High prevalence of hepatitis G virus in bone marrow transplant recipients and patients treated for acute leukemia
Hepatitis G virus (HGV) is a newly described virus that has been implicated in transfusion-associated hepatitis. The prevalence of HGV in a group of multitransfused patients with hematological malignancy was studied using a reverse transcription polymerase chain reaction technique. Transfusion histo...
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| Veröffentlicht in: | Blood 1997-05, Vol.89 (10), p.3853-3856 |
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| creator | SKIDMORE, S. J COLLINGHAM, K. E HARRISON, P NEILSON, J. R PILLAY, D MILLIGAN, D. W |
| description | Hepatitis G virus (HGV) is a newly described virus that has been implicated in transfusion-associated hepatitis. The prevalence of HGV in a group of multitransfused patients with hematological malignancy was studied using a reverse transcription polymerase chain reaction technique. Transfusion histories and serum aspartate aminotransferase (AST) levels were recorded. HGV was detected in 29 of 60 (48%) patients. There was no difference in HGV positivity rates between those with normal AST levels and those with raised AST levels. Analysis of patients by treatment type showed that 20 of 33 (61%) patients who received a bone marrow transplantation procedure were HGV positive compared with 9 of 27 (33%) treated with conventional combination chemotherapy (P = .036) despite similar transfusion histories. There was no significant difference in HGV positivity between patients treated before the introduction of United Kingdom blood donor screening for hepatitis C virus antibody:18 of 39 (46%) and those treated after the introduction of screening 11 of 21 (52%). HGV infection appears to be extremely common in these patients; however, the clinical significance of these findings with respect to liver dysfunction is not yet clear. |
| doi_str_mv | 10.1182/blood.v89.10.3853 |
| format | Article |
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J ; COLLINGHAM, K. E ; HARRISON, P ; NEILSON, J. R ; PILLAY, D ; MILLIGAN, D. W</creator><creatorcontrib>SKIDMORE, S. J ; COLLINGHAM, K. E ; HARRISON, P ; NEILSON, J. R ; PILLAY, D ; MILLIGAN, D. W</creatorcontrib><description>Hepatitis G virus (HGV) is a newly described virus that has been implicated in transfusion-associated hepatitis. The prevalence of HGV in a group of multitransfused patients with hematological malignancy was studied using a reverse transcription polymerase chain reaction technique. Transfusion histories and serum aspartate aminotransferase (AST) levels were recorded. HGV was detected in 29 of 60 (48%) patients. There was no difference in HGV positivity rates between those with normal AST levels and those with raised AST levels. Analysis of patients by treatment type showed that 20 of 33 (61%) patients who received a bone marrow transplantation procedure were HGV positive compared with 9 of 27 (33%) treated with conventional combination chemotherapy (P = .036) despite similar transfusion histories. There was no significant difference in HGV positivity between patients treated before the introduction of United Kingdom blood donor screening for hepatitis C virus antibody:18 of 39 (46%) and those treated after the introduction of screening 11 of 21 (52%). HGV infection appears to be extremely common in these patients; however, the clinical significance of these findings with respect to liver dysfunction is not yet clear.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.v89.10.3853</identifier><identifier>PMID: 9160693</identifier><language>eng</language><publisher>Washington, DC: The Americain Society of Hematology</publisher><subject>Acute Disease ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Aspartate Aminotransferases - blood ; Biological and medical sciences ; Biomarkers ; Blood Donors ; Blood Transfusion - standards ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Bone Marrow Transplantation - adverse effects ; Flaviviridae - isolation & purification ; Hematologic Neoplasms - complications ; Hematologic Neoplasms - therapy ; Hematologic Neoplasms - virology ; Hepatitis C - blood ; Hepatitis C - diagnosis ; Hepatitis C - prevention & control ; Hepatitis, Viral, Human - complications ; Hepatitis, Viral, Human - epidemiology ; Hepatitis, Viral, Human - transmission ; Humans ; Leukemia - complications ; Leukemia - therapy ; Leukemia - virology ; Mass Screening ; Medical sciences ; Prevalence ; Retrospective Studies ; RNA, Viral - blood ; RNA, Viral - isolation & purification ; Tissue Donors ; Transfusion Reaction ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; United Kingdom - epidemiology</subject><ispartof>Blood, 1997-05, Vol.89 (10), p.3853-3856</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2833-7a61a3cba6fadff58eb4cc729b6c5e82905762b70af774b4cabe822c3b81bc073</citedby><cites>FETCH-LOGICAL-c2833-7a61a3cba6fadff58eb4cc729b6c5e82905762b70af774b4cabe822c3b81bc073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2673464$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9160693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SKIDMORE, S. J</creatorcontrib><creatorcontrib>COLLINGHAM, K. E</creatorcontrib><creatorcontrib>HARRISON, P</creatorcontrib><creatorcontrib>NEILSON, J. R</creatorcontrib><creatorcontrib>PILLAY, D</creatorcontrib><creatorcontrib>MILLIGAN, D. W</creatorcontrib><title>High prevalence of hepatitis G virus in bone marrow transplant recipients and patients treated for acute leukemia</title><title>Blood</title><addtitle>Blood</addtitle><description>Hepatitis G virus (HGV) is a newly described virus that has been implicated in transfusion-associated hepatitis. The prevalence of HGV in a group of multitransfused patients with hematological malignancy was studied using a reverse transcription polymerase chain reaction technique. Transfusion histories and serum aspartate aminotransferase (AST) levels were recorded. HGV was detected in 29 of 60 (48%) patients. There was no difference in HGV positivity rates between those with normal AST levels and those with raised AST levels. Analysis of patients by treatment type showed that 20 of 33 (61%) patients who received a bone marrow transplantation procedure were HGV positive compared with 9 of 27 (33%) treated with conventional combination chemotherapy (P = .036) despite similar transfusion histories. There was no significant difference in HGV positivity between patients treated before the introduction of United Kingdom blood donor screening for hepatitis C virus antibody:18 of 39 (46%) and those treated after the introduction of screening 11 of 21 (52%). HGV infection appears to be extremely common in these patients; however, the clinical significance of these findings with respect to liver dysfunction is not yet clear.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Blood Donors</subject><subject>Blood Transfusion - standards</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Bone Marrow Transplantation - adverse effects</subject><subject>Flaviviridae - isolation & purification</subject><subject>Hematologic Neoplasms - complications</subject><subject>Hematologic Neoplasms - therapy</subject><subject>Hematologic Neoplasms - virology</subject><subject>Hepatitis C - blood</subject><subject>Hepatitis C - diagnosis</subject><subject>Hepatitis C - prevention & control</subject><subject>Hepatitis, Viral, Human - complications</subject><subject>Hepatitis, Viral, Human - epidemiology</subject><subject>Hepatitis, Viral, Human - transmission</subject><subject>Humans</subject><subject>Leukemia - complications</subject><subject>Leukemia - therapy</subject><subject>Leukemia - virology</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>RNA, Viral - blood</subject><subject>RNA, Viral - isolation & purification</subject><subject>Tissue Donors</subject><subject>Transfusion Reaction</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>United Kingdom - epidemiology</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1v1DAQhi1UVJbCD-BQyYeKWxZ_JLZzRFW7RarEBbhGY2dMTbNxajuL-Pd421VPo3k_RvZDyCfOtpwb8cVOMY7bg-m3VZGmk2_IhnfCNIwJdkY2jDHVtL3m78j7nP8wxlspunNy3nPFVC835Oku_H6gS8IDTDg7pNHTB1yghBIy3dFDSGumYaY2zkj3kFL8S0uCOS8TzIUmdGEJOJdMYR7psfi8lIRQcKQ-JgpuLUgnXB9xH-ADeethyvjxNC_Iz9ubH9d3zf333bfrr_eNE0bKRoPiIJ0F5WH0vjNoW-e06K1yHRrRs04rYTUDr3VbPbBVFU5aw61jWl6Qzy93lxSfVsxl2IfscKrPxrjmQfdMqI6pGuQvQZdizgn9sKRQf_pv4Gw4Yh6eMQ-_TH9Ujphr5_J0fLV7HF8bJ67Vvzr5kB1MvgJzIb_GhNKyVa38D7UHiUg</recordid><startdate>19970515</startdate><enddate>19970515</enddate><creator>SKIDMORE, S. J</creator><creator>COLLINGHAM, K. E</creator><creator>HARRISON, P</creator><creator>NEILSON, J. 