Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation
We studied the effects of low-frequency transcranial magnetic stimulation (TMS) on motor cortex excitability in humans. TMS at 0.1 Hz for 1 hour did not change cortical excitability. Stimulation at 0.9 Hz for 15 minutes (810 pulses), similar to the parameters used to induce long-term depression (LTD...
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| Veröffentlicht in: | Neurology 1997-05, Vol.48 (5), p.1398-1403 |
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| container_title | Neurology |
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| creator | CHEN, R CLASSEN, J GERLOFF, C CELNIK, P WASSERMANN, E. M HALLETT, M COHEN, L. G |
| description | We studied the effects of low-frequency transcranial magnetic stimulation (TMS) on motor cortex excitability in humans. TMS at 0.1 Hz for 1 hour did not change cortical excitability. Stimulation at 0.9 Hz for 15 minutes (810 pulses), similar to the parameters used to induce long-term depression (LTD) in cortical slice preparations and in vivo animal studies, led to a mean decrease in motor evoked potential (MEP) amplitude of 19.5%. The decrease in cortical excitability lasted for at least 15 minutes after the end of the 0.9 Hz stimulation. The mechanism underlying this decrease in excitability may be similar to LTD. TMS-induced reduction of cortical excitability has potential clinical applications in diseases such as epilepsy and myoclonus. Spread of excitation, which may be a warning sign for seizures, occurred in one subject and was not accompanied by increased MEP amplitude, suggesting that spread of excitation and amplitude changes are different phenomena and also indicating the need for adequate monitoring even with stimulations at low frequencies. |
| doi_str_mv | 10.1212/wnl.48.5.1398 |
| format | Article |
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TMS-induced reduction of cortical excitability has potential clinical applications in diseases such as epilepsy and myoclonus. Spread of excitation, which may be a warning sign for seizures, occurred in one subject and was not accompanied by increased MEP amplitude, suggesting that spread of excitation and amplitude changes are different phenomena and also indicating the need for adequate monitoring even with stimulations at low frequencies.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Electric Stimulation</subject><subject>Evoked Potentials, Motor</subject><subject>Female</subject><subject>Fingers</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Activity - physiology</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Motor Cortex - physiology</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEURoMoWh9Ll0IW4m5qXjOTWUp9QtGNorgJSSaRSGZSkxTtvzelpZt7F9_h494DwDlGU0wwuf4d_ZTxaT3FtON7YIJr0lQNJR_7YIIQ4RXlLT8Cxyl9I1TCtjsEhx2uKeNoAj5vzSKalFwYYbBwCDlEqEPM5g-aP-2yVM67vIJqBX34rWw0P0sz6hXMUY5Jl-Gkh4P8Gk12GqbshqWXufSdggMrfTJn230C3u7vXmeP1fzl4Wl2M680I22u2s60BKPG2r5FiiJlCaKmsaxmCPWKcEWIxD3ta6IJbupe2aZRrPzeM96pnp6Aq03vIoZyW8picEkb7-VowjKJtkME05oXsNqAOoaUorFiEd0g40pgJNYuxfvzXDAuarF2WfiLbfFSDabf0Vt5Jb_c5jJp6W1xoV3aYaThiNGO_gNPsn3r</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>CHEN, R</creator><creator>CLASSEN, J</creator><creator>GERLOFF, C</creator><creator>CELNIK, P</creator><creator>WASSERMANN, E. 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Vestibular system and equilibration</topic><topic>Motor Cortex - physiology</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHEN, R</creatorcontrib><creatorcontrib>CLASSEN, J</creatorcontrib><creatorcontrib>GERLOFF, C</creatorcontrib><creatorcontrib>CELNIK, P</creatorcontrib><creatorcontrib>WASSERMANN, E. M</creatorcontrib><creatorcontrib>HALLETT, M</creatorcontrib><creatorcontrib>COHEN, L. 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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Biological and medical sciences Electric Stimulation Evoked Potentials, Motor Female Fingers Fundamental and applied biological sciences. Psychology Humans Male Middle Aged Motor Activity - physiology Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Motor Cortex - physiology Transcranial Magnetic Stimulation Vertebrates: nervous system and sense organs |
| title | Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation |
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