Determination of Paclitaxel and Related Taxanes in Bulk Drug and Injectable Dosage Forms by Reversed Phase Liquid Chromatography

Baseline separation of 15 taxanes including paclitaxel (Taxol) was achieved on pentafluorophenyl (PFP) HPLC columns. Methods using aqueous acetonitrile gradients on each of two commercial PFP columns were developed that are suitable for the determination of potency, content uniformity, and degradati...

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Veröffentlicht in:	Analytical chemistry (Washington) 1997-06, Vol.69 (11), p.2008-2016
Hauptverfasser:	Shao, Lillian Kuangjing, Locke, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents, Phytogenic - analysis Antineoplastic Agents, Phytogenic - metabolism Biological and medical sciences Bridged-Ring Compounds - analysis Bridged-Ring Compounds - chemistry Bridged-Ring Compounds - isolation & purification Bridged-Ring Compounds - metabolism Chromatography, High Pressure Liquid Dosage Forms Fluorobenzenes - chemistry General pharmacology Medical sciences Paclitaxel - analogs & derivatives Paclitaxel - analysis Paclitaxel - metabolism Pharmacology. Drug treatments Phenols - chemistry Reference Standards Reproducibility of Results Taxoids Thermodynamics
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