Dipyridamole thallium-201 imaging pre- and post-coronary angioplasty for assessment of regional myocardial ischemia in humans
To examine the effect of coronary angioplasty on myocardial perfusion and to examine anatomic correlates of dipyridamole-thallium images, we performed dipyridamole thallium scanning before and after 24 angioplasty procedures in 23 patients with clinical ischemia. Dipyridamole thallium tomography was...
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| Veröffentlicht in: | Am. Heart J.; (United States) 1989-06, Vol.117 (6), p.1203-1209 |
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| container_title | Am. Heart J.; (United States) |
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| creator | Eichhorn, Eric J. Konstam, Marvin A. Salem, Deeb N. Isner, Jeffrey M. Deckelbaum, Lawrence Stransky, Nicholas B. Metherall, Jeanne A. Toltzis, Hasida I. |
| description | To examine the effect of coronary angioplasty on myocardial perfusion and to examine anatomic correlates of dipyridamole-thallium images, we performed dipyridamole thallium scanning before and after 24 angioplasty procedures in 23 patients with clinical ischemia. Dipyridamole thallium tomography was performed 1 to 4 (mean ± S.D. 1.5 ± 0.9) days before and 1 to 25 (6.3 ± 6.9) days after angioplasty. Coronary angioplasty was anatomically successfull ( |
| doi_str_mv | 10.1016/0002-8703(89)90397-9 |
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Dipyridamole thallium tomography was performed 1 to 4 (mean ± S.D. 1.5 ± 0.9) days before and 1 to 25 (6.3 ± 6.9) days after angioplasty. Coronary angioplasty was anatomically successfull (<50% residual stenosis) in 23 of 24 patients. Before angioplasty, 3 of 24 scans were interpreted as normal, with no change in these patients following angioplasty. Prior to angioplasty, 19 scans showed redistribution. After successful coronary angioplasty in 18 of 19, 17 showed improvement in dipyridamole thallium scanning; one did not show improvement and later required repeat coronary dilatation. In one patient with failed angioplasty, images before and after angioplasty were unchanged. Nine scans showed “fixed” defects before angioplasty, with improvement in three of nine following angioplasty. Quantitative analysis of the dipyridamole thallium scans revealed significant improvement in uptake in the myocardial regions supplied by the successfully dilated artery (involved regions), but not in the remote (uninvolved) regions. We conclude that myocardial perfusion, as judged by dipyridamole thallium scanning, almost always improves following anatomically successful coronary angioplasty. “Fixed” defects may improve following angioplasty and presumably represent ischemia with incomplete redistribution, rather than infarction.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/0002-8703(89)90397-9</identifier><identifier>PMID: 2524953</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics ; Adult ; Aged ; Angioplasty, Balloon ; ARTERIES ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BLOOD CIRCULATION ; BLOOD VESSELS ; BODY ; Cardiology. Vascular system ; CARDIOVASCULAR AGENTS ; CARDIOVASCULAR DISEASES ; CARDIOVASCULAR SYSTEM ; CORONARIES ; Coronary Circulation ; Coronary Disease - diagnostic imaging ; Coronary Disease - physiopathology ; Coronary Disease - therapy ; Coronary heart disease ; COUNTING TECHNIQUES ; DAYS LIVING RADIOISOTOPES ; DIAGNOSIS ; Dipyridamole ; DISEASES ; DRUGS ; ELECTRON CAPTURE RADIOISOTOPES ; Female ; HEART ; Heart - diagnostic imaging ; HEAVY NUCLEI ; Humans ; ISCHEMIA ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; Male ; Medical sciences ; Middle Aged ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANS ; PATIENTS ; PERFUSED ORGANS ; RADIOISOTOPE SCANNING ; RADIOISOTOPES ; RADIOLOGY AND NUCLEAR MEDICINE ; Radionuclide Imaging ; SECONDS LIVING RADIOISOTOPES ; THALLIUM 201 ; THALLIUM ISOTOPES ; Thallium Radioisotopes ; VASCULAR DISEASES ; VASODILATORS</subject><ispartof>Am. Heart J.; (United States), 1989-06, Vol.117 (6), p.1203-1209</ispartof><rights>1989</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-1b12cfee54bf434e5ff7f59340211dfd06f92159dba15652e420c76ebb772a1e3</citedby><cites>FETCH-LOGICAL-c328t-1b12cfee54bf434e5ff7f59340211dfd06f92159dba15652e420c76ebb772a1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-8703(89)90397-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7223668$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2524953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5720544$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Eichhorn, Eric J.</creatorcontrib><creatorcontrib>Konstam, Marvin A.</creatorcontrib><creatorcontrib>Salem, Deeb N.</creatorcontrib><creatorcontrib>Isner, Jeffrey M.</creatorcontrib><creatorcontrib>Deckelbaum, Lawrence</creatorcontrib><creatorcontrib>Stransky, Nicholas B.</creatorcontrib><creatorcontrib>Metherall, Jeanne A.</creatorcontrib><creatorcontrib>Toltzis, Hasida I.</creatorcontrib><title>Dipyridamole thallium-201 imaging pre- and post-coronary angioplasty for assessment of regional myocardial ischemia in humans</title><title>Am. Heart J.; (United States)</title><addtitle>Am Heart J</addtitle><description>To examine the effect of coronary angioplasty on myocardial perfusion and to examine anatomic correlates of dipyridamole-thallium images, we performed dipyridamole thallium scanning before and after 24 angioplasty procedures in 23 patients with clinical ischemia. Dipyridamole thallium tomography was performed 1 to 4 (mean ± S.D. 1.5 ± 0.9) days before and 1 to 25 (6.3 ± 6.9) days after angioplasty. Coronary angioplasty was anatomically successfull (<50% residual stenosis) in 23 of 24 patients. Before angioplasty, 3 of 24 scans were interpreted as normal, with no change in these patients following angioplasty. Prior to angioplasty, 19 scans showed redistribution. After successful coronary angioplasty in 18 of 19, 17 showed improvement in dipyridamole thallium scanning; one did not show improvement and later required repeat coronary dilatation. In one patient with failed angioplasty, images before and after angioplasty were unchanged. Nine scans showed “fixed” defects before angioplasty, with improvement in three of nine following angioplasty. Quantitative analysis of the dipyridamole thallium scans revealed significant improvement in uptake in the myocardial regions supplied by the successfully dilated artery (involved regions), but not in the remote (uninvolved) regions. We conclude that myocardial perfusion, as judged by dipyridamole thallium scanning, almost always improves following anatomically successful coronary angioplasty. “Fixed” defects may improve following angioplasty and presumably represent ischemia with incomplete redistribution, rather than infarction.</description><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>Adult</subject><subject>Aged</subject><subject>Angioplasty, Balloon</subject><subject>ARTERIES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BLOOD CIRCULATION</subject><subject>BLOOD VESSELS</subject><subject>BODY</subject><subject>Cardiology. Vascular system</subject><subject>CARDIOVASCULAR AGENTS</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>CORONARIES</subject><subject>Coronary Circulation</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary Disease - therapy</subject><subject>Coronary heart disease</subject><subject>COUNTING TECHNIQUES</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DIAGNOSIS</subject><subject>Dipyridamole</subject><subject>DISEASES</subject><subject>DRUGS</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>Female</subject><subject>HEART</subject><subject>Heart - diagnostic imaging</subject><subject>HEAVY NUCLEI</subject><subject>Humans</subject><subject>ISCHEMIA</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>PERFUSED ORGANS</subject><subject>RADIOISOTOPE SCANNING</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>SECONDS LIVING RADIOISOTOPES</subject><subject>THALLIUM 201</subject><subject>THALLIUM ISOTOPES</subject><subject>Thallium Radioisotopes</subject><subject>VASCULAR DISEASES</subject><subject>VASODILATORS</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-P1SAQx4nRrG9X_wNNiDEbPVSBQikXk836YzfZxIueCaXDe5gWKrQmPfi_L_W9vKMnBr6fGWa-g9ArSj5QQpuPhBBWtZLU71r1XpFayUo9QTtKStBIzp-i3Rl5ji5z_lWuDWubC3TBBONK1Dv097Of1uR7M8YB8Hwww-CXsWKEYj-avQ97PCWosAk9nmKeKxtTDCat5WXv4zSYPK_YxYRNzpDzCGHG0eEERQ1mwOMarUm9L6HP9gCjN9gHfFhGE_IL9MyZIcPL03mFfn798uP2rnr4_u3-9uahsjVr54p2lFkHIHjneM1BOCedUDUnjNLe9aRxilGh-s5Q0QgGnBErG-g6KZmhUF-hN8e6ZQKvs_Uz2IONIYCdtZCMCM4LdH2EphR_L5BnPZaOYRhMgLhkLVVxvW7bAvIjaFPMOYHTUypmpVVTorfV6M13vfmuW6X_rUarkvb6VH_pRujPSaddFP3tSTfZmsElE6zPZ0wyVjfN9vunIwbFsD8e0jYPBAu9T9s4ffT_7-MRJcuriw</recordid><startdate>198906</startdate><enddate>198906</enddate><creator>Eichhorn, Eric J.</creator><creator>Konstam, Marvin A.</creator><creator>Salem, Deeb N.</creator><creator>Isner, Jeffrey M.</creator><creator>Deckelbaum, Lawrence</creator><creator>Stransky, Nicholas B.</creator><creator>Metherall, Jeanne A.</creator><creator>Toltzis, Hasida I.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198906</creationdate><title>Dipyridamole thallium-201 imaging pre- and post-coronary angioplasty for assessment of regional myocardial ischemia in humans</title><author>Eichhorn, Eric J. ; Konstam, Marvin A. ; Salem, Deeb N. ; Isner, Jeffrey M. ; Deckelbaum, Lawrence ; Stransky, Nicholas B. ; Metherall, Jeanne A. ; Toltzis, Hasida I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-1b12cfee54bf434e5ff7f59340211dfd06f92159dba15652e420c76ebb772a1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>Adult</topic><topic>Aged</topic><topic>Angioplasty, Balloon</topic><topic>ARTERIES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BLOOD CIRCULATION</topic><topic>BLOOD VESSELS</topic><topic>BODY</topic><topic>Cardiology. Vascular system</topic><topic>CARDIOVASCULAR AGENTS</topic><topic>CARDIOVASCULAR DISEASES</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>CORONARIES</topic><topic>Coronary Circulation</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary Disease - therapy</topic><topic>Coronary heart disease</topic><topic>COUNTING TECHNIQUES</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DIAGNOSIS</topic><topic>Dipyridamole</topic><topic>DISEASES</topic><topic>DRUGS</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>Female</topic><topic>HEART</topic><topic>Heart - diagnostic imaging</topic><topic>HEAVY NUCLEI</topic><topic>Humans</topic><topic>ISCHEMIA</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANS</topic><topic>PATIENTS</topic><topic>PERFUSED ORGANS</topic><topic>RADIOISOTOPE SCANNING</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>SECONDS LIVING RADIOISOTOPES</topic><topic>THALLIUM 201</topic><topic>THALLIUM ISOTOPES</topic><topic>Thallium Radioisotopes</topic><topic>VASCULAR DISEASES</topic><topic>VASODILATORS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eichhorn, Eric J.</creatorcontrib><creatorcontrib>Konstam, Marvin A.</creatorcontrib><creatorcontrib>Salem, Deeb N.</creatorcontrib><creatorcontrib>Isner, Jeffrey M.</creatorcontrib><creatorcontrib>Deckelbaum, Lawrence</creatorcontrib><creatorcontrib>Stransky, Nicholas B.</creatorcontrib><creatorcontrib>Metherall, Jeanne A.</creatorcontrib><creatorcontrib>Toltzis, Hasida I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Am. Heart J.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eichhorn, Eric J.</au><au>Konstam, Marvin A.</au><au>Salem, Deeb N.</au><au>Isner, Jeffrey M.</au><au>Deckelbaum, Lawrence</au><au>Stransky, Nicholas B.</au><au>Metherall, Jeanne A.</au><au>Toltzis, Hasida I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dipyridamole thallium-201 imaging pre- and post-coronary angioplasty for assessment of regional myocardial ischemia in humans</atitle><jtitle>Am. Heart J.; (United States)</jtitle><addtitle>Am Heart J</addtitle><date>1989-06</date><risdate>1989</risdate><volume>117</volume><issue>6</issue><spage>1203</spage><epage>1209</epage><pages>1203-1209</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>To examine the effect of coronary angioplasty on myocardial perfusion and to examine anatomic correlates of dipyridamole-thallium images, we performed dipyridamole thallium scanning before and after 24 angioplasty procedures in 23 patients with clinical ischemia. Dipyridamole thallium tomography was performed 1 to 4 (mean ± S.D. 1.5 ± 0.9) days before and 1 to 25 (6.3 ± 6.9) days after angioplasty. Coronary angioplasty was anatomically successfull (<50% residual stenosis) in 23 of 24 patients. Before angioplasty, 3 of 24 scans were interpreted as normal, with no change in these patients following angioplasty. Prior to angioplasty, 19 scans showed redistribution. After successful coronary angioplasty in 18 of 19, 17 showed improvement in dipyridamole thallium scanning; one did not show improvement and later required repeat coronary dilatation. In one patient with failed angioplasty, images before and after angioplasty were unchanged. Nine scans showed “fixed” defects before angioplasty, with improvement in three of nine following angioplasty. Quantitative analysis of the dipyridamole thallium scans revealed significant improvement in uptake in the myocardial regions supplied by the successfully dilated artery (involved regions), but not in the remote (uninvolved) regions. We conclude that myocardial perfusion, as judged by dipyridamole thallium scanning, almost always improves following anatomically successful coronary angioplasty. “Fixed” defects may improve following angioplasty and presumably represent ischemia with incomplete redistribution, rather than infarction.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>2524953</pmid><doi>10.1016/0002-8703(89)90397-9</doi><tpages>7</tpages></addata></record> |
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| ispartof | Am. Heart J.; (United States), 1989-06, Vol.117 (6), p.1203-1209 |
| issn | 0002-8703 1097-6744 |
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| recordid | cdi_proquest_miscellaneous_79016388 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 550601 - Medicine- Unsealed Radionuclides in Diagnostics Adult Aged Angioplasty, Balloon ARTERIES BETA DECAY RADIOISOTOPES Biological and medical sciences BLOOD CIRCULATION BLOOD VESSELS BODY Cardiology. Vascular system CARDIOVASCULAR AGENTS CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM CORONARIES Coronary Circulation Coronary Disease - diagnostic imaging Coronary Disease - physiopathology Coronary Disease - therapy Coronary heart disease COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES DIAGNOSIS Dipyridamole DISEASES DRUGS ELECTRON CAPTURE RADIOISOTOPES Female HEART Heart - diagnostic imaging HEAVY NUCLEI Humans ISCHEMIA ISOMERIC TRANSITION ISOTOPES ISOTOPES Male Medical sciences Middle Aged NUCLEI ODD-EVEN NUCLEI ORGANS PATIENTS PERFUSED ORGANS RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging SECONDS LIVING RADIOISOTOPES THALLIUM 201 THALLIUM ISOTOPES Thallium Radioisotopes VASCULAR DISEASES VASODILATORS |
| title | Dipyridamole thallium-201 imaging pre- and post-coronary angioplasty for assessment of regional myocardial ischemia in humans |
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