BIOLOGICAL ACTIVITIES OF IC201 ((3S, 8E)-1, 3-DIHYDROXY-8-DECEN-5-ONE), A LOW MOLECULAR WEIGHT IMMUNOMODULATOR PRODUCED BY STREPTOMYCES
IC201 was found in cultured broth of Streptomyces cirratus as an antitumor antibiotic which was effective in retarding growth of the established solid tumor of Ehrlich carcinoma by treatment starting 8 days after tumor inoculation. It retarded growth of the established solid tumor of IMC carcinoma b...
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| Veröffentlicht in: | Journal of antibiotics 1989/06/25, Vol.42(6), pp.952-959 |
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| container_title | Journal of antibiotics |
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| creator | MIZUTANI, SHIGETOSHI ODAI, HIDEHARU MASUDA, TORU IIJIMA, MASATOMI OSONO, MICHIYO HAMADA, MASA NAGANAWA, HIROSHI ISHIZUKA, MASAAKI TAKEUCHI, TOMIO |
| description | IC201 was found in cultured broth of Streptomyces cirratus as an antitumor antibiotic which was effective in retarding growth of the established solid tumor of Ehrlich carcinoma by treatment starting 8 days after tumor inoculation. It retarded growth of the established solid tumor of IMC carcinoma but had no cytotoxicity at 100 μg/ml. IC201 treatment kept NK cell activity of tumor-bearing mice at normal level and stimulated cytostatic activity of peritoneal macrophages. It stimulated phagocytosis of yeast and phorbol myristate acetateelicited superoxide production by peritoneal macrophages. The addition of IC201 to P388D1 cell cultures enhanced release of interleukin 1 (IL-1) into cultured supernatant but it affected lipopolysaccharide-induced IL-1 production. Although the addition to macrophage-depleted cultures did not show any stimulatory effect, mixed lymphocyte culture reaction was augmented in cultures using spleen cells as stimulator cells taken from mice given IC201. Results indicate that IC201 primarily activates macrophages and the activation may cause modulation of immune responses. |
| doi_str_mv | 10.7164/antibiotics.42.952 |
| format | Article |
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It retarded growth of the established solid tumor of IMC carcinoma but had no cytotoxicity at 100 μg/ml. IC201 treatment kept NK cell activity of tumor-bearing mice at normal level and stimulated cytostatic activity of peritoneal macrophages. It stimulated phagocytosis of yeast and phorbol myristate acetateelicited superoxide production by peritoneal macrophages. The addition of IC201 to P388D1 cell cultures enhanced release of interleukin 1 (IL-1) into cultured supernatant but it affected lipopolysaccharide-induced IL-1 production. Although the addition to macrophage-depleted cultures did not show any stimulatory effect, mixed lymphocyte culture reaction was augmented in cultures using spleen cells as stimulator cells taken from mice given IC201. Results indicate that IC201 primarily activates macrophages and the activation may cause modulation of immune responses.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.42.952</identifier><identifier>PMID: 2786863</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Adjuvants, Immunologic - analysis ; Adjuvants, Immunologic - biosynthesis ; Adjuvants, Immunologic - pharmacology ; Adjuvants, Immunologic - therapeutic use ; Animals ; Antibiotics, Antineoplastic - analysis ; Antibiotics, Antineoplastic - biosynthesis ; Antibiotics, Antineoplastic - pharmacology ; Antibiotics, Antineoplastic - therapeutic use ; Antineoplastic agents ; antitumor antibiotics ; Biological and medical sciences ; Carcinoma, Ehrlich Tumor - drug therapy ; Cell Line ; Cells, Cultured ; Fatty Alcohols - analysis ; Fatty Alcohols - biosynthesis ; Fatty Alcohols - pharmacology ; Fatty Alcohols - therapeutic use ; Female ; Fermentation ; General aspects ; IC201 ; Interleukin-1 - biosynthesis ; Killer Cells, Natural - immunology ; Lymphocytes - drug effects ; Macrophage Activation - drug effects ; macrophages ; Macrophages - drug effects ; Magnetic Resonance Spectroscopy ; Medical sciences ; Mice ; Mice, Inbred Strains ; Molecular Structure ; Phagocytosis - drug effects ; Pharmacology. Drug treatments ; Streptomyces - classification ; Streptomyces - metabolism</subject><ispartof>The Journal of Antibiotics, 1989/06/25, Vol.42(6), pp.952-959</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c637t-a0b7c8f68e559b7503116c7447748e1d0473d51cf91aee4d7db7a43b25fb05bb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6888214$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2786863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIZUTANI, SHIGETOSHI</creatorcontrib><creatorcontrib>ODAI, HIDEHARU</creatorcontrib><creatorcontrib>MASUDA, TORU</creatorcontrib><creatorcontrib>IIJIMA, MASATOMI</creatorcontrib><creatorcontrib>OSONO, MICHIYO</creatorcontrib><creatorcontrib>HAMADA, MASA</creatorcontrib><creatorcontrib>NAGANAWA, HIROSHI</creatorcontrib><creatorcontrib>ISHIZUKA, MASAAKI</creatorcontrib><creatorcontrib>TAKEUCHI, TOMIO</creatorcontrib><title>BIOLOGICAL