Heparin Alters Transdermal Transport Associated with Electroporation

Short, high-voltage (HV; Uskin,max≈ 100V) pulses have been shown to increase rates of transdermal transport by several orders of magnitude via a mechanism hypothesized to involve electroporation. We show that heparin, a linear, highly charged macromolecule, significantly alters the molecular transpo...

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Veröffentlicht in:	Biochemical and biophysical research communications 1997-05, Vol.234 (3), p.637-640
Hauptverfasser:	Weaver, James C., Vanbever, Rita, Vaughan, Timothy E., Prausnitz, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Electroporation Fluoresceins - pharmacokinetics Heparin - pharmacology Humans In Vitro Techniques Rhodamines - pharmacokinetics Skin Absorption - drug effects
Online-Zugang:	Volltext
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