Control of Ca2+ channel current and exocytosis in rat lactotrophs by basally active protein kinase C and calcineurin

Modulation of voltage-activated Ca2+ channel activity by phosphorylation was studied in metabolically intact voltage-clamped rat lactotrophs. Experiments using Ba2+ as a charge carrier indicated that a phorbol ester protein kinase C activator stimulates high-voltage-activated Ca2+ channel currents,...

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Veröffentlicht in:	Neuroscience 1997-05, Vol.78 (2), p.523-531
Hauptverfasser:	FOMINA, A. F, LEVITAN, E. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Barium - metabolism Biological and medical sciences Calcineurin Calcium Channels - drug effects Calcium Channels - physiology Calmodulin-Binding Proteins - antagonists & inhibitors Calmodulin-Binding Proteins - metabolism Calmodulin-Binding Proteins - physiology Cells, Cultured Electric Stimulation Enzyme Activation - physiology Enzyme Inhibitors - pharmacology Exocytosis - drug effects Exocytosis - physiology Female Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Ion Channel Gating - drug effects Ion Channel Gating - physiology Membrane Potentials - physiology Patch-Clamp Techniques Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - metabolism Phosphoprotein Phosphatases - physiology Pituitary Gland, Anterior - cytology Pituitary Gland, Anterior - enzymology Pituitary Gland, Anterior - physiology Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein Kinase C - physiology Rats Rats, Sprague-Dawley Vertebrates: endocrinology
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