Evaluation of an Open-Loop, Computer-Based Infusion System Designed to Achieve a Series of Constant, Targeted Plasma Procainamide Concentrations in Patients Undergoing Electrophysiologic Testing
Study Objective. To evaluate the performance of a computer‐based procainamide infusion system in patients undergoing electrophysiologic testing. Design. Prospective case series. Setting. Electrophysiology laboratory in a university hospital. Patients. Thirty‐four patients with inducible sustained ve...
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| Veröffentlicht in: | Pharmacotherapy 1997-05, Vol.17 (3), p.445-456 |
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| creator | Coyle, James D. Carnes, Cynthia A. Schaal, Stephen F. |
| description | Study Objective. To evaluate the performance of a computer‐based procainamide infusion system in patients undergoing electrophysiologic testing.
Design. Prospective case series.
Setting. Electrophysiology laboratory in a university hospital.
Patients. Thirty‐four patients with inducible sustained ventricular tachycardia.
Interventions. Intravenous infusion of procainamide to achieve and maintain targeted plasma concentrations.
Measurements and Main Results. System performance was assessed by comparing targeted and observed plasma concentrations. The population median absolute performance error (size of typical miss) was 12.6% (95% CI 11.2–14.1%). The population median performance error (system bias) was not significantly different from zero. A small but statistically significant improvement in performance over time was observed (population absolute performance error divergence −0.125%/min). Population wobble (overall system stability) was 7.6% (95% CI 6.8–8.3%). Population‐based estimates of central compartment volume and volume of distribution at steady state were significantly higher and lower, respectively, than estimates used by the infusion system.
Conclusion. The computer‐based infusion system is capable of achieving and maintaining a series of targeted procainamide concentrations in patients undergoing electrophysiologic testing. |
| doi_str_mv | 10.1002/j.1875-9114.1997.tb03055.x |
| format | Article |
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Design. Prospective case series.
Setting. Electrophysiology laboratory in a university hospital.
Patients. Thirty‐four patients with inducible sustained ventricular tachycardia.
Interventions. Intravenous infusion of procainamide to achieve and maintain targeted plasma concentrations.
Measurements and Main Results. System performance was assessed by comparing targeted and observed plasma concentrations. The population median absolute performance error (size of typical miss) was 12.6% (95% CI 11.2–14.1%). The population median performance error (system bias) was not significantly different from zero. A small but statistically significant improvement in performance over time was observed (population absolute performance error divergence −0.125%/min). Population wobble (overall system stability) was 7.6% (95% CI 6.8–8.3%). Population‐based estimates of central compartment volume and volume of distribution at steady state were significantly higher and lower, respectively, than estimates used by the infusion system.
Conclusion. The computer‐based infusion system is capable of achieving and maintaining a series of targeted procainamide concentrations in patients undergoing electrophysiologic testing.</description><identifier>ISSN: 0277-0008</identifier><identifier>EISSN: 1875-9114</identifier><identifier>DOI: 10.1002/j.1875-9114.1997.tb03055.x</identifier><identifier>PMID: 9165549</identifier><identifier>CODEN: PHPYDQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anti-Arrhythmia Agents - administration & dosage ; Anti-Arrhythmia Agents - blood ; Anti-Arrhythmia Agents - pharmacokinetics ; Anti-Arrhythmia Agents - therapeutic use ; Antiarythmic agents ; Biological and medical sciences ; Cardiovascular system ; Drug Therapy, Computer-Assisted ; Electrophysiology ; Female ; Humans ; Infusions, Intravenous - methods ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Procainamide - administration & dosage ; Procainamide - blood ; Procainamide - pharmacokinetics ; Procainamide - therapeutic use ; Retrospective Studies ; Tachycardia, Ventricular - drug therapy ; Tachycardia, Ventricular - metabolism</subject><ispartof>Pharmacotherapy, 1997-05, Vol.17 (3), p.445-456</ispartof><rights>1997 Pharmacotherapy Publications Inc.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3815-f614a0aebff319185dd7cf530118fc97e288cac3ad35c2f05a2208648e309b1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1875-9114.1997.tb03055.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1875-9114.1997.tb03055.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2690831$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9165549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coyle, James D.</creatorcontrib><creatorcontrib>Carnes, Cynthia A.</creatorcontrib><creatorcontrib>Schaal, Stephen F.</creatorcontrib><title>Evaluation of an Open-Loop, Computer-Based Infusion System Designed to Achieve a Series of Constant, Targeted Plasma Procainamide Concentrations in Patients Undergoing Electrophysiologic Testing</title><title>Pharmacotherapy</title><addtitle>Pharmacotherapy</addtitle><description>Study Objective. To evaluate the performance of a computer‐based procainamide infusion system in patients undergoing electrophysiologic testing.
