Geometric Control of Cell Life and Death

Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension. Cell spreading also was varied while maintaining the total c...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1997-05, Vol.276 (5317), p.1425-1428
Hauptverfasser:	Chen, Christopher S., Mrksich, Milan, Huang, Sui, Whitesides, George M., Ingber, Donald E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesives Animals Antibodies Apoptosis Apoptosis - physiology B lymphocytes Biological and medical sciences Cattle Cell adhesion Cell Adhesion - physiology Cell death Cell Division - physiology Cell growth Cell interaction Cell interactions Cell interactions, adhesion Cell nucleus Cell Size - physiology Cells Cells (Biology) Cells, Cultured Cellular biology Cultured cells Endothelial cells Endothelium, Vascular - cytology Endothelium, Vascular - physiology Extracellular Matrix - physiology Fibronectins - physiology Fundamental and applied biological sciences. Psychology Geometric Concepts Humans Integrin beta1 - physiology Integrins Integrins - physiology Ligands Molecular and cellular biology Morphology Morphology (Biology) Physiological aspects Space life sciences Vitronectin - physiology
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