Interleukin-12 induced cytolytic activity in lymphocytes from recipients of autologous and allogeneic stem cell transplants

Interleukin-12 (IL-12) has been reported to enhance the cytolytic activity of NK and activated T cells and to induce low levels of lymphokine-activated killer (LAK) activity in normal human lymphocytes. Therapy with IL-12 has induced tumor eradication in murine models. These observations suggest tha...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 1997-05, Vol.19 (9), p.867-873
Hauptverfasser:	LINDGREN, C. G, THOMPSON, J. A, ROBINSON, N, KEELER, T, GOLD, P. J, FEFER, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Antineoplastic agents Autografts Biological and medical sciences Bone marrow Bone marrow transplantation Cells, Cultured Chromium radioisotopes Cytokines Cytolytic activity Cytotoxicity Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Immunotherapy Interleukin 12 Interleukin 2 Interleukin-12 - metabolism Interleukin-12 - pharmacology Interleukins Killer Cells, Lymphokine-Activated - drug effects Leukocytes, Mononuclear - drug effects Lymphocytes Lymphocytes T Lysis Medical sciences Minimal residual disease Patients Peripheral blood Pharmacology. Drug treatments Receptors, Interleukin - metabolism Receptors, Interleukin-12 Stem cell transplantation Stem cells Toxicity Transplantation Transplantation, Autologous Transplantation, Homologous Transplants Tumors
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