Design. Prospective case series.
Setting. Electrophysiology laboratory in a university hospital.
Patients. Thirty‐four patients with inducible sustained ventricular tachycardia.
Interventions. Intravenous infusion of procainamide to achieve and maintain targeted plasma concentrations.
Measurements and Main Results. System performance was assessed by comparing targeted and observed plasma concentrations. The population median absolute performance error (size of typical miss) was 12.6% (95% CI 11.2–14.1%). The population median performance error (system bias) was not significantly different from zero. A small but statistically significant improvement in performance over time was observed (population absolute performance error divergence −0.125%/min). Population wobble (overall system stability) was 7.6% (95% CI 6.8–8.3%). Population‐based estimates of central compartment volume and volume of distribution at steady state were significantly higher and lower, respectively, than estimates used by the infusion system.
Conclusion. The computer‐based infusion system is capable of achieving and maintaining a series of targeted procainamide concentrations in patients undergoing electrophysiologic testing.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Arrhythmia Agents - administration & dosage</subject><subject>Anti-Arrhythmia Agents - blood</subject><subject>Anti-Arrhythmia Agents - pharmacokinetics</subject><subject>Anti-Arrhythmia Agents - therapeutic use</subject><subject>Antiarythmic agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Drug Therapy, Computer-Assisted</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Humans</subject><subject>Infusions, Intravenous - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Procainamide - administration & dosage</subject><subject>Procainamide - blood</subject><subject>Procainamide - pharmacokinetics</subject><subject>Procainamide - therapeutic use</subject><subject>Retrospective Studies</subject><subject>Tachycardia, Ventricular - drug therapy</subject><subject>Tachycardia, Ventricular - metabolism</subject><issn>0277-0008</issn><issn>1875-9114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkVFv0zAUhSMEGmPwE5AshHhaih0njcMTpXTdpMIq1gmJF-vWuelcEjvYyWj_Hr8Mh1Z958lXPt8590onit4wOmKUJu-3IybyLC4YS0esKPJRt6acZtlo9yQ6P0lPo3Oa5HlMKRXPoxfeb4OXjdPkLDor2DjL0uI8-jN7hLqHTltDbEXAkNsWTbywtr0kU9u0fYcu_gQeS3Jjqt4P4N3ed9iQz-j1xgShs2SiHjQ-IgFyh06jH8Km1vgOTHdJVuA22AVyWYNvgCydVaANNLrEAVNoOvfvCE-0Icswhh9P7k2JbmO12ZBZjapztn3YhxNqu9GKrNB3QXoZPaug9vjq-F5E91ez1fQ6XtzOb6aTRay4YFlcjVkKFHBdVZwVTGRlmasq45QxUakix0QIBYpDyTOVVDSDJKFinArktFgzxS-id4fc1tlffdgtG-0V1jUYtL2XeUF5wlIawA8HUDnrvcNKtk434PaSUTkUKLdyaEkOLcmhQHksUO6C-fVxS79usDxZj40F_e1RB6-grhwYpf0JS8YFFZwF7OMB-61r3P_HAXJ5Pfk2jCEiPkTo0PbuFAHupxznPLi_f51LcTX9Mf-SCbngfwHEY8un</recordid><startdate>199705</startdate><enddate>199705</enddate><creator>Coyle, James D.</creator><creator>Carnes, Cynthia A.</creator><creator>Schaal, Stephen F.</creator><general>Blackwell Publishing Ltd</general><general>Pharmacotherapy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199705</creationdate><title>Evaluation of an Open-Loop, Computer-Based Infusion System Designed to Achieve a Series of Constant, Targeted Plasma Procainamide Concentrations in Patients Undergoing Electrophysiologic Testing</title><author>Coyle, James D. ; Carnes, Cynthia A. ; Schaal, Stephen F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3815-f614a0aebff319185dd7cf530118fc97e288cac3ad35c2f05a2208648e309b1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Arrhythmia Agents - administration & dosage</topic><topic>Anti-Arrhythmia Agents - blood</topic><topic>Anti-Arrhythmia Agents - pharmacokinetics</topic><topic>Anti-Arrhythmia Agents - therapeutic use</topic><topic>Antiarythmic