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Cell therapy and gene therapy</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Blood Donors</topic><topic>Blood Transfusion - standards</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Bone Marrow Transplantation - adverse effects</topic><topic>Flaviviridae - isolation & purification</topic><topic>Hematologic Neoplasms - complications</topic><topic>Hematologic Neoplasms - therapy</topic><topic>Hematologic Neoplasms - virology</topic><topic>Hepatitis C - blood</topic><topic>Hepatitis C - diagnosis</topic><topic>Hepatitis C - prevention & control</topic><topic>Hepatitis, Viral, Human - complications</topic><topic>Hepatitis, Viral, Human - epidemiology</topic><topic>Hepatitis, Viral, Human - transmission</topic><topic>Humans</topic><topic>Leukemia - complications</topic><topic>Leukemia - therapy</topic><topic>Leukemia - virology</topic><topic>Mass Screening</topic><topic>Medical sciences</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>RNA, Viral - blood</topic><topic>RNA, Viral - isolation & purification</topic><topic>Tissue Donors</topic><topic>Transfusion Reaction</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SKIDMORE, S. J</creatorcontrib><creatorcontrib>COLLINGHAM, K. E</creatorcontrib><creatorcontrib>HARRISON, P</creatorcontrib><creatorcontrib>NEILSON, J. R</creatorcontrib><creatorcontrib>PILLAY, D</creatorcontrib><creatorcontrib>MILLIGAN, D. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SKIDMORE, S. J</au><au>COLLINGHAM, K. E</au><au>HARRISON, P</au><au>NEILSON, J. R</au><au>PILLAY, D</au><au>MILLIGAN, D. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of hepatitis G virus in bone marrow transplant recipients and patients treated for acute leukemia</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1997-05-15</date><risdate>1997</risdate><volume>89</volume><issue>10</issue><spage>3853</spage><epage>3856</epage><pages>3853-3856</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Hepatitis G virus (HGV) is a newly described virus that has been implicated in transfusion-associated hepatitis. The prevalence of HGV in a group of multitransfused patients with hematological malignancy was studied using a reverse transcription polymerase chain reaction technique. Transfusion histories and serum aspartate aminotransferase (AST) levels were recorded. HGV was detected in 29 of 60 (48%) patients. There was no difference in HGV positivity rates between those with normal AST levels and those with raised AST levels. Analysis of patients by treatment type showed that 20 of 33 (61%) patients who received a bone marrow transplantation procedure were HGV positive compared with 9 of 27 (33%) treated with conventional combination chemotherapy (P = .036) despite similar transfusion histories. There was no significant difference in HGV positivity between patients treated before the introduction of United Kingdom blood donor screening for hepatitis C virus antibody:18 of 39 (46%) and those treated after the introduction of screening 11 of 21 (52%). HGV infection appears to be extremely common in these patients; however, the clinical significance of these findings with respect to liver dysfunction is not yet clear.</abstract><cop>Washington, DC</cop><pub>The Americain Society of Hematology</pub><pmid>9160693</pmid><doi>10.1182/blood.v89.10.3853</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aspartate Aminotransferases - blood Biological and medical sciences Biomarkers Blood Donors Blood Transfusion - standards Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone Marrow Transplantation - adverse effects Flaviviridae - isolation & purification Hematologic Neoplasms - complications Hematologic Neoplasms - therapy Hematologic Neoplasms - virology Hepatitis C - blood Hepatitis C - diagnosis Hepatitis C - prevention & control Hepatitis, Viral, Human - complications Hepatitis, Viral, Human - epidemiology Hepatitis, Viral, Human - transmission Humans Leukemia - complications Leukemia - therapy Leukemia - virology Mass Screening Medical sciences Prevalence Retrospective Studies RNA, Viral - blood RNA, Viral - isolation & purification Tissue Donors Transfusion Reaction Transfusions. Complications. Transfusion reactions. Cell and gene therapy United Kingdom - epidemiology |
| title | High prevalence of hepatitis G virus in bone marrow transplant recipients and patients treated for acute leukemia |
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