Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c- neu oncogene

Transgenic mice carrying the activated c- neu oncogene under the control of the mouse mammary tumor virus (MMTV) long terminal repeat were produced. Epithelial hyperplasia of epididymis, seminal vesicles, and salivary glands, and dysplasia of harderian glands, were induced. Moreover, in females of o...

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Veröffentlicht in:	Cell 1989-06, Vol.57 (6), p.931-936
Hauptverfasser:	Bouchard, Louise, Lamarre, Louis, Tremblay, Patrick J., Jolicoeur, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Northern Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Gene Expression Regulation Mammary Neoplasms, Experimental - etiology Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - pathology Mice Mice, Transgenic Molecular and cellular biology Phenotype Proto-Oncogene Proteins - genetics Receptor, ErbB-2 Stochastic Processes Tissue Distribution
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