agents</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Drug Therapy, Computer-Assisted</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Humans</topic><topic>Infusions, Intravenous - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Procainamide - administration & dosage</topic><topic>Procainamide - blood</topic><topic>Procainamide - pharmacokinetics</topic><topic>Procainamide - therapeutic use</topic><topic>Retrospective Studies</topic><topic>Tachycardia, Ventricular - drug therapy</topic><topic>Tachycardia, Ventricular - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coyle, James D.</creatorcontrib><creatorcontrib>Carnes, Cynthia A.</creatorcontrib><creatorcontrib>Schaal, Stephen F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coyle, James D.</au><au>Carnes, Cynthia A.</au><au>Schaal, Stephen F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of an Open-Loop, Computer-Based Infusion System Designed to Achieve a Series of Constant, Targeted Plasma Procainamide Concentrations in Patients Undergoing Electrophysiologic Testing</atitle><jtitle>Pharmacotherapy</jtitle><addtitle>Pharmacotherapy</addtitle><date>1997-05</date><risdate>1997</risdate><volume>17</volume><issue>3</issue><spage>445</spage><epage>456</epage><pages>445-456</pages><issn>0277-0008</issn><eissn>1875-9114</eissn><coden>PHPYDQ</coden><abstract>Study Objective. To evaluate the performance of a computer‐based procainamide infusion system in patients undergoing electrophysiologic testing.
Design. Prospective case series.
Setting. Electrophysiology laboratory in a university hospital.
Patients. Thirty‐four patients with inducible sustained ventricular tachycardia.
Interventions. Intravenous infusion of procainamide to achieve and maintain targeted plasma concentrations.
Measurements and Main Results. System performance was assessed by comparing targeted and observed plasma concentrations. The population median absolute performance error (size of typical miss) was 12.6% (95% CI 11.2–14.1%). The population median performance error (system bias) was not significantly different from zero. A small but statistically significant improvement in performance over time was observed (population absolute performance error divergence −0.125%/min). Population wobble (overall system stability) was 7.6% (95% CI 6.8–8.3%). Population‐based estimates of central compartment volume and volume of distribution at steady state were significantly higher and lower, respectively, than estimates used by the infusion system.
Conclusion. The computer‐based infusion system is capable of achieving and maintaining a series of targeted procainamide concentrations in patients undergoing electrophysiologic testing.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9165549</pmid><doi>10.1002/j.1875-9114.1997.tb03055.x</doi><tpages>12</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Aged Aged, 80 and over Anti-Arrhythmia Agents - administration & dosage Anti-Arrhythmia Agents - blood Anti-Arrhythmia Agents - pharmacokinetics Anti-Arrhythmia Agents - therapeutic use Antiarythmic agents Biological and medical sciences Cardiovascular system Drug Therapy, Computer-Assisted Electrophysiology Female Humans Infusions, Intravenous - methods Male Medical sciences Middle Aged Pharmacology. Drug treatments Procainamide - administration & dosage Procainamide - blood Procainamide - pharmacokinetics Procainamide - therapeutic use Retrospective Studies Tachycardia, Ventricular - drug therapy Tachycardia, Ventricular - metabolism |
| title | Evaluation of an Open-Loop, Computer-Based Infusion System Designed to Achieve a Series of Constant, Targeted Plasma Procainamide Concentrations in Patients Undergoing Electrophysiologic Testing |
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