Digoxin-like immunoreactive substance and sodium-potassium-adenosine triphosphatase inhibition in normal pregnancy: A longitudinal study
Objective: To measure the levels of digoxin-like immunoreactive substance and digitalis-like factor bioactivity as manifested by sodium-potassium-adenosine triphosphatase (ATPase) inhibition throughout pregnancy. Methods: Serum samples were collected from primigravidas in early (15 ± 1.8 weeks), mid...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1997-05, Vol.89 (5), p.743-746 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Gilson, George J. Graves, Steven W. Qualls, Clifford R. Curet, Luis B. |
| description | Objective: To measure the levels of digoxin-like immunoreactive substance and digitalis-like factor bioactivity as manifested by sodium-potassium-adenosine triphosphatase (ATPase) inhibition throughout pregnancy.
Methods: Serum samples were collected from primigravidas in early (15 ± 1.8 weeks), mid (26 ± 1.2 weeks), and late (36 ± 1.1 weeks) gestation, as well as at 6 ± 1.1 weeks postpartum (mean ± standard error). Digoxin-like immunoreactive substance levels were determined by radioimmunoassay and digitalis-like factor bioactivity was determined by inhibition of ATPase. Data were analyzed by means of repeated measures analysis of variance.
Results: In 41 women with normal pregnancy outcomes, levels of digoxin-like immunoreactive substance rose progressively and significantly (
P < .001) throughout pregnancy and returned to normal levels postpartum. Inhibition of ATPase activity also rose significantly (
P < .004), but not as dramatically, during pregnancy and remained elevated 6 weeks postpartum.
Conclusion: Although digoxin-like immunoreactive substance levels rise in pregnancy, functional digitalis-like factor activity, as manifested by inhibition of ATPase, does not parallel this rise strictly, implying that digoxin-like immunoreactive substance receptors may be reset during normal pregnancy. The enhanced cardiac performance that occurs in normal pregnancy may be mediated in part by increased digitalis-like factor activity. |
| doi_str_mv | 10.1016/S0029-7844(97)00090-2 |
| format | Article |
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Methods: Serum samples were collected from primigravidas in early (15 ± 1.8 weeks), mid (26 ± 1.2 weeks), and late (36 ± 1.1 weeks) gestation, as well as at 6 ± 1.1 weeks postpartum (mean ± standard error). Digoxin-like immunoreactive substance levels were determined by radioimmunoassay and digitalis-like factor bioactivity was determined by inhibition of ATPase. Data were analyzed by means of repeated measures analysis of variance.
Results: In 41 women with normal pregnancy outcomes, levels of digoxin-like immunoreactive substance rose progressively and significantly (
P < .001) throughout pregnancy and returned to normal levels postpartum. Inhibition of ATPase activity also rose significantly (
P < .004), but not as dramatically, during pregnancy and remained elevated 6 weeks postpartum.
Conclusion: Although digoxin-like immunoreactive substance levels rise in pregnancy, functional digitalis-like factor activity, as manifested by inhibition of ATPase, does not parallel this rise strictly, implying that digoxin-like immunoreactive substance receptors may be reset during normal pregnancy. The enhanced cardiac performance that occurs in normal pregnancy may be mediated in part by increased digitalis-like factor activity.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1016/S0029-7844(97)00090-2</identifier><identifier>PMID: 9166313</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenosine Triphosphatases - antagonists & inhibitors ; Adult ; Analysis of Variance ; Biological and medical sciences ; Biological Availability ; Cardenolides ; Digoxin ; Enzyme Inhibitors - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Hemodynamics - drug effects ; Hormone metabolism and regulation ; Humans ; Pregnancy - physiology ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Pregnancy Trimester, Third ; Pregnancy. Parturition. Lactation ; Prospective Studies ; Saponins - metabolism ; Vertebrates: reproduction</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1997-05, Vol.89 (5), p.743-746</ispartof><rights>1997 The American College of Obstetricians and Gynecologists</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4341-d90b0a51dbe4c71e6a3fb043a83bd61a9051aced513d2acffec04f0a054d397a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2651963$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9166313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gilson, George J.</creatorcontrib><creatorcontrib>Graves, Steven W.</creatorcontrib><creatorcontrib>Qualls, Clifford R.</creatorcontrib><creatorcontrib>Curet, Luis B.</creatorcontrib><title>Digoxin-like immunoreactive substance and sodium-potassium-adenosine triphosphatase inhibition in normal pregnancy: A longitudinal study</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Objective: To measure the levels of digoxin-like immunoreactive substance and digitalis-like factor bioactivity as manifested by sodium-potassium-adenosine triphosphatase (ATPase) inhibition throughout pregnancy.
Methods: Serum samples were collected from primigravidas in early (15 ± 1.8 weeks), mid (26 ± 1.2 weeks), and late (36 ± 1.1 weeks) gestation, as well as at 6 ± 1.1 weeks postpartum (mean ± standard error). Digoxin-like immunoreactive substance levels were determined by radioimmunoassay and digitalis-like factor bioactivity was determined by inhibition of ATPase. Data were analyzed by means of repeated measures analysis of variance.
Results: In 41 women with normal pregnancy outcomes, levels of digoxin-like immunoreactive substance rose progressively and significantly (
P < .001) throughout pregnancy and returned to normal levels postpartum. Inhibition of ATPase activity also rose significantly (
P < .004), but not as dramatically, during pregnancy and remained elevated 6 weeks postpartum.
