Select Alterations in Protein Kinases and Phosphatases During Apoptosis of Differentiated PC12 Cells

: The involvement of cell cycle‐regulatory proteins in apoptosis of neuronally differentiated PC12 cells induced by the removal of nerve growth factor and serum was examined. Three major findings are presented. (1) Cdc2 kinase protein levels increased fivefold in apoptotic PC12 cells by day 3 of ser...

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Veröffentlicht in:	Journal of neurochemistry 1997-06, Vol.68 (6), p.2338-2347
Hauptverfasser:	Davis, Penny K., Dudek, Serena M., Johnson, Gail V. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Biological and medical sciences Calcineurin Calmodulin-Binding Proteins - metabolism Cdc2 kinase CDC2 Protein Kinase - metabolism Cell Cycle Proteins - metabolism Cell Differentiation - physiology Fundamental and applied biological sciences. Psychology Fungal Proteins - isolation & purification Fungal Proteins - metabolism Immunoblotting Isolated neuron and nerve. Neuroglia Maturation-Promoting Factor - metabolism Nerve growth factor Nerve Growth Factors - pharmacology PC12 Cells - cytology PC12 Cells - drug effects PC12 Cells - enzymology Phosphoprotein Phosphatases - metabolism Precipitin Tests Programmed cell death Protein Kinases - metabolism Protein Phosphatase 1 Protein Phosphatase 2 Rats Schizosaccharomyces pombe Proteins Serine/threonine phosphatases Vertebrates: nervous system and sense organs
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