Mdm2 promotes the rapid degradation of p53

The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest and apoptosis, in response to various types of stress 1 . The activity of p53 is abrogated by mutations that occur frequently in tumours, as well as by several viral and cellular proteins 1,2 . The Mdm2 oncop...

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Veröffentlicht in:	Nature (London) 1997-05, Vol.387 (6630), p.296-299
Hauptverfasser:	Haupt, Ygal, Maya, Ruth, Kazaz, Anat, Oren, Moshe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell cycle, cell proliferation Cell physiology Down-Regulation - radiation effects Fundamental and applied biological sciences. Psychology Genetics HeLa Cells Humanities and Social Sciences Humans letter Mice Molecular and cellular biology multidisciplinary Nuclear Proteins Protein Binding Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism RNA, Messenger - metabolism Science Science (multidisciplinary) Transfection Tumor Cells, Cultured Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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