Modulation of tumor necrosis factor-alpha gene expression. Desensitization of prostaglandin E2-induced suppression

PGE2, an immune mediator, is an inhibitor of LPS-stimulated TNF production and gene transcription. In the present study we determined whether pretreatment with PGE2 could desensitize the suppressive function of PGE2 for the production of macrophage (MO)-derived TNF. CFA-elicited MO were incubated wi...

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Veröffentlicht in:	The Journal of immunology (1950) 1989-06, Vol.142 (12), p.4346-4350
Hauptverfasser:	Spengler, RN, Spengler, ML, Strieter, RM, Remick, DG, Larrick, JW, Kunkel, SL
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - physiology Animals Desensitization, Immunologic Dinoprostone - immunology Dinoprostone - physiology Dose-Response Relationship, Immunologic Female Gene Expression Regulation - drug effects Immunosuppressive Agents - physiology Indomethacin - pharmacology Lipopolysaccharides Macrophages - metabolism Mice Mice, Inbred CBA Time Factors Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
Online-Zugang:	Volltext
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