WR 238605, Chloroquine, and their Combinations as Blood Schizonticides against a Chloroquine-Resistant Strain of Plasmodium vivax in Aotus Monkeys
The compound WR 238605 is a primaquine analog being developed by the U.S. Army as an antimalarial drug. Currently, there is no established treatment for Plasmodium vivax parasitemias that are not cured by chloroquine. This study tested WR 238605, chloroquine, and their combinations against a chloroq...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 1997-05, Vol.56 (5), p.508-510 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Obaldia, Nicanor, III Rossan, Richard N Cooper, Robert D Kyle, Dennis E Nuzum, Edwin O Rieckmann, Karl H Shanks, G. Dennis |
| description | The compound WR 238605 is a primaquine analog being developed by the U.S. Army as an antimalarial drug. Currently, there is no established treatment for Plasmodium vivax parasitemias that are not cured by chloroquine. This study tested WR 238605, chloroquine, and their combinations against a chloroquine-resistant strain of P. vivax (AMRU 1) in Aotus monkeys. A total dose of 3 mg/kg of WR 238605 given at a dosage of 1 mg/kg/day for three days cleared patent parasites in all eight monkeys but recrudescence of parasitemia occurred 15-25 days after initiation of treatment. A total dose of 9 mg/kg of WR 238605 over a three-day period cured all three monkeys of their infections. A total dose of 30 mg/kg of chloroquine did not clear patent infections in three monkeys, whereas a total dose of 60 mg/kg generally (two of three) cleared patent parasitemia but did not cure. Whereas total doses of 30 mg/kg of chloroquine or 3 mg/kg of WR 238605 given alone failed to cure, both drugs given in combination at these dosages cured two of three infections. These results indicate that WR 238605 may be an alternative treatment for chloroquine-resistant vivax malaria. |
| doi_str_mv | 10.4269/ajtmh.1997.56.508 |
| format | Article |
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A total dose of 30 mg/kg of chloroquine did not clear patent infections in three monkeys, whereas a total dose of 60 mg/kg generally (two of three) cleared patent parasitemia but did not cure. Whereas total doses of 30 mg/kg of chloroquine or 3 mg/kg of WR 238605 given alone failed to cure, both drugs given in combination at these dosages cured two of three infections. These results indicate that WR 238605 may be an alternative treatment for chloroquine-resistant vivax malaria.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.1997.56.508</identifier><identifier>PMID: 9180599</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Lawrence, KS: ASTMH</publisher><subject>Aminoquinolines - administration & dosage ; Aminoquinolines - therapeutic use ; Animals ; Antibiotics. Antiinfectious agents. 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Dennis</creatorcontrib><title>WR 238605, Chloroquine, and their Combinations as Blood Schizonticides against a Chloroquine-Resistant Strain of Plasmodium vivax in Aotus Monkeys</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>The compound WR 238605 is a primaquine analog being developed by the U.S. Army as an antimalarial drug. Currently, there is no established treatment for Plasmodium vivax parasitemias that are not cured by chloroquine. This study tested WR 238605, chloroquine, and their combinations against a chloroquine-resistant strain of P. vivax (AMRU 1) in Aotus monkeys. A total dose of 3 mg/kg of WR 238605 given at a dosage of 1 mg/kg/day for three days cleared patent parasites in all eight monkeys but recrudescence of parasitemia occurred 15-25 days after initiation of treatment. A total dose of 9 mg/kg of WR 238605 over a three-day period cured all three monkeys of their infections. A total dose of 30 mg/kg of chloroquine did not clear patent infections in three monkeys, whereas a total dose of 60 mg/kg generally (two of three) cleared patent parasitemia but did not cure. Whereas total doses of 30 mg/kg of chloroquine or 3 mg/kg of WR 238605 given alone failed to cure, both drugs given in combination at these dosages cured two of three infections. These results indicate that WR 238605 may be an alternative treatment for chloroquine-resistant vivax malaria.