Factors Associated With Human Papillomavirus Infection Detected by Polymerase Chain Reaction Among Urban Canadian Aboriginal and Non-Aboriginal Women
Objectives: To determine the prevalence and correlates of human papillomavirus (HPV) infection among women attending an ethnically mixed, predominantly low-income, inner-city primary care clinic. Study Design: Cross-sectional survey (N = 1,477). Demographic, behavioral, and reproductive history data...
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| Veröffentlicht in: | Sexually transmitted diseases 1997-05, Vol.24 (5), p.293-298 |
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| creator | YOUNG, T. KUE MCNICOL, PATRICIA BEAUVAIS, JANET |
| description | Objectives: To determine the prevalence and correlates of human papillomavirus (HPV) infection among women attending an ethnically mixed, predominantly low-income, inner-city primary care clinic. Study Design: Cross-sectional survey (N = 1,477). Demographic, behavioral, and reproductive history data were collected by questionnaire. Cervical swabs were analyzed for gonorrhea and chlamydial infections, abnormal cytology, and HPV infection assessed by PCR followed by hybridization for types 6, 11, 16, 18, 31, 33, and 35. Results: Human papillomavirus was detected in 33% of specimens, with no significant difference between Aboriginal (AB) and non-Aboriginal women. Adjusting for AB status, HPV infection was associated with marital status, condom use, number of sexual partners (last year and lifetime), age at first sexual intercourse, a history of sexual abuse, and current abnormal Papanicolaou (Pap) smear. In multivariate analyses excluding abnormal Pap smear as an independent variable, marital status and the number of lifetime sexual partners were found to be significant independent predictors of HPV infection. Comparing individuals with 20+ lifetime sexual partners and those with 1 or fewer partners, the odds ratio (OR) for HPV infection was 1.90 (95% confidence interval [CI] 1.66-2.17) among AB women and 1.54 among non-AB women (95% CI 1.36-1.73). The OR for infection with HPV types 6 and 11 was 1.39 (95% CI 1.221.58), whereas for the high oncogenic risk types of 16, 18, 31, 33, and 35, the OR was 1.82 (95% CI 1.65-2.01). Conclusions: No differences were found between AB and nonAB women in the detection of HPV DNA, despite the higher risk for cervical cancer and the prevalence of recognized behavioral and reproductive risk factors among AB women. This study also indicates that the association of sexual activity with HPV infection holds true for both high- and low-oncogenic HPV types. |
| doi_str_mv | 10.1097/00007435-199705000-00011 |
| format | Article |
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KUE ; MCNICOL, PATRICIA ; BEAUVAIS, JANET</creator><creatorcontrib>YOUNG, T. KUE ; MCNICOL, PATRICIA ; BEAUVAIS, JANET</creatorcontrib><description>Objectives: To determine the prevalence and correlates of human papillomavirus (HPV) infection among women attending an ethnically mixed, predominantly low-income, inner-city primary care clinic. Study Design: Cross-sectional survey (N = 1,477). Demographic, behavioral, and reproductive history data were collected by questionnaire. Cervical swabs were analyzed for gonorrhea and chlamydial infections, abnormal cytology, and HPV infection assessed by PCR followed by hybridization for types 6, 11, 16, 18, 31, 33, and 35. Results: Human papillomavirus was detected in 33% of specimens, with no significant difference between Aboriginal (AB) and non-Aboriginal women. Adjusting for AB status, HPV infection was associated with marital status, condom use, number of sexual partners (last year and lifetime), age at first sexual intercourse, a history of sexual abuse, and current abnormal Papanicolaou (Pap) smear. In multivariate analyses excluding abnormal Pap smear as an independent variable, marital status and the number of lifetime sexual partners were found to be significant independent predictors of HPV infection. Comparing individuals with 20+ lifetime sexual partners and those with 1 or fewer partners, the odds ratio (OR) for HPV infection was 1.90 (95% confidence interval [CI] 1.66-2.17) among AB women and 1.54 among non-AB women (95% CI 1.36-1.73). The OR for infection with HPV types 6 and 11 was 1.39 (95% CI 1.221.58), whereas for the high oncogenic risk types of 16, 18, 31, 33, and 35, the OR was 1.82 (95% CI 1.65-2.01). Conclusions: No differences were found between AB and nonAB women in the detection of HPV DNA, despite the higher risk for cervical cancer and the prevalence of recognized behavioral and reproductive risk factors among AB women. This study also indicates that the association of sexual activity with HPV infection holds true for both high- and low-oncogenic HPV types.</description><identifier>ISSN: 0148-5717</identifier><identifier>EISSN: 1537-4521</identifier><identifier>DOI: 10.1097/00007435-199705000-00011</identifier><identifier>PMID: 9153740</identifier><identifier>CODEN: STRDDM</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>American Native Continental Ancestry Group ; Biological and medical sciences ; Cross-Sectional Studies ; DNA, Viral - analysis ; Female ; Human viral diseases ; Humans ; Indigenous people ; Infectious diseases ; Manitoba - epidemiology ; Manitoba - ethnology ; Medical sciences ; Multivariate Analysis ; Papillomaviridae - genetics ; Papillomavirus Infections - diagnosis ; Papillomavirus Infections - epidemiology ; Polymerase Chain Reaction ; Prevalence ; Risk Factors ; Sexually transmitted diseases ; Socioeconomic Factors ; STD ; Urban Population ; Uterine Cervical Neoplasms - etiology ; Uterine Cervical Neoplasms - prevention & control ; Viral diseases ; Viral diseases of the genital and urinary system ; Women</subject><ispartof>Sexually transmitted diseases, 1997-05, Vol.24 (5), p.293-298</ispartof><rights>Copyright 1997 American Sexually Transmitted Diseases Association</rights><rights>1997 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins May 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-9c1aeeb7d03fe5f9a6a59b75a7869031343c79ae1ed30ca47175111ee1ca778d3</citedby><cites>FETCH-LOGICAL-c3531-9c1aeeb7d03fe5f9a6a59b75a7869031343c79ae1ed30ca47175111ee1ca778d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/44964940$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/44964940$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,30998,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2674966$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9153740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOUNG, T. KUE</creatorcontrib><creatorcontrib>MCNICOL, PATRICIA</creatorcontrib><creatorcontrib>BEAUVAIS, JANET</creatorcontrib><title>Factors Associated With Human Papillomavirus Infection Detected by Polymerase Chain Reaction Among Urban Canadian Aboriginal and Non-Aboriginal Women</title><title>Sexually transmitted diseases</title><addtitle>Sex Transm Dis</addtitle><description>Objectives: To determine the prevalence and correlates of human papillomavirus (HPV) infection among women attending an ethnically mixed, predominantly low-income, inner-city primary care clinic. Study Design: Cross-sectional survey (N = 1,477). Demographic, behavioral, and reproductive history data were collected by questionnaire. Cervical swabs were analyzed for gonorrhea and chlamydial infections, abnormal cytology, and HPV infection assessed by PCR followed by hybridization for types 6, 11, 16, 18, 31, 33, and 35. Results: Human papillomavirus was detected in 33% of specimens, with no significant difference between Aboriginal (AB) and non-Aboriginal women. Adjusting for AB status, HPV infection was associated with marital status, condom use, number of sexual partners (last year and lifetime), age at first sexual intercourse, a history of sexual abuse, and current abnormal Papanicolaou (Pap) smear. In multivariate analyses excluding abnormal Pap smear as an independent variable, marital status and the number of lifetime sexual partners were found to be significant independent predictors of HPV infection. Comparing individuals with 20+ lifetime sexual partners and those with 1 or fewer partners, the odds ratio (OR) for HPV infection was 1.90 (95% confidence interval [CI] 1.66-2.17) among AB women and 1.54 among non-AB women (95% CI 1.36-1.73). The OR for infection with HPV types 6 and 11 was 1.39 (95% CI 1.221.58), whereas for the high oncogenic risk types of 16, 18, 31, 33, and 35, the OR was 1.82 (95% CI 1.65-2.01). Conclusions: No differences were found between AB and nonAB women in the detection of HPV DNA, despite the higher risk for cervical cancer and the prevalence of recognized behavioral and reproductive risk factors among AB women. 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KUE ; MCNICOL, PATRICIA ; BEAUVAIS, JANET</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-9c1aeeb7d03fe5f9a6a59b75a7869031343c79ae1ed30ca47175111ee1ca778d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>American Native Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Indigenous people</topic><topic>Infectious diseases</topic><topic>Manitoba - epidemiology</topic><topic>Manitoba - ethnology</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomavirus Infections - diagnosis</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Polymerase Chain Reaction</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Sexually transmitted diseases</topic><topic>Socioeconomic Factors</topic><topic>STD</topic><topic>Urban Population</topic><topic>Uterine Cervical Neoplasms - etiology</topic><topic>Uterine Cervical Neoplasms - prevention & control</topic><topic>Viral diseases</topic><topic>Viral diseases of the genital and urinary system</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YOUNG, T. KUE</creatorcontrib><creatorcontrib>MCNICOL, PATRICIA</creatorcontrib><creatorcontrib>BEAUVAIS, JANET</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Sexually transmitted diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOUNG, T. KUE</au><au>MCNICOL, PATRICIA</au><au>BEAUVAIS, JANET</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Associated With Human Papillomavirus Infection Detected by Polymerase Chain Reaction Among Urban Canadian Aboriginal and Non-Aboriginal Women</atitle><jtitle>Sexually transmitted diseases</jtitle><addtitle>Sex Transm Dis</addtitle><date>1997-05</date><risdate>1997</risdate><volume>24</volume><issue>5</issue><spage>293</spage><epage>298</epage><pages>293-298</pages><issn>0148-5717</issn><eissn>1537-4521</eissn><coden>STRDDM</coden><abstract>Objectives: To determine the prevalence and correlates of human papillomavirus (HPV) infection among women attending an ethnically mixed, predominantly low-income, inner-city primary care clinic. Study Design: Cross-sectional survey (N = 1,477). Demographic, behavioral, and reproductive history data were collected by questionnaire. Cervical swabs were analyzed for gonorrhea and chlamydial infections, abnormal cytology, and HPV infection assessed by PCR followed by hybridization for types 6, 11, 16, 18, 31, 33, and 35. Results: Human papillomavirus was detected in 33% of specimens, with no significant difference between Aboriginal (AB) and non-Aboriginal women. Adjusting for AB status, HPV infection was associated with marital status, condom use, number of sexual partners (last year and lifetime), age at first sexual intercourse, a history of sexual abuse, and current abnormal Papanicolaou (Pap) smear. In multivariate analyses excluding abnormal Pap smear as an independent variable, marital status and the number of lifetime sexual partners were found to be significant independent predictors of HPV infection. Comparing individuals with 20+ lifetime sexual partners and those with 1 or fewer partners, the odds ratio (OR) for HPV infection was 1.90 (95% confidence interval [CI] 1.66-2.17) among AB women and 1.54 among non-AB women (95% CI 1.36-1.73). The OR for infection with HPV types 6 and 11 was 1.39 (95% CI 1.221.58), whereas for the high oncogenic risk types of 16, 18, 31, 33, and 35, the OR was 1.82 (95% CI 1.65-2.01). Conclusions: No differences were found between AB and nonAB women in the detection of HPV DNA, despite the higher risk for cervical cancer and the prevalence of recognized behavioral and reproductive risk factors among AB women. This study also indicates that the association of sexual activity with HPV infection holds true for both high- and low-oncogenic HPV types.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9153740</pmid><doi>10.1097/00007435-199705000-00011</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | American Native Continental Ancestry Group Biological and medical sciences Cross-Sectional Studies DNA, Viral - analysis Female Human viral diseases Humans Indigenous people Infectious diseases Manitoba - epidemiology Manitoba - ethnology Medical sciences Multivariate Analysis Papillomaviridae - genetics Papillomavirus Infections - diagnosis Papillomavirus Infections - epidemiology Polymerase Chain Reaction Prevalence Risk Factors Sexually transmitted diseases Socioeconomic Factors STD Urban Population Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - prevention & control Viral diseases Viral diseases of the genital and urinary system Women |
| title | Factors Associated With Human Papillomavirus Infection Detected by Polymerase Chain Reaction Among Urban Canadian Aboriginal and Non-Aboriginal Women |
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