Brain and Spinal Cord Levels of Histamine in Lewis Rats with Acute Experimental Autoimmune Encephalomyelitis
: Acute experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with guinea pig spinal cord homogenate emulsified with Mycobacterium tuberculosis‐enriched complete Freund's adjuvant (CFA). Control rats were inoculated with CFA alone. Control and EAE rats were ki...
Gespeichert in:
| Veröffentlicht in: | Journal of neurochemistry 1989-07, Vol.53 (1), p.111-118 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 118 |
|---|---|
| container_issue | 1 |
| container_start_page | 111 |
| container_title | Journal of neurochemistry |
| container_volume | 53 |
| creator | Orr, Edward L. Stanley, Nancy C. |
| description | : Acute experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with guinea pig spinal cord homogenate emulsified with Mycobacterium tuberculosis‐enriched complete Freund's adjuvant (CFA). Control rats were inoculated with CFA alone. Control and EAE rats were killed on days 7,9, 11, and 13 postinoculation, and regional brain and spinal cord levels of histamine were determined. No regional differences in histamine content between control and EAE rats were seen on day 7 or 9 post‐inoculation. However, depending on the region, EAE rats exhibited significantly higher levels of histamine in their CNS on day 11 or 13 postinoculation or on both. Thus, regionally and temporally specific increases in brain and spinal cord levels of histamine develop concomitant with or just after the appearance (on day 10 postinoculation) of clinical signs of acute EAE, a finding suggesting that histamine may be involved in the development or expression of acute EAE in Lewis rats. |
| doi_str_mv | 10.1111/j.1471-4159.1989.tb07301.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79013753</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79013753</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3991-ad747a7b1766a0f9eb5e1b71e89a6c6eef2da7848767553050daf0fa0b34dd553</originalsourceid><addsrcrecordid>eNqVkFtr3DAQRkVpSTeXn1AQhfbNruSLZOUhsF22TcvSQNo8i7E9JlrkSyw5u_vvo2VN8ly9CDTn08wcQj5zFvNwvm1jnkkeZTxXMVeFin3JZMp4vH9HFq-l92TBWJJEKcuSj-TcuS1jXGSCn5GzRBaC5dmC2O8jmI5CV9O_g-nA0lU_1nSDz2gd7Rt6a5yH1nRIA7bBnXH0HryjO-Mf6bKaPNL1fsDRtNj5EF9OvjdtO4XAuqtweATbtwe0xht3ST40YB1ezfcFefix_re6jTZ3P3-tlpuoSpXiEdQykyBLLoUA1igsc-Sl5FgoEJVAbJIaZJEVUsg8T1nOamhYA6xMs7oOLxfk6-nfYeyfJnRet8ZVaC102E9OS8V4KvM0gNcnsBp750Zs9BAWgfGgOdNH1Xqrjz710ac-qtazar0P4U9zl6lssX6Nzm5D_ctcB1eBbUboKuPeOqg8CeuKwN2cuJ2xePiPCfTvP6tApC8M3Jxh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79013753</pqid></control><display><type>article</type><title>Brain and Spinal Cord Levels of Histamine in Lewis Rats with Acute Experimental Autoimmune Encephalomyelitis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Orr, Edward L. ; Stanley, Nancy C.</creator><creatorcontrib>Orr, Edward L. ; Stanley, Nancy C.</creatorcontrib><description>: Acute experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with guinea pig spinal cord homogenate emulsified with Mycobacterium tuberculosis‐enriched complete Freund's adjuvant (CFA). Control rats were inoculated with CFA alone. Control and EAE rats were killed on days 7,9, 11, and 13 postinoculation, and regional brain and spinal cord levels of histamine were determined. No regional differences in histamine content between control and EAE rats were seen on day 7 or 9 post‐inoculation. However, depending on the region, EAE rats exhibited significantly higher levels of histamine in their CNS on day 11 or 13 postinoculation or on both. Thus, regionally and temporally specific increases in brain and spinal cord levels of histamine develop concomitant with or just after the appearance (on day 10 postinoculation) of clinical signs of acute EAE, a finding suggesting that histamine may be involved in the development or expression of acute EAE in Lewis rats.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.1989.tb07301.x</identifier><identifier>PMID: 2786054</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acute Disease ; Acute experimental autoimmune encephalomyelitis ; Animals ; Biological and medical sciences ; Brain - metabolism ; Brain - pathology ; Encephalomyelitis, Autoimmune, Experimental - metabolism ; Encephalomyelitis, Autoimmune, Experimental - pathology ; Histamine ; Histamine - metabolism