Direct Role of the Carboxy-Terminal Cell-Binding Domain of Fibronectin in Neural Crest Cell Motility
We have analyzed the interaction of neural crest cells with fragments of fibronectin corresponding to the different spliced variants of the COOH-terminal cell-binding domain (COOH-ter CBD). We have shown that this domain can support cell adhesion and migration and that both the IIICS and HepII regio...
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| Veröffentlicht in: | Experimental cell research 1997-05, Vol.233 (1), p.1-10 |
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| container_title | Experimental cell research |
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| creator | Beauvais-Jouneau, Alice Delouvée, Annie Craig, Susan E. Humphries, Martin J. Thiery, Jean-Paul Dufour, Sylvie |
| description | We have analyzed the interaction of neural crest cells with fragments of fibronectin corresponding to the different spliced variants of the COOH-terminal cell-binding domain (COOH-ter CBD). We have shown that this domain can support cell adhesion and migration and that both the IIICS and HepII regions are involved in these events. The rate of locomotion is high, although undirectional, compared to that of whole fibronectin. Interactions with the COOH-ter CBD are controled by α4β1and maybe other β1integrins and cell-surface proteoglycans. These receptors act cooperatively to mediate attachment, spreading, and migration on fibronectin. |
| doi_str_mv | 10.1006/excr.1997.3554 |
| format | Article |
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These receptors act cooperatively to mediate attachment, spreading, and migration on fibronectin.</description><subject>Animals</subject><subject>Cell Adhesion - genetics</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Cell Movement - genetics</subject><subject>Cells, Cultured</subject><subject>Fibronectins - genetics</subject><subject>Fibronectins - metabolism</subject><subject>Genetic Variation</subject><subject>Immunohistochemistry</subject><subject>Integrin beta1 - isolation & purification</subject><subject>Neural Crest - cytology</subject><subject>Neural Crest - physiology</subject><subject>Peptide Fragments - genetics</subject><subject>Peptide Fragments - metabolism</subject><subject>Quail - embryology</subject><issn>0014-4827</issn><issn>1090-2422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUhoMoc37ceif0yrvOkzTtmkvd_IKpIHod2uREI20zk07cvzfdhndCIITzvC8nDyFnFCYUoLjEH-UnVIjpJMtzvkfGFASkjDO2T8YAlKe8ZNNDchTCJwCUJS1GZCRoyaEQY6Ln1qPqkxfXYOJM0n9gMqt87X7W6Sv61nZVk8ywadJr22nbvSdz11a2G9hbW3vXxXR8xvOEKz_AHkO_iSSPrreN7dcn5MBUTcDT3X1M3m5vXmf36eL57mF2tUhVlok-5YKVGvKCY64FLQyrtVEaqKiLnAOqEjkT-RQKzAAYQzTasLI2VVbzwuRVdkwutr1L775WcQ3Z2qDiJlWHbhXkVADPMqARnGxB5V0IHo1cettWfi0pyEGrHLTKQasctMbA-a55Vbeo__Cdxzgvt3OM3_u26GVQFjuFeqNXamf_q_4Fco2G0w</recordid><startdate>19970525</startdate><enddate>19970525</enddate><creator>Beauvais-Jouneau, Alice</creator><creator>Delouvée, Annie</creator><creator>Craig, Susan E.</creator><creator>Humphries, Martin J.</creator><creator>Thiery, Jean-Paul</creator><creator>Dufour, Sylvie</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970525</creationdate><title>Direct Role of the Carboxy-Terminal Cell-Binding Domain of Fibronectin in Neural Crest Cell Motility</title><author>Beauvais-Jouneau, Alice ; Delouvée, Annie ; Craig, Susan E. ; Humphries, Martin J. ; Thiery, Jean-Paul ; Dufour, Sylvie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-4928d0564e5d916f2bdfcd019b6540ec8e4295706e30022eefdf28bfa3b46f5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Cell Adhesion - genetics</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Cell Movement - genetics</topic><topic>Cells, Cultured</topic><topic>Fibronectins - genetics</topic><topic>Fibronectins - metabolism</topic><topic>Genetic Variation</topic><topic>Immunohistochemistry</topic><topic>Integrin beta1 - isolation & purification</topic><topic>Neural Crest - cytology</topic><topic>Neural Crest - physiology</topic><topic>Peptide Fragments - genetics</topic><topic>Peptide Fragments - metabolism</topic><topic>Quail - embryology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beauvais-Jouneau, Alice</creatorcontrib><creatorcontrib>Delouvée, Annie</creatorcontrib><creatorcontrib>Craig, Susan E.</creatorcontrib><creatorcontrib>Humphries, Martin J.</creatorcontrib><creatorcontrib>Thiery, Jean-Paul</creatorcontrib><creatorcontrib>Dufour, Sylvie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beauvais-Jouneau, Alice</au><au>Delouvée, Annie</au><au>Craig, Susan E.</au><au>Humphries, Martin J.</au><au>Thiery, Jean-Paul</au><au>Dufour, Sylvie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct Role of the Carboxy-Terminal Cell-Binding Domain of Fibronectin in Neural Crest Cell Motility</atitle><jtitle>Experimental cell research</jtitle><addtitle>Exp Cell Res</addtitle><date>1997-05-25</date><risdate>1997</risdate><volume>233</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>0014-4827</issn><eissn>1090-2422</eissn><abstract>We have analyzed the interaction of neural crest cells with fragments of fibronectin corresponding to the different spliced variants of the COOH-terminal cell-binding domain (COOH-ter CBD). We have shown that this domain can support cell adhesion and migration and that both the IIICS and HepII regions are involved in these events. The rate of locomotion is high, although undirectional, compared to that of whole fibronectin. Interactions with the COOH-ter CBD are controled by α4β1and maybe other β1integrins and cell-surface proteoglycans. These receptors act cooperatively to mediate attachment, spreading, and migration on fibronectin.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9184069</pmid><doi>10.1006/excr.1997.3554</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4827 |
| ispartof | Experimental cell research, 1997-05, Vol.233 (1), p.1-10 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Cell Adhesion - genetics Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Movement - genetics Cells, Cultured Fibronectins - genetics Fibronectins - metabolism Genetic Variation Immunohistochemistry Integrin beta1 - isolation & purification Neural Crest - cytology Neural Crest - physiology Peptide Fragments - genetics Peptide Fragments - metabolism Quail - embryology |
| title | Direct Role of the Carboxy-Terminal Cell-Binding Domain of Fibronectin in Neural Crest Cell Motility |
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