A pronounced thymic B cell deficiency in the spontaneously diabetic BB rat
In an attempt to elucidate the origin of the T cell lymphopenia and/or the beta-cell-specific autoimmunity observed in diabetes-prone Bio-Breeding (DP-BB) rats, a thymic cDNA library was subjected to differential screening with thymic cDNA probes of DP-BB rats and nonlymphopenic nondiabetic controls...
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| Veröffentlicht in: | The Journal of immunology (1950) 1997-06, Vol.158 (11), p.5554-5559 |
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| container_issue | 11 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 158 |
| creator | Tullin, S Farris, P Petersen, JS Hornum, L Jackerott, M Markholst, H |
| description | In an attempt to elucidate the origin of the T cell lymphopenia and/or the beta-cell-specific autoimmunity observed in diabetes-prone Bio-Breeding (DP-BB) rats, a thymic cDNA library was subjected to differential screening with thymic cDNA probes of DP-BB rats and nonlymphopenic nondiabetic controls. This approach resulted in the identification of a prominent lack of thymic B cells in DP-BB rats. This deficiency is distinct from a less pronounced peripheral B cell deficiency of different timing. The thymic B cell defect is linked to the lymphopenia trait on chromosome 4 and thereby with susceptibility to diabetes in crosses involving the DP-BB rat. In conclusion, our data suggest that the contribution of thymic B cells to the (negative) selection of thymocytes is inadequate in DP-BB rats, thus providing a plausible explanation for at least some of the spontaneous autoimmune phenomena in this animal model. |
| doi_str_mv | 10.4049/jimmunol.158.11.5554 |
| format | Article |
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In conclusion, our data suggest that the contribution of thymic B cells to the (negative) selection of thymocytes is inadequate in DP-BB rats, thus providing a plausible explanation for at least some of the spontaneous autoimmune phenomena in this animal model.</description><subject>Animals</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - pathology</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetes Mellitus, Type 1 - pathology</subject><subject>Immunohistochemistry</subject><subject>Lymphopenia</subject><subject>Rats</subject><subject>Rats, Inbred BB</subject><subject>Thymus Gland - immunology</subject><subject>Thymus Gland - pathology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr4zAUhUXpkKaPf9CCVqUbZ-61ZUtatqHTB4XZzKyFLF03Cn6klk3Ivx-HZEp3Xd3F-e7h8DF2jbAQIPTPdWiase3qBeZqgbjI81ycsDnmOSRFAcUpmwOkaYKykGfsPMY1ABSQihmbaSyEVjBnr_d803dtN7aOPB9WuyY4_sAd1TX3VAUXqHU7HtopIx43XTvYlrox1jvugy1p2PMPvLfDJftR2TrS1fFesL-_Hv8sn5O3308vy_u3xAlMh0QpQAe-Eqq0XkvtnSVJmVJl6bwvMXOaUu-rXJVYaayk1KqyJKzIpusou2C3h95p-MdIcTBNiPvBh2FGahApaP0tiAVkUqKaQHEAXd_F2FNlNn1obL8zCGbv2vx3bSbXBtHsXU9vN8f-sWzIfz4d5U753SFfhffVNvRkYmPreqLRbLfbr1X_AIZzi6g</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>Tullin, S</creator><creator>Farris, P</creator><creator>Petersen, JS</creator><creator>Hornum, L</creator><creator>Jackerott, M</creator><creator>Markholst, H</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970601</creationdate><title>A pronounced thymic B cell deficiency in the spontaneously diabetic BB rat</title><author>Tullin, S ; Farris, P ; Petersen, JS ; Hornum, L ; Jackerott, M ; Markholst, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-8801c0df48bad979dcae7e388bbcddb13c9e2ddf58b1f91f7798fae4a438face3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - pathology</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diabetes Mellitus, Type 1 - pathology</topic><topic>Immunohistochemistry</topic><topic>Lymphopenia</topic><topic>Rats</topic><topic>Rats, Inbred BB</topic><topic>Thymus Gland - immunology</topic><topic>Thymus Gland - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tullin, S</creatorcontrib><creatorcontrib>Farris, P</creatorcontrib><creatorcontrib>Petersen, JS</creatorcontrib><creatorcontrib>Hornum, L</creatorcontrib><creatorcontrib>Jackerott, M</creatorcontrib><creatorcontrib>Markholst, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tullin, S</au><au>Farris, P</au><au>Petersen, JS</au><au>Hornum, L</au><au>Jackerott, M</au><au>Markholst, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pronounced thymic B cell deficiency in the spontaneously diabetic BB rat</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>158</volume><issue>11</issue><spage>5554</spage><epage>5559</epage><pages>5554-5559</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>In an attempt to elucidate the origin of the T cell lymphopenia and/or the beta-cell-specific autoimmunity observed in diabetes-prone Bio-Breeding (DP-BB) rats, a thymic cDNA library was subjected to differential screening with thymic cDNA probes of DP-BB rats and nonlymphopenic nondiabetic controls. 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| identifier | ISSN: 0022-1767 |
| ispartof | The Journal of immunology (1950), 1997-06, Vol.158 (11), p.5554-5559 |
| issn | 0022-1767 1550-6606 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79042099 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals B-Lymphocytes - immunology B-Lymphocytes - pathology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Immunohistochemistry Lymphopenia Rats Rats, Inbred BB Thymus Gland - immunology Thymus Gland - pathology |
| title | A pronounced thymic B cell deficiency in the spontaneously diabetic BB rat |
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