</description><subject>Aminoquinolines - administration & dosage</subject><subject>Aminoquinolines - therapeutic use</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimalarials - therapeutic use</subject><subject>Antiparasitic agents</subject><subject>Aotus trivirgatus</subject><subject>Biological and medical sciences</subject><subject>Chloroquine - administration & dosage</subject><subject>Chloroquine - therapeutic use</subject><subject>Drug Resistance</subject><subject>Drug Therapy, Combination</subject><subject>Human protozoal diseases</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Vivax - drug therapy</subject><subject>Medical sciences</subject><subject>Parasitemia - drug therapy</subject><subject>Parasitic diseases</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasmodium vivax</subject><subject>Protozoal diseases</subject><subject>Tropical medicine</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi1EVZbCA3BA8gE4NYudxHZ8LCv-VCoCtZU4Wo7tNC6J3WacLuUxeGKc7qrixmVGmvnNN5_0IfSKknVdcvleX6exX1MpxZrxNSPNE7SiteAF5TV7ilaEkLKQvBLP0HOAa0JoU1J6iA4lbQiTcoX-_DjHZdVwwo7xph_iFG9nH9wx1sHi1Ds_4U0cWx908jEA1oA_DDFafGF6_zuG5I23Ls-vtA-QsP5XpTh34CHpkPBFmjKAY4e_DxrGaP084jt_p3_hPD6JaQb8NYaf7h5eoINOD-Be7vsRuvz08XLzpTj79vl0c3JWmOw3Fa3khnAihe26hlFW2ZIx3lTU1NrWVjIqStbWrKXMyo4S0TmRi-GNa7hl1RF6t5O9Wdw6SGr0YNww6ODiDEpIUleCV_8FKc82yqbOIN2BZooAk-vUzeRHPd0rStSSl3rISy15KcZVzivfvN6Lz-3o7OPFPqC8f7PfazB66CYdjIdHrORCVNUi83aH9f6q3_rJKRj1MGRRqrbb7fLs4d1f2NisdQ</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Obaldia, Nicanor, III</creator><creator>Rossan, Richard N</creator><creator>Cooper, Robert D</creator><creator>Kyle, Dennis E</creator><creator>Nuzum, Edwin O</creator><creator>Rieckmann, Karl H</creator><creator>Shanks, G. Dennis</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>WR 238605, Chloroquine, and their Combinations as Blood Schizonticides against a Chloroquine-Resistant Strain of Plasmodium vivax in Aotus Monkeys</title><author>Obaldia, Nicanor, III ; Rossan, Richard N ; Cooper, Robert D ; Kyle, Dennis E ; Nuzum, Edwin O ; Rieckmann, Karl H ; Shanks, G. 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Dennis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>WR 238605, Chloroquine, and their Combinations as Blood Schizonticides against a Chloroquine-Resistant Strain of Plasmodium vivax in Aotus Monkeys</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>56</volume><issue>5</issue><spage>508</spage><epage>510</epage><pages>508-510</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>The compound WR 238605 is a primaquine analog being developed by the U.S. Army as an antimalarial drug. Currently, there is no established treatment for Plasmodium vivax parasitemias that are not cured by chloroquine. This study tested WR 238605, chloroquine, and their combinations against a chloroquine-resistant strain of P. vivax (AMRU 1) in Aotus monkeys. 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| subjects | Aminoquinolines - administration & dosage Aminoquinolines - therapeutic use Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - therapeutic use Antiparasitic agents Aotus trivirgatus Biological and medical sciences Chloroquine - administration & dosage Chloroquine - therapeutic use Drug Resistance Drug Therapy, Combination Human protozoal diseases Infectious diseases Malaria Malaria, Vivax - drug therapy Medical sciences Parasitemia - drug therapy Parasitic diseases Pharmacology. Drug treatments Plasmodium vivax Protozoal diseases Tropical medicine |
| title | WR 238605, Chloroquine, and their Combinations as Blood Schizonticides against a Chloroquine-Resistant Strain of Plasmodium vivax in Aotus Monkeys |
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