Conclusion: Although digoxin-like immunoreactive substance levels rise in pregnancy, functional digitalis-like factor activity, as manifested by inhibition of ATPase, does not parallel this rise strictly, implying that digoxin-like immunoreactive substance receptors may be reset during normal pregnancy. The enhanced cardiac performance that occurs in normal pregnancy may be mediated in part by increased digitalis-like factor activity.</description><subject>Adenosine Triphosphatases - antagonists & inhibitors</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Cardenolides</subject><subject>Digoxin</subject><subject>Enzyme Inhibitors - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemodynamics - drug effects</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>Pregnancy - physiology</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy Trimester, Third</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Prospective Studies</subject><subject>Saponins - metabolism</subject><subject>Vertebrates: reproduction</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu1DAUtRCoDIVPqJQFQrAI2HEeYzaoKk-pEgtAYmfd2DcTU8cOttMyf8Bn43RGs2Vh-Vrnca1zCLlg9DWjrH3zjdJKlN22rl-K7hWlVNCyekA2bNvxsuL850OyOVEekycx_sok1gp-Rs4Ea1vO-Ib8fW92_o9xpTU3WJhpWpwPCCqZWyzi0scETmEBThfRa7NM5ewTxLhOoNH5aBwWKZh59HEeIWPZxo2mN8l4l8ciG05gizngzmWz_dvisrDe7UxatHEZiXnYPyWPBrARnx3vc_Lj44fvV5_L66-fvlxdXpeq5jUrtaA9hYbpHmvVMWyBDz2tOWx5r1sGgjYMFOqGcV2BGgZUtB4o0KbWXHTAz8mLg-8c_O8FY5KTiQqtBYd-ibITlOeQtpnYHIgq-BgDDnIOZoKwl4zKtQF534Bc45Wik_cNyCrrLo4Lln5CfVIdI8_48yMOUYEdQs7ExBOtahsm2pVWH2h33iYM8cYudxjkiGDTuC6jbdXQkgnR0Sa_ynwqlmXvDjLMGd6arIjKYK5Qm4AqSe3Nf_7_DwOitrs</recordid><startdate>199705</startdate><enddate>199705</enddate><creator>Gilson, George J.</creator><creator>Graves, Steven W.</creator><creator>Qualls, Clifford R.</creator><creator>Curet, Luis B.</creator><general>Elsevier Inc</general><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199705</creationdate><title>Digoxin-like immunoreactive substance and sodium-potassium-adenosine triphosphatase inhibition in normal pregnancy: A longitudinal study</title><author>Gilson, George J. ; Graves, Steven W. ; Qualls, Clifford R. ; Curet, Luis B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4341-d90b0a51dbe4c71e6a3fb043a83bd61a9051aced513d2acffec04f0a054d397a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adenosine Triphosphatases - antagonists & inhibitors</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Cardenolides</topic><topic>Digoxin</topic><topic>Enzyme Inhibitors - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemodynamics - drug effects</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>Pregnancy - physiology</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy Trimester, Third</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Prospective Studies</topic><topic>Saponins - metabolism</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gilson, George J.</creatorcontrib><creatorcontrib>Graves, Steven W.</creatorcontrib><creatorcontrib>Qualls, Clifford R.</creatorcontrib><creatorcontrib>Curet, Luis B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilson, George J.</au><au>Graves, Steven W.</au><au>Qualls, Clifford R.</au><au>Curet, Luis B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Digoxin-like immunoreactive substance and sodium-potassium-adenosine triphosphatase inhibition in normal pregnancy: A longitudinal study</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1997-05</date><risdate>1997</risdate><volume>89</volume><issue>5</issue><spage>743</spage><epage>746</epage><pages>743-746</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Objective: To measure the levels of digoxin-like immunoreactive substance and digitalis-like factor bioactivity as manifested by sodium-potassium-adenosine triphosphatase (ATPase) inhibition throughout pregnancy.
Methods: Serum samples were collected from primigravidas in early (15 ± 1.8 weeks), mid (26 ± 1.2 weeks), and late (36 ± 1.1 weeks) gestation, as well as at 6 ± 1.1 weeks postpartum (mean ± standard error). Digoxin-like immunoreactive substance levels were determined by radioimmunoassay and digitalis-like factor bioactivity was determined by inhibition of ATPase. Data were analyzed by means of repeated measures analysis of variance.
Results: In 41 women with normal pregnancy outcomes, levels of digoxin-like immunoreactive substance rose progressively and significantly (
P < .001) throughout pregnancy and returned to normal levels postpartum. Inhibition of ATPase activity also rose significantly (
P < .004), but not as dramatically, during pregnancy and remained elevated 6 weeks postpartum.
Conclusion: Although digoxin-like immunoreactive substance levels rise in pregnancy, functional digitalis-like factor activity, as manifested by inhibition of ATPase, does not parallel this rise strictly, implying that digoxin-like immunoreactive substance receptors may be reset during normal pregnancy. The enhanced cardiac performance that occurs in normal pregnancy may be mediated in part by increased digitalis-like factor activity.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9166313</pmid><doi>10.1016/S0029-7844(97)00090-2</doi><tpages>4</tpages></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 1997-05, Vol.89 (5), p.743-746 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenosine Triphosphatases - antagonists & inhibitors Adult Analysis of Variance Biological and medical sciences Biological Availability Cardenolides Digoxin Enzyme Inhibitors - metabolism Female Fundamental and applied biological sciences. Psychology Hemodynamics - drug effects Hormone metabolism and regulation Humans Pregnancy - physiology Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy Trimester, Third Pregnancy. Parturition. Lactation Prospective Studies Saponins - metabolism Vertebrates: reproduction |
| title | Digoxin-like immunoreactive substance and sodium-potassium-adenosine triphosphatase inhibition in normal pregnancy: A longitudinal study |
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