Endogenous nitric oxide inhibits leukotriene B4 release from rat alveolar macrophages

Effects of endogenous nitric oxide (NO) on the release of mediators of the lipoxygenase and cyclo-oxygenase pathway from rat alveolar macrophages were studied. Alveolar macrophages, freshly isolated or after 18-h culture, were incubated in (amino acid-free) Krebs medium and labelled with [3H]arachid...

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Veröffentlicht in:	European journal of pharmacology 1997-05, Vol.326 (1), p.53-60
Hauptverfasser:	BRUNN, G, HEY, C, WESSLER, I, RACKE, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - metabolism Biological and medical sciences Calcimycin - pharmacology Cells, Cultured Chromatography, High Pressure Liquid Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology Inflammation Leukotriene B4 - metabolism Lipoxygenase - metabolism Macrophages, Alveolar - chemistry Macrophages, Alveolar - enzymology Macrophages, Alveolar - metabolism Molecular and cellular biology Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors omega-N-Methylarginine - pharmacology Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Sprague-Dawley
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