ACTIVITIES OF IC201 ((3S, 8E)-1, 3-DIHYDROXY-8-DECEN-5-ONE), A LOW MOLECULAR WEIGHT IMMUNOMODULATOR PRODUCED BY STREPTOMYCES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>IC201 was found in cultured broth of Streptomyces cirratus as an antitumor antibiotic which was effective in retarding growth of the established solid tumor of Ehrlich carcinoma by treatment starting 8 days after tumor inoculation. It retarded growth of the established solid tumor of IMC carcinoma but had no cytotoxicity at 100 μg/ml. IC201 treatment kept NK cell activity of tumor-bearing mice at normal level and stimulated cytostatic activity of peritoneal macrophages. It stimulated phagocytosis of yeast and phorbol myristate acetateelicited superoxide production by peritoneal macrophages. The addition of IC201 to P388D1 cell cultures enhanced release of interleukin 1 (IL-1) into cultured supernatant but it affected lipopolysaccharide-induced IL-1 production. Although the addition to macrophage-depleted cultures did not show any stimulatory effect, mixed lymphocyte culture reaction was augmented in cultures using spleen cells as stimulator cells taken from mice given IC201. Results indicate that IC201 primarily activates macrophages and the activation may cause modulation of immune responses.</description><subject>Adjuvants, Immunologic - analysis</subject><subject>Adjuvants, Immunologic - biosynthesis</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Adjuvants, Immunologic - therapeutic use</subject><subject>Animals</subject><subject>Antibiotics, Antineoplastic - analysis</subject><subject>Antibiotics, Antineoplastic - biosynthesis</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Antibiotics, Antineoplastic - therapeutic use</subject><subject>Antineoplastic agents</subject><subject>antitumor antibiotics</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Ehrlich Tumor - drug therapy</subject><subject>Cell Line</subject><subject>Cells, Cultured</subject><subject>Fatty Alcohols - analysis</subject><subject>Fatty Alcohols - biosynthesis</subject><subject>Fatty Alcohols - pharmacology</subject><subject>Fatty Alcohols - therapeutic use</subject><subject>Female</subject><subject>Fermentation</subject><subject>General aspects</subject><subject>IC201</subject><subject>Interleukin-1 - biosynthesis</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphocytes - drug effects</subject><subject>Macrophage Activation - drug effects</subject><subject>macrophages</subject><subject>Macrophages - drug effects</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Molecular Structure</subject><subject>Phagocytosis - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Streptomyces - classification</subject><subject>Streptomyces - metabolism</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9u0zAUxiMEGmXwAkhIvkBok-rif7Gdyy7x1oimntKU0avISRzIlLYjTi94Al6bTI2q3XFzfOTvd853pM_zPmI0E5izr2bfN0Vz6JvSzRiZBT555U2wlBhixoPX3gQhgqGUBL313jn3iBAVVMgL74IIySWnE-_vTayX-i4O50swD7P4e5zFag30LYhDgjC4uqLrKZDqGuIpoDCKF9so1T-2UMJIhWoFfahX6noK5mCpH0CilyrcLOcpeFDx3SIDcZJsVjrR0fCZ6RTcp0MbqgjcbME6S9V9ppNtqNbvvTe1aZ39ML6X3uZWZeECjsfBklPRQ4MKUcqaS-v7QSF8RDHmpWBMCCYtrhATtPJxWQfYWMsqURXCMFoQvy6QXxT00vty2vvUHX4frevzXeNK27Zmbw9Hl4sAMYqI_18Q-5QzEZABJCew7A7OdbbOn7pmZ7o_OUb5c0z5i5hyRvIhpmHo07j9WOxsdR4Zcxn0z6NuXGnaujP7snFnjMshVMwG7NsJe3S9-WnPuukGs9a-dMYBl8_u_FSGI85U-ct0ud3Tf5UyrJA</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>MIZUTANI, SHIGETOSHI</creator><creator>ODAI, HIDEHARU</creator><creator>MASUDA, TORU</creator><creator>IIJIMA, MASATOMI</creator><creator>OSONO, MICHIYO</creator><creator>HAMADA, MASA</creator><creator>NAGANAWA, HIROSHI</creator><creator>ISHIZUKA, MASAAKI</creator><creator>TAKEUCHI, TOMIO</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>BIOLOGICAL ACTIVITIES OF IC201 ((3S, 8E)-1, 3-DIHYDROXY-8-DECEN-5-ONE), A LOW MOLECULAR WEIGHT IMMUNOMODULATOR PRODUCED BY STREPTOMYCES</title><author>MIZUTANI, SHIGETOSHI ; ODAI, HIDEHARU ; MASUDA, TORU ; IIJIMA, MASATOMI ; OSONO, MICHIYO ; HAMADA, MASA ; NAGANAWA, HIROSHI ; ISHIZUKA, MASAAKI ; TAKEUCHI, TOMIO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c637t-a0b7c8f68e559b7503116c7447748e1d0473d51cf91aee4d7db7a43b25fb05bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adjuvants, Immunologic - analysis</topic><topic>Adjuvants, Immunologic - biosynthesis</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Adjuvants, Immunologic - therapeutic use</topic><topic>Animals</topic><topic>Antibiotics, Antineoplastic - analysis</topic><topic>Antibiotics, Antineoplastic - biosynthesis</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Antibiotics, Antineoplastic - therapeutic use</topic><topic>Antineoplastic agents</topic><topic>antitumor antibiotics</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Ehrlich Tumor - drug therapy</topic><topic>Cell Line</topic><topic>Cells, Cultured</topic><topic>Fatty Alcohols - analysis</topic><topic>Fatty Alcohols - biosynthesis</topic><topic>Fatty Alcohols - pharmacology</topic><topic>Fatty Alcohols - therapeutic use</topic><topic>Female</topic><topic>Fermentation</topic><topic>General aspects</topic><topic>IC201</topic><topic>Interleukin-1 - biosynthesis</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lymphocytes - drug effects</topic><topic>Macrophage Activation - drug effects</topic><topic>macrophages</topic><topic>Macrophages - drug effects</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Molecular Structure</topic><topic>Phagocytosis - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Streptomyces - classification</topic><topic>Streptomyces - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MIZUTANI, SHIGETOSHI</creatorcontrib><creatorcontrib>ODAI, HIDEHARU</creatorcontrib><creatorcontrib>MASUDA, TORU</creatorcontrib><creatorcontrib>IIJIMA, MASATOMI</creatorcontrib><creatorcontrib>OSONO, MICHIYO</creatorcontrib><creatorcontrib>HAMADA, MASA</creatorcontrib><creatorcontrib>NAGANAWA, HIROSHI</creatorcontrib><creatorcontrib>ISHIZUKA, MASAAKI</creatorcontrib><creatorcontrib>TAKEUCHI, TOMIO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MIZUTANI, SHIGETOSHI</au><au>ODAI, HIDEHARU</au><au>MASUDA, TORU</au><au>IIJIMA, MASATOMI</au><au>OSONO, MICHIYO</au><au>HAMADA, MASA</au><au>NAGANAWA, HIROSHI</au><au>ISHIZUKA, MASAAKI</au><au>TAKEUCHI, TOMIO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BIOLOGICAL ACTIVITIES OF IC201 ((3S, 8E)-1, 3-DIHYDROXY-8-DECEN-5-ONE), A LOW MOLECULAR WEIGHT IMMUNOMODULATOR PRODUCED BY STREPTOMYCES</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1989</date><risdate>1989</risdate><volume>42</volume><issue>6</issue><spage>952</spage><epage>959</epage><pages>952-959</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>IC201 was found in cultured broth of Streptomyces cirratus as an antitumor antibiotic which was effective in retarding growth of the established solid tumor of Ehrlich carcinoma by treatment starting 8 days after tumor inoculation. It retarded growth of the established solid tumor of IMC carcinoma but had no cytotoxicity at 100 μg/ml. IC201 treatment kept NK cell activity of tumor-bearing mice at normal level and stimulated cytostatic activity of peritoneal macrophages. It stimulated phagocytosis of yeast and phorbol myristate acetateelicited superoxide production by peritoneal macrophages. The addition of IC201 to P388D1 cell cultures enhanced release of interleukin 1 (IL-1) into cultured supernatant but it affected lipopolysaccharide-induced IL-1 production. Although the addition to macrophage-depleted cultures did not show any stimulatory effect, mixed lymphocyte culture reaction was augmented in cultures using spleen cells as stimulator cells taken from mice given IC201. Results indicate that IC201 primarily activates macrophages and the activation may cause modulation of immune responses.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>2786863</pmid><doi>10.7164/antibiotics.42.952</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1989/06/25, Vol.42(6), pp.952-959 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Adjuvants, Immunologic - analysis Adjuvants, Immunologic - biosynthesis Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Animals Antibiotics, Antineoplastic - analysis Antibiotics, Antineoplastic - biosynthesis Antibiotics, Antineoplastic - pharmacology Antibiotics, Antineoplastic - therapeutic use Antineoplastic agents antitumor antibiotics Biological and medical sciences Carcinoma, Ehrlich Tumor - drug therapy Cell Line Cells, Cultured Fatty Alcohols - analysis Fatty Alcohols - biosynthesis Fatty Alcohols - pharmacology Fatty Alcohols - therapeutic use Female Fermentation General aspects IC201 Interleukin-1 - biosynthesis Killer Cells, Natural - immunology Lymphocytes - drug effects Macrophage Activation - drug effects macrophages Macrophages - drug effects Magnetic Resonance Spectroscopy Medical sciences Mice Mice, Inbred Strains Molecular Structure Phagocytosis - drug effects Pharmacology. Drug treatments Streptomyces - classification Streptomyces - metabolism |
| title | BIOLOGICAL ACTIVITIES OF IC201 ((3S, 8E)-1, 3-DIHYDROXY-8-DECEN-5-ONE), A LOW MOLECULAR WEIGHT IMMUNOMODULATOR PRODUCED BY STREPTOMYCES |
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