Lack of effect of granulocyte-macrophage colony-stimulating factor on secretion of interferon-tau, other proteins, and prostaglandin E2 by the bovine and ovine conceptus
Three experiments tested the effects of recombinant bovine granulocyte-macrophage colony-stimulating factor (rbGM-CSF) on the preimplantation bovine and ovine conceptus. There was no effect of rbGM-CSF on the secretion of total radiolabeled protein in conditioned medium, immunoreactive interferon-ta...
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| Veröffentlicht in: | Domestic animal endocrinology 1997-05, Vol.14 (3), p.193-197 |
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| container_title | Domestic animal endocrinology |
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| creator | de Moraes, A A Davidson, J A Fleming, J G Bazer, F W Edwards, J L Betts, J G Hansen, P J |
| description | Three experiments tested the effects of recombinant bovine granulocyte-macrophage colony-stimulating factor (rbGM-CSF) on the preimplantation bovine and ovine conceptus. There was no effect of rbGM-CSF on the secretion of total radiolabeled protein in conditioned medium, immunoreactive interferon-tau (IFN tau), antiviral activity, or prostaglandin E2 from Day 16-18 bovine conceptuses cultured for 24 hr with, [3H]leucine and +/- 10 ng/ml rbGM-CSF. Similarly, there was no effect of 1 ng/ml rbGM-CSF on the secretion of total radiolabeled protein. IFN tau, or antiviral activity from Day 17 ovine conceptuses. There was also no beneficial effect of 1 or 10 ng/ml rbGM-CSF on the presence of immunoreactive IFN tau in conditioned medium from in vitro-produced bovine blastocysts at Day 7-8 after fertilization. Results indicate that IFN tau secretion from bovine and ovine conceptuses are unresponsive to rbGM-CSF at the concentrations tested. |
| doi_str_mv | 10.1016/S0739-7240(97)00002-7 |
| format | Article |
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There was no effect of rbGM-CSF on the secretion of total radiolabeled protein in conditioned medium, immunoreactive interferon-tau (IFN tau), antiviral activity, or prostaglandin E2 from Day 16-18 bovine conceptuses cultured for 24 hr with, [3H]leucine and +/- 10 ng/ml rbGM-CSF. Similarly, there was no effect of 1 ng/ml rbGM-CSF on the secretion of total radiolabeled protein. IFN tau, or antiviral activity from Day 17 ovine conceptuses. There was also no beneficial effect of 1 or 10 ng/ml rbGM-CSF on the presence of immunoreactive IFN tau in conditioned medium from in vitro-produced bovine blastocysts at Day 7-8 after fertilization. Results indicate that IFN tau secretion from bovine and ovine conceptuses are unresponsive to rbGM-CSF at the concentrations tested.</description><subject>Animals</subject><subject>Blastocyst - drug effects</subject><subject>Blastocyst - metabolism</subject><subject>Cattle</subject><subject>Culture Media, Conditioned</subject><subject>Dinoprostone - metabolism</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology</subject><subject>Insemination, Artificial</subject><subject>Interferon Type I</subject><subject>Interferon-gamma - metabolism</subject><subject>Organ Culture Techniques</subject><subject>Pregnancy Proteins - metabolism</subject><subject>Proteins - metabolism</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Swine</subject><issn>0739-7240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kdtOAyEQhrnQeKg-gglXRpOuwrK7lEvT1EPSxAv1mrB0qOguVGBN-ki-pfSQzs38TL4ZJvMjdEXJHSW0uX8jnImClxW5EfyW5CgLfoTODuVTdB7jV67zzJ-gE0E5FZyfob-50t_YGwzGgE4btQzKDZ3X6wRFr3Twq0-1BKx95926iMn2Q6eSdUtslE4-YO9wBB0g2azyAOsSBAPBuyKpYYx9-oSAV8EnsC6OsXKLzSsmteyytg7PStyuccZw63-tgy2yU9o7Das0xAt0bFQX4XKfR-jjcfY-fS7mr08v04d5oUsqUqFoq4yi0JQ1b0ltdF0JJpiemIrpWhnaCsaZqUszaSpBarqYEGCq0fWiIcQINkLXu7l5xZ8BYpK9jRq6vCr4IUouCGuqqslgvQPziWIMYOQq2F6FtaREbmyRW1vk5v5ScLm1RfLcd7X_YGh7WBy69p6wf7fOjmg</recordid><startdate>199705</startdate><enddate>199705</enddate><creator>de Moraes, A A</creator><creator>Davidson, J A</creator><creator>Fleming, J G</creator><creator>Bazer, F W</creator><creator>Edwards, J L</creator><creator>Betts, J G</creator><creator>Hansen, P J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199705</creationdate><title>Lack of effect of granulocyte-macrophage colony-stimulating factor on secretion of interferon-tau, other proteins, and prostaglandin E2 by the bovine and ovine conceptus</title><author>de Moraes, A A ; Davidson, J A ; Fleming, J G ; Bazer, F W ; Edwards, J L ; Betts, J G ; Hansen, P J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c219t-a1bafa1e6257b05fc549393c8f43c5af1b9373f52f8649051d80e3a6c5d600f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Blastocyst - drug effects</topic><topic>Blastocyst - metabolism</topic><topic>Cattle</topic><topic>Culture Media, Conditioned</topic><topic>Dinoprostone - metabolism</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology</topic><topic>Insemination, Artificial</topic><topic>Interferon Type I</topic><topic>Interferon-gamma - metabolism</topic><topic>Organ Culture Techniques</topic><topic>Pregnancy Proteins - metabolism</topic><topic>Proteins - metabolism</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Moraes, A A</creatorcontrib><creatorcontrib>Davidson, J A</creatorcontrib><creatorcontrib>Fleming, J G</creatorcontrib><creatorcontrib>Bazer, F W</creatorcontrib><creatorcontrib>Edwards, J L</creatorcontrib><creatorcontrib>Betts, J G</creatorcontrib><creatorcontrib>Hansen, P J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Domestic animal endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Moraes, A A</au><au>Davidson, J A</au><au>Fleming, J G</au><au>Bazer, F W</au><au>Edwards, J L</au><au>Betts, J G</au><au>Hansen, P J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of effect of granulocyte-macrophage colony-stimulating factor on secretion of interferon-tau, other proteins, and prostaglandin E2 by the bovine and ovine conceptus</atitle><jtitle>Domestic animal endocrinology</jtitle><addtitle>Domest Anim Endocrinol</addtitle><date>1997-05</date><risdate>1997</risdate><volume>14</volume><issue>3</issue><spage>193</spage><epage>197</epage><pages>193-197</pages><issn>0739-7240</issn><abstract>Three experiments tested the effects of recombinant bovine granulocyte-macrophage colony-stimulating factor (rbGM-CSF) on the preimplantation bovine and ovine conceptus. 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| ispartof | Domestic animal endocrinology, 1997-05, Vol.14 (3), p.193-197 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Blastocyst - drug effects Blastocyst - metabolism Cattle Culture Media, Conditioned Dinoprostone - metabolism Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Insemination, Artificial Interferon Type I Interferon-gamma - metabolism Organ Culture Techniques Pregnancy Proteins - metabolism Proteins - metabolism Recombinant Proteins - pharmacology Swine |
| title | Lack of effect of granulocyte-macrophage colony-stimulating factor on secretion of interferon-tau, other proteins, and prostaglandin E2 by the bovine and ovine conceptus |
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