Neuropeptide Y Receptor Genes on Human Chromosome 4q31–q32 Map to Conserved Linkage Groups on Mouse Chromosomes 3 and 8
Npy1randNpy2r,the genes encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. Previous studies have localized the human genes encoding these receptors to chromosome 4q31–q32. We have now assignedNpy1randNpy2rto conserved linkage groups on mo...
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| Veröffentlicht in: | Genomics 1997-05, Vol.41 (3), p.498-500 |
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| creator | Lutz, C.M. Frankel, W.N. Richards, J.E. Thompson, D.A. |
| description | Npy1randNpy2r,the genes encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. Previous studies have localized the human genes encoding these receptors to chromosome 4q31–q32. We have now assignedNpy1randNpy2rto conserved linkage groups on mouse Chr 8 and Chr 3, respectively, which correspond to the distal region of human chromosome 4q. Using yeast artificial chromosomes, we have estimated the distance between the human genes to be approximately 6 cM. Although ancient tandem duplication events may account for some closely spaced G-protein-coupled receptor genes, the large genetic distance between the human type 1 and type 2 neuropeptide Y receptor genes raises questions about whether this mechanism accounts for their proximity. |
| doi_str_mv | 10.1006/geno.1997.4698 |
| format | Article |
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Previous studies have localized the human genes encoding these receptors to chromosome 4q31–q32. We have now assignedNpy1randNpy2rto conserved linkage groups on mouse Chr 8 and Chr 3, respectively, which correspond to the distal region of human chromosome 4q. Using yeast artificial chromosomes, we have estimated the distance between the human genes to be approximately 6 cM. Although ancient tandem duplication events may account for some closely spaced G-protein-coupled receptor genes, the large genetic distance between the human type 1 and type 2 neuropeptide Y receptor genes raises questions about whether this mechanism accounts for their proximity.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1997.4698</identifier><identifier>PMID: 9169155</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>AMINO ACID SEQUENCE ; Animals ; Base Sequence ; Biological and medical sciences ; BIOLOGICAL EVOLUTION ; BIOLOGICAL MARKERS ; BIOLOGY AND MEDICINE, BASIC STUDIES ; Chromosome Mapping ; Chromosomes, Artificial, Yeast ; Chromosomes, Human, Pair 4 - genetics ; Classical genetics, quantitative genetics, hybrids ; Conserved Sequence ; CONTIGS ; Crosses, Genetic ; DNA - genetics ; DNA HYBRIDIZATION ; DNA SEQUENCING ; DNA-CLONING ; Evolution, Molecular ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Linkage ; GENETIC MAPPING ; Genetics of eukaryotes. Biological and molecular evolution ; GTP-ASES ; HUMAN CHROMOSOMES ; Humans ; Male ; MICE ; Mice, Inbred C57BL ; Muridae ; PEPTIDES ; POLYMERASE CHAIN REACTION ; RECEPTORS ; Receptors, Neuropeptide Y - genetics ; RFLPS ; Species Specificity ; TRANSCRIPTION ; Vertebrata</subject><ispartof>Genomics, 1997-05, Vol.41 (3), p.498-500</ispartof><rights>1997 Academic Press</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-fe54f429a623493667f3bef7f6c2ba17ac9b0ad3ecaf519d7df7f889d5141b413</citedby><cites>FETCH-LOGICAL-c394t-fe54f429a623493667f3bef7f6c2ba17ac9b0ad3ecaf519d7df7f889d5141b413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S088875439794698X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2661100$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9169155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/530753$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Lutz, C.M.</creatorcontrib><creatorcontrib>Frankel, W.N.</creatorcontrib><creatorcontrib>Richards, J.E.</creatorcontrib><creatorcontrib>Thompson, D.A.</creatorcontrib><title>Neuropeptide Y Receptor Genes on Human Chromosome 4q31–q32 Map to Conserved Linkage Groups on Mouse Chromosomes 3 and 8</title><title>Genomics</title><addtitle>Genomics</addtitle><description>Npy1randNpy2r,the genes encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. Previous studies have localized the human genes encoding these receptors to chromosome 4q31–q32. We have now assignedNpy1randNpy2rto conserved linkage groups on mouse Chr 8 and Chr 3, respectively, which correspond to the distal region of human chromosome 4q. Using yeast artificial chromosomes, we have estimated the distance between the human genes to be approximately 6 cM. Although ancient tandem duplication events may account for some closely spaced G-protein-coupled receptor genes, the large genetic distance between the human type 1 and type 2 neuropeptide Y receptor genes raises questions about whether this mechanism accounts for their proximity.