Role of ions and membrane potential in uptake of serotonin into plasma membrane vesicles from mouse brain

Plasma membrane vesicle preparations from mouse cerebral cortex actively accumulated [ 3H]serotonin upon the imposition of a K + gradient (in > out), a Na + gradient (out > in), and the presence of external Cl −. Maximal stimulation of uptake by internal K + occurred at 15 mM and half-maximal...

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Veröffentlicht in:	Biochemical pharmacology 1989-07, Vol.38 (13), p.2091-2097
Hauptverfasser:	Reith, Maarten E.A., Zimanyi, Ildiko, O'reilly, Cathy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences brain Cell Membrane - drug effects Cell Membrane - physiology Central nervous system Cerebral Cortex - metabolism Cerebral Cortex - physiology Chlorides - pharmacology Electrophysiology Female Fundamental and applied biological sciences. Psychology ions Kinetics Male membrane potential Membrane Potentials - drug effects membrane vesicles Mice Mice, Inbred BALB C Potassium - pharmacology Serotonin - metabolism Sodium - pharmacology Synaptosomes - drug effects Synaptosomes - physiology Valinomycin - pharmacology Vertebrates: nervous system and sense organs
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