Oxidative N-demethylation of N, N-dimethylaniline by purified isozymes of cytochrome P-450

The metabolism of N, N-dimethylaniline (DMA) by rabbit liver microsomes results in the formation of N-methylaniline (NMA) and formaldehyde. The N-oxide of DMA (DMA N-oxide) has been suggested as an intermediate in the cytochrome P-450-catalyzed demethylation reaction. The role of DMA N-oxide as an i...

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Veröffentlicht in:	Biochemical pharmacology 1989-07, Vol.38 (13), p.2181-2185
Hauptverfasser:	Pandey, Ramendra N., Armstrong, Arthur P., Hollenberg, Paul F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - metabolism Animals Cytochrome P-450 Enzyme System - isolation & purification Cytochrome P-450 Enzyme System - metabolism Isoenzymes - isolation & purification Isoenzymes - metabolism Kinetics Microsomes, Liver - enzymology NADPH-Ferrihemoprotein Reductase - metabolism Rabbits
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