Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c- neu oncogene
Transgenic mice carrying the activated c- neu oncogene under the control of the mouse mammary tumor virus (MMTV) long terminal repeat were produced. Epithelial hyperplasia of epididymis, seminal vesicles, and salivary glands, and dysplasia of harderian glands, were induced. Moreover, in females of o...
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| Veröffentlicht in: | Cell 1989-06, Vol.57 (6), p.931-936 |
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| creator | Bouchard, Louise Lamarre, Louis Tremblay, Patrick J. Jolicoeur, Paul |
| description | Transgenic mice carrying the activated c-
neu oncogene under the control of the mouse mammary tumor virus (MMTV) long terminal repeat were produced. Epithelial hyperplasia of epididymis, seminal vesicles, and salivary glands, and dysplasia of harderian glands, were induced. Moreover, in females of our four lines, independent but multiple mammary tumors arose asynchronously, between 5 and 10 months of age, as stochastic events. Histologically, poorly differentiated adenocarcinomas, with intratumor necrosis and calcifications, arose adjacent to morphologically normal epithelium. High transgene expression was detected in all mammary tumors tested and in normal mammary glands before the appearance of the tumors. Together these results suggest that the expression of the activated c-
neu oncogene was necessary but not sufficient to induce malignant transformation of the mammary epithelial cells. These tumors appear to be an adequate model for human breast cancers overexpressing c-
neu. |
| doi_str_mv | 10.1016/0092-8674(89)90331-0 |
| format | Article |
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neu oncogene under the control of the mouse mammary tumor virus (MMTV) long terminal repeat were produced. Epithelial hyperplasia of epididymis, seminal vesicles, and salivary glands, and dysplasia of harderian glands, were induced. Moreover, in females of our four lines, independent but multiple mammary tumors arose asynchronously, between 5 and 10 months of age, as stochastic events. Histologically, poorly differentiated adenocarcinomas, with intratumor necrosis and calcifications, arose adjacent to morphologically normal epithelium. High transgene expression was detected in all mammary tumors tested and in normal mammary glands before the appearance of the tumors. Together these results suggest that the expression of the activated c-
neu oncogene was necessary but not sufficient to induce malignant transformation of the mammary epithelial cells. These tumors appear to be an adequate model for human breast cancers overexpressing c-
neu.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/0092-8674(89)90331-0</identifier><identifier>PMID: 2567634</identifier><identifier>CODEN: CELLB5</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blotting, Northern ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Mammary Neoplasms, Experimental - etiology ; Mammary Neoplasms, Experimental - genetics ; Mammary Neoplasms, Experimental - pathology ; Mice ; Mice, Transgenic ; Molecular and cellular biology ; Phenotype ; Proto-Oncogene Proteins - genetics ; Receptor, ErbB-2 ; Stochastic Processes ; Tissue Distribution</subject><ispartof>Cell, 1989-06, Vol.57 (6), p.931-936</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-564468f735dd1cb9c55aeccbe3056a9cc564c1c99d8bba93deb49087aec65a073</citedby><cites>FETCH-LOGICAL-c483t-564468f735dd1cb9c55aeccbe3056a9cc564c1c99d8bba93deb49087aec65a073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0092-8674(89)90331-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6852024$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2567634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouchard, Louise</creatorcontrib><creatorcontrib>Lamarre, Louis</creatorcontrib><creatorcontrib>Tremblay, Patrick J.</creatorcontrib><creatorcontrib>Jolicoeur, Paul</creatorcontrib><title>Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c- neu oncogene</title><title>Cell</title><addtitle>Cell</addtitle><description>Transgenic mice carrying the activated c-
neu oncogene under the control of the mouse mammary tumor virus (MMTV) long terminal repeat were produced. Epithelial hyperplasia of epididymis, seminal vesicles, and salivary glands, and dysplasia of harderian glands, were induced. Moreover, in females of our four lines, independent but multiple mammary tumors arose asynchronously, between 5 and 10 months of age, as stochastic events. Histologically, poorly differentiated adenocarcinomas, with intratumor necrosis and calcifications, arose adjacent to morphologically normal epithelium. High transgene expression was detected in all mammary tumors tested and in normal mammary glands before the appearance of the tumors. Together these results suggest that the expression of the activated c-
neu oncogene was necessary but not sufficient to induce malignant transformation of the mammary epithelial cells. These tumors appear to be an adequate model for human breast cancers overexpressing c-
neu.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Mammary Neoplasms, Experimental - etiology</subject><subject>Mammary Neoplasms, Experimental - genetics</subject><subject>Mammary Neoplasms, Experimental - pathology</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Molecular and cellular biology</subject><subject>Phenotype</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Receptor, ErbB-2</subject><subject>Stochastic Processes</subject><subject>Tissue Distribution</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFEEQhhtR4hr9Bwp9EImHMd3T3xdBQvyABA9GT0LTU1OTtOxMb7pnhPx7e9xlj3qqw_vUS_EUIS85e8cZ1-eMubax2sgz6946JgRv2COy4cyZRnLTPiabI_KUPCvlF2PMKqVOyEmrtNFCbsjPb3OCu1DmCDTsdhhymABpGugYxjHkBzovY8qFxonONSu3OFV0jBWCkPNDnG7pfIf0-vrmxzk0dMKFpglS5fA5eTKEbcEXh3lKvn-8vLn43Fx9_fTl4sNVA9KKuVFaSm0HI1Tfc-gcKBUQoEPBlA4OoALAwbnedl1wosdOOmZNhbQKzIhT8mbfu8vpfsEy-zEWwO02TJiW4k21Y4RW_wW5arVszdoo9yDkVErGwe9yXHV4zvxq369q_arWW-f_2vesrr069C_diP1x6aC75q8PeSgQtsMqO5Yjpq1qWbti7_cYVmm_I2ZfIGL9Sx8zwuz7FP99xx_2b6DY</recordid><startdate>19890616</startdate><enddate>19890616</enddate><creator>Bouchard, Louise</creator><creator>Lamarre, Louis</creator><creator>Tremblay, Patrick J.</creator><creator>Jolicoeur, Paul</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19890616</creationdate><title>Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c- neu oncogene</title><author>Bouchard, Louise ; Lamarre, Louis ; Tremblay, Patrick J. ; Jolicoeur, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-564468f735dd1cb9c55aeccbe3056a9cc564c1c99d8bba93deb49087aec65a073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Mammary Neoplasms, Experimental - etiology</topic><topic>Mammary Neoplasms, Experimental - genetics</topic><topic>Mammary Neoplasms, Experimental - pathology</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Molecular and cellular biology</topic><topic>Phenotype</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Receptor, ErbB-2</topic><topic>Stochastic Processes</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouchard, Louise</creatorcontrib><creatorcontrib>Lamarre, Louis</creatorcontrib><creatorcontrib>Tremblay, Patrick J.</creatorcontrib><creatorcontrib>Jolicoeur, Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouchard, Louise</au><au>Lamarre, Louis</au><au>Tremblay, Patrick J.</au><au>Jolicoeur, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c- neu oncogene</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1989-06-16</date><risdate>1989</risdate><volume>57</volume><issue>6</issue><spage>931</spage><epage>936</epage><pages>931-936</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><coden>CELLB5</coden><abstract>Transgenic mice carrying the activated c-
neu oncogene under the control of the mouse mammary tumor virus (MMTV) long terminal repeat were produced. Epithelial hyperplasia of epididymis, seminal vesicles, and salivary glands, and dysplasia of harderian glands, were induced. Moreover, in females of our four lines, independent but multiple mammary tumors arose asynchronously, between 5 and 10 months of age, as stochastic events. Histologically, poorly differentiated adenocarcinomas, with intratumor necrosis and calcifications, arose adjacent to morphologically normal epithelium. High transgene expression was detected in all mammary tumors tested and in normal mammary glands before the appearance of the tumors. Together these results suggest that the expression of the activated c-
neu oncogene was necessary but not sufficient to induce malignant transformation of the mammary epithelial cells. These tumors appear to be an adequate model for human breast cancers overexpressing c-
neu.</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>2567634</pmid><doi>10.1016/0092-8674(89)90331-0</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Blotting, Northern Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Gene Expression Regulation Mammary Neoplasms, Experimental - etiology Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - pathology Mice Mice, Transgenic Molecular and cellular biology Phenotype Proto-Oncogene Proteins - genetics Receptor, ErbB-2 Stochastic Processes Tissue Distribution |
| title | Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c- neu oncogene |
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