Effects of Calcium Channel Antagonists on Ca2+Transients in Rat and Canine Cardiomyocytes

First-generation Ca2+channel antagonists depress myocardial contractility, but many of the newer Ca2+channel blockers have a high degree of “vascular selectivity”. This study compares the effects of the Ca2+antagonists felodipine, amlodipine, mibefradil, verapamil and nifedipine, and the Ca2+channel...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 1997-03, Vol.29 (3), p.1037-1043
Hauptverfasser:	Hensley, James, Billman, George E., Johnson, J.David, Hohl, Charlene M., Altschuld, Ruth A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Animals Bay K 8644 Biological Transport Calcium - metabolism Calcium Channel Agonists - pharmacology Calcium channel antagonists Calcium Channel Blockers - pharmacology Canine myocytes Cardiotonic Agents - pharmacology Dogs Dose-Response Relationship, Drug Electric Stimulation Felodipine Female Free calcium transients Heart Ventricles - drug effects Male Mibefradil Myocardium - cytology Myocardium - metabolism Nifedipine Rat myocytes Rats Rats, Sprague-Dawley Species Specificity Verapamil
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