Pharmacokinetics of Zileuton and Its Metabolites in Patients with Renal Impairment

The pharmacokinetics of zileuton and its conjugated metabolites were evaluated in patients with chronic renal impairment. Five healthy volunteers (creatinine clearance >90 mL/min), five patients with renal failure requiring hemodialysis, six with mild (creatinine clearance, 60–90 mL/min), eight w...

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Veröffentlicht in:	Journal of clinical pharmacology 1997-05, Vol.37 (5), p.395-404
Hauptverfasser:	Awni, Walid M., Wong, Shekman, Chu, Sou-yie, Patterson, Karen, Hansen, Robert, Machinist, Joseph M., Drajesk, Jeff, Keane, William F., Halstenson, Charles E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Female Humans Hydroxyurea - administration & dosage Hydroxyurea - analogs & derivatives Hydroxyurea - pharmacokinetics Kidney Diseases - metabolism Kidney Diseases - physiopathology Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Kidney Function Tests Lipoxygenase Inhibitors - administration & dosage Lipoxygenase Inhibitors - pharmacokinetics Male Medical sciences Middle Aged Pharmacology. Drug treatments Renal Dialysis Respiratory system
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