Preparation of 3-ketodesogestrel metabolites by microbial transformation and chemical synthesis

Specific microbial reactions were used for the preparation of metabolites of 3-ketodesogestrel (13-ethyl-17β-hydroxy-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-3-one, the active form of the progestagen desogestrel. Clostridium paraputrificum transformed 3-ketodesogestrel (KDG) to the 5β-dihydro a...

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Veröffentlicht in:	Steroids 1997-05, Vol.62 (5), p.437-443
Hauptverfasser:	Groh, Helmut, Schön, Renate, Ritzau, Michael, Kasch, Helmut, Undisz, Katrin, Hobe, Gerhard
Format:	Artikel
Sprache:	eng
Schlagworte:	3-ketodesogestrel Alicyclic compounds, terpenoids, prostaglandins, steroids Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology chemical synthesis Chemistry Clostridium - metabolism Desogestrel - metabolism Exact sciences and technology Fundamental and applied biological sciences. Psychology metabolite Methods. Procedures. Technologies microbial transformation Mycobacterium - metabolism NMR Organic chemistry Preparations and properties Progesterone Congeners - metabolism Rhodococcus - metabolism Steroids
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