Expression and function of amphiregulin during murine preimplantation development

Amphiregulin (Ar) is an EGF receptor ligand that functions to modulate the growth of both normal and malignant epithelial cells. We asked whether mouse preimplantation embryos express Ar, and if so, what the function of Ar is during preimplantation development. We used RT‐PCR to show expression of A...

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Veröffentlicht in:	Molecular reproduction and development 1997-07, Vol.47 (3), p.271-283
Hauptverfasser:	Tsark, Eleanor C., Adamson, Eileen D., Withers III, George E., Wiley, Lynn M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphiregulin Animals autocrine Biological and medical sciences Blastocyst - drug effects Blastocyst - metabolism Cell Differentiation Cell Division Culture Techniques DNA, Complementary - metabolism EGF Family of Proteins Embryology: invertebrates and vertebrates. Teratology Female Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology Glycoproteins - genetics Glycoproteins - physiology Growth Substances - genetics Growth Substances - physiology Intercellular Signaling Peptides and Proteins Mice Molecular embryology Oligonucleotides, Antisense - pharmacology Polymerase Chain Reaction preimplantation embryo Recombinant Proteins - metabolism Restriction Mapping RT-PCR TGF-α Thionucleotides - pharmacology Transforming Growth Factor alpha - pharmacology Trophoblasts - cytology
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