalian male genital system ; Morphology. Physiology ; Orchiectomy ; Organ Size - drug effects ; Phospholipids - metabolism ; Phosphorylation ; Progesterone - pharmacology ; Prostate - drug effects ; Prostate - enzymology ; Prostate - growth & development ; Prostate - metabolism ; protein kinase activity ; Protein Kinases - metabolism ; Proteins - metabolism ; Rats ; Rats, Inbred Strains ; Vertebrates: reproduction</subject><ispartof>The Prostate, 1989, Vol.14 (3), p.221-236</ispartof><rights>Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3664-75feb3401ff2caa794d15c4d8a907a8834be8dd0a3c0d1875659e4215061096e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpros.2990140304$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpros.2990140304$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19430198$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2543964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belis, John A.</creatorcontrib><creatorcontrib>Durham, John P.</creatorcontrib><title>Estradiol-progesterone-induced growth of the rat dorsolateral prostate: Effects on protein phosphorylation</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>The combination of estradiol and progesterone can affect growth of the rat dorsolateral prostate by a mechanism that appears to be independent from androgen‐mediated activity. The effects of estradiol and progesterone on protein kinase activity and endogenous protein phosphorylation in the castrate rat dorsolateral prostate were compared with androgenic effects on these intracellular events. Differences in protein kinase activity and protein phosphorylation were found with each type of hormonal therapy. Changes in protein kinase activity and protein phosphorylation produced by estradiol and progesterone in the rat dorsolateral prostate were not found in the rat ventral prostate, which was not affected by these hormones in the 28 day length of this study.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BPH</subject><subject>Calcium - metabolism</subject><subject>Cyclic AMP - metabolism</subject><subject>Dihydrotestosterone - pharmacology</subject><subject>Estradiol - pharmacology</subject><subject>Flutamide - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hormonal therapy</subject><subject>Male</subject><subject>Mammalian male genital system</subject><subject>Morphology. Physiology</subject><subject>Orchiectomy</subject><subject>Organ Size - drug effects</subject><subject>Phospholipids - metabolism</subject><subject>Phosphorylation</subject><subject>Progesterone - pharmacology</subject><subject>Prostate - drug effects</subject><subject>Prostate - enzymology</subject><subject>Prostate - growth & development</subject><subject>Prostate - metabolism</subject><subject>protein kinase activity</subject><subject>Protein Kinases - metabolism</subject><subject>Proteins - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: reproduction</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1PGzEQtapWkNKee0LaC9wWxmt7vYYTilJaCZWqH7TqxXLsMTFs1tTeiObf11EiUE89WGN53nsz75mQdxROKEBz-pBiPmmUAsqBAX9BJhSUrAG4eEkm0EioOWVyn7zO-Q6gcKDZI3uN4Ey1fELuZnlMxoXY10XqFvOIKQ5Yh8GtLLrqNsXHcVFFX40LrJIZKxdTjr0pONNXm_FjuZ9VM-_RjrmKw-ZxxFDqIuZy0rqgQxzekFfe9Bnf7uoB-f5-9m36ob66vvw4vbiqLWtbXkvhcc44UO8ba4xU3FFhueuMAmm6jvE5ds6BYRYc7aRohULeUAFtsd4iOyDHW92yx-9VcaSXIVvsezNgXGUtFXAuaFuAp1ugLS5yQq8fUliatNYU9CZdvbGnn9MtjMOd9Gq-RPeE38VZ-ke7vsnW9D6ZwYb8LKs4A6q6gjvf4h5Dj-v_jdWfv1x__WeLessO5bf-PLFNutetZFLoH58u9a-bn8BuplxL9hfmd6V7</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Belis, John A.</creator><creator>Durham, John P.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Estradiol-progesterone-induced growth of the rat dorsolateral prostate: Effects on protein phosphorylation</title><author>Belis, John A. ; Durham, John P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3664-75feb3401ff2caa794d15c4d8a907a8834be8dd0a3c0d1875659e4215061096e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BPH</topic><topic>Calcium - metabolism</topic><topic>Cyclic AMP - metabolism</topic><topic>Dihydrotestosterone - pharmacology</topic><topic>Estradiol - pharmacology</topic><topic>Flutamide - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hormonal therapy</topic><topic>Male</topic><topic>Mammalian male genital system</topic><topic>Morphology. Physiology</topic><topic>Orchiectomy</topic><topic>Organ Size - drug effects</topic><topic>Phospholipids - metabolism</topic><topic>Phosphorylation</topic><topic>Progesterone - pharmacology</topic><topic>Prostate - drug effects</topic><topic>Prostate - enzymology</topic><topic>Prostate - growth & development</topic><topic>Prostate - metabolism</topic><topic>protein kinase activity</topic><topic>Protein Kinases - metabolism</topic><topic>Proteins - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belis, John A.</creatorcontrib><creatorcontrib>Durham, John P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belis, John A.</au><au>Durham, John P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estradiol-progesterone-induced growth of the rat dorsolateral prostate: Effects on protein phosphorylation</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>1989</date><risdate>1989</risdate><volume>14</volume><issue>3</issue><spage>221</spage><epage>236</epage><pages>221-236</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><coden>PRSTDS</coden><abstract>The combination of estradiol and progesterone can affect growth of the rat dorsolateral prostate by a mechanism that appears to be independent from androgen‐mediated activity. The effects of estradiol and progesterone on protein kinase activity and endogenous protein phosphorylation in the castrate rat dorsolateral prostate were compared with androgenic effects on these intracellular events. Differences in protein kinase activity and protein phosphorylation were found with each type of hormonal therapy. Changes in protein kinase activity and protein phosphorylation produced by estradiol and progesterone in the rat dorsolateral prostate were not found in the rat ventral prostate, which was not affected by these hormones in the 28 day length of this study.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2543964</pmid><doi>10.1002/pros.2990140304</doi><tpages>16</tpages></addata></record> |
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| identifier | ISSN: 0270-4137 |
| ispartof | The Prostate, 1989, Vol.14 (3), p.221-236 |
| issn | 0270-4137 1097-0045 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences BPH Calcium - metabolism Cyclic AMP - metabolism Dihydrotestosterone - pharmacology Estradiol - pharmacology Flutamide - pharmacology Fundamental and applied biological sciences. Psychology hormonal therapy Male Mammalian male genital system Morphology. Physiology Orchiectomy Organ Size - drug effects Phospholipids - metabolism Phosphorylation Progesterone - pharmacology Prostate - drug effects Prostate - enzymology Prostate - growth & development Prostate - metabolism protein kinase activity Protein Kinases - metabolism Proteins - metabolism Rats Rats, Inbred Strains Vertebrates: reproduction |
| title | Estradiol-progesterone-induced growth of the rat dorsolateral prostate: Effects on protein phosphorylation |
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