Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor

The specificity of target gene activation by steroid receptors is encoded within a small, cysteine-rich domain that is believed to form two zinc-coordinated fingers. Here we show that the ability of glucocorticoid and estrogen receptors to discriminate between their closely related response elements...

Ausführliche Beschreibung