Inhibitors of acyl-CoA:cholesterol acyltransferase: novel trisubstituted ureas as hypocholesterolemic agents

Our continued interest in developing novel, potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, and our discovery of several active series of disubstituted urea ACAT inhibitors, have led us to investigate a series of trisubstituted ureas that are structural hybrids of our disubstituted se...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 1997-04, Vol.5 (4), p.739-747
Hauptverfasser:	Purchase, Terri S., Essenburg, Arnold D., Hamelehle, Katherine L., Hes, MaryKay S., Holmes, Ann, Krause, Brian R., Stanfield, Richard L., Trivedi, Bharat K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anticholesteremic Agents - chemical synthesis Anticholesteremic Agents - chemistry Anticholesteremic Agents - pharmacology Anticholesteremic Agents - therapeutic use Benzene Derivatives - chemistry Cholesterol - blood Diet Disease Models, Animal Fluorides - chemistry Hypercholesterolemia - drug therapy Magnetic Resonance Spectroscopy Rabbits Rats Sterol O-Acyltransferase - antagonists & inhibitors Structure-Activity Relationship Urea - analogs & derivatives Urea - chemistry Urea - pharmacology
Online-Zugang:	Volltext
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