The ER-Luminal Domain of the HCMV Glycoprotein US6 Inhibits Peptide Translocation by TAP

Human cytomegalovirus (HCMV) inhibits MHC class I antigen presentation by a sequential multistep process involving a family of unique short ( US) region–encoded glycoproteins. US3 retains class I molecules, whereas US2 and US11 mediate the cytosolic degradation of heavy chains by the proteosomes. In...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 1997-05, Vol.6 (5), p.613-621
Hauptverfasser:	Ahn, Kwangseog, Gruhler, Albrecht, Galocha, Begona, Jones, Thomas R, Wiertz, Emmanuel J.H.J, Ploegh, Hidde L, Peterson, Per A, Yang, Young, Früh, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence ATP-Binding Cassette Sub-Family B Member 2 ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - pharmacology Binding, Competitive Biological Transport - immunology Cytomegalovirus - chemistry Down-Regulation - immunology Endoplasmic Reticulum - chemistry Endoplasmic Reticulum - physiology Endoplasmic Reticulum - virology HeLa Cells Histocompatibility Antigens Class I - biosynthesis Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Humans Molecular Sequence Data Peptides - drug effects Peptides - metabolism Protein Binding - drug effects RNA-Binding Proteins - pharmacology Subcellular Fractions - metabolism Viral Envelope Proteins - chemistry Viral Envelope Proteins - metabolism Viral Envelope Proteins - pharmacology Viral Proteins - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!