</description><subject>AMINO ACID SEQUENCE</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EVOLUTION</subject><subject>BIOLOGICAL MARKERS</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Artificial, Yeast</subject><subject>Chromosomes, Human, Pair 4 - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Conserved Sequence</subject><subject>CONTIGS</subject><subject>Crosses, Genetic</subject><subject>DNA - genetics</subject><subject>DNA HYBRIDIZATION</subject><subject>DNA SEQUENCING</subject><subject>DNA-CLONING</subject><subject>Evolution, Molecular</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Linkage</subject><subject>GENETIC MAPPING</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>GTP-ASES</subject><subject>HUMAN CHROMOSOMES</subject><subject>Humans</subject><subject>Male</subject><subject>MICE</subject><subject>Mice, Inbred C57BL</subject><subject>Muridae</subject><subject>PEPTIDES</subject><subject>POLYMERASE CHAIN REACTION</subject><subject>RECEPTORS</subject><subject>Receptors, Neuropeptide Y - genetics</subject><subject>RFLPS</subject><subject>Species Specificity</subject><subject>TRANSCRIPTION</subject><subject>Vertebrata</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcGKFDEURYMoYzu6dSdEEHfVJpVUKllKoz0DPQqiC1chlbyaiXYl1UnVwOz8B__QL5mU3QxuXCVwz7289y5CLylZU0LEu2sIcU2VatdcKPkIrSiRqpKCi8doRaSUVdtw9hQ9y_kHIUQxWZ-hM0WFok2zQnefYE5xhHHyDvB3_AVs-ceEtxAg4xjwxTyYgDc3KQ4xxwEwPzD659fvA6vxlRnxFPEmhgzpFhze-fDTXAPepjiPf-1Xcc7wjz1jhk1wWD5HT3qzz_Di9J6jbx8_fN1cVLvP28vN-11lmeJT1UPDe14rI2rGFROi7VkHfdsLW3eGtsaqjhjHwJq-ocq1rmhSKtdQTjtO2Tl6fcyNefI6Wz-BvbExBLCTbhhpG1aYt0dmTPEwQ5704LOF_d4EKPPrVpGaUVkXcH0EbYo5J-j1mPxg0p2mRC996KUPvfShlz6K4dUpee4GcA_4qYCivznpJluz75MJ1ucHrBaCltiCySMG5VK3HtKyCAQLzqdlDxf9_ya4B6VGpus</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Lutz, C.M.</creator><creator>Frankel, W.N.</creator><creator>Richards, J.E.</creator><creator>Thompson, D.A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19970501</creationdate><title>Neuropeptide Y Receptor Genes on Human Chromosome 4q31–q32 Map to Conserved Linkage Groups on Mouse Chromosomes 3 and 8</title><author>Lutz, C.M. ; Frankel, W.N. ; Richards, J.E. ; Thompson, D.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-fe54f429a623493667f3bef7f6c2ba17ac9b0ad3ecaf519d7df7f889d5141b413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>AMINO ACID SEQUENCE</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EVOLUTION</topic><topic>BIOLOGICAL MARKERS</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Artificial, Yeast</topic><topic>Chromosomes, Human, Pair 4 - genetics</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Conserved Sequence</topic><topic>CONTIGS</topic><topic>Crosses, Genetic</topic><topic>DNA - genetics</topic><topic>DNA HYBRIDIZATION</topic><topic>DNA SEQUENCING</topic><topic>DNA-CLONING</topic><topic>Evolution, Molecular</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Linkage</topic><topic>GENETIC MAPPING</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>GTP-ASES</topic><topic>HUMAN CHROMOSOMES</topic><topic>Humans</topic><topic>Male</topic><topic>MICE</topic><topic>Mice, Inbred C57BL</topic><topic>Muridae</topic><topic>PEPTIDES</topic><topic>POLYMERASE CHAIN REACTION</topic><topic>RECEPTORS</topic><topic>Receptors, Neuropeptide Y - genetics</topic><topic>RFLPS</topic><topic>Species Specificity</topic><topic>TRANSCRIPTION</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lutz, C.M.</creatorcontrib><creatorcontrib>Frankel, W.N.</creatorcontrib><creatorcontrib>Richards, J.E.</creatorcontrib><creatorcontrib>Thompson, D.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lutz, C.M.</au><au>Frankel, W.N.</au><au>Richards, J.E.</au><au>Thompson, D.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropeptide Y Receptor Genes on Human Chromosome 4q31–q32 Map to Conserved Linkage Groups on Mouse Chromosomes 3 and 8</atitle><jtitle>Genomics</jtitle><addtitle>Genomics</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>41</volume><issue>3</issue><spage>498</spage><epage>500</epage><pages>498-500</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>Npy1randNpy2r,the genes encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. Previous studies have localized the human genes encoding these receptors to chromosome 4q31–q32. We have now assignedNpy1randNpy2rto conserved linkage groups on mouse Chr 8 and Chr 3, respectively, which correspond to the distal region of human chromosome 4q. Using yeast artificial chromosomes, we have estimated the distance between the human genes to be approximately 6 cM. Although ancient tandem duplication events may account for some closely spaced G-protein-coupled receptor genes, the large genetic distance between the human type 1 and type 2 neuropeptide Y receptor genes raises questions about whether this mechanism accounts for their proximity.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>9169155</pmid><doi>10.1006/geno.1997.4698</doi><tpages>3</tpages></addata></record> |
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| subjects | AMINO ACID SEQUENCE Animals Base Sequence Biological and medical sciences BIOLOGICAL EVOLUTION BIOLOGICAL MARKERS BIOLOGY AND MEDICINE, BASIC STUDIES Chromosome Mapping Chromosomes, Artificial, Yeast Chromosomes, Human, Pair 4 - genetics Classical genetics, quantitative genetics, hybrids Conserved Sequence CONTIGS Crosses, Genetic DNA - genetics DNA HYBRIDIZATION DNA SEQUENCING DNA-CLONING Evolution, Molecular Female Fundamental and applied biological sciences. Psychology Genetic Linkage GENETIC MAPPING Genetics of eukaryotes. Biological and molecular evolution GTP-ASES HUMAN CHROMOSOMES Humans Male MICE Mice, Inbred C57BL Muridae PEPTIDES POLYMERASE CHAIN REACTION RECEPTORS Receptors, Neuropeptide Y - genetics RFLPS Species Specificity TRANSCRIPTION Vertebrata |
| title | Neuropeptide Y Receptor Genes on Human Chromosome 4q31–q32 Map to Conserved Linkage Groups on Mouse Chromosomes 3 and 8 |
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