Intracellular Location of Thymidylate Synthase and Its State of Phosphorylation

Thymidylate synthase (TS), an enzyme that is essential for DNA synthesis, was found to be associated mainly with the nucleolar region of H35 rat hepatoma cells, as determined both by immunogold electron microscopy and by autoradiography. In the latter case, the location of TS was established through...

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Veröffentlicht in:	The Journal of biological chemistry 1997-05, Vol.272 (20), p.13281-13285
Hauptverfasser:	Samsonoff, William A., Reston, James, McKee, Mary, O'Connor, Brigid, Galivan, John, Maley, Gladys, Maley, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Cell Division Cell Nucleus - enzymology Immunohistochemistry Liver Neoplasms, Experimental - enzymology Liver Neoplasms, Experimental - pathology Phosphorylation Rats Thymidylate Synthase - analysis Thymidylate Synthase - metabolism Tumor Cells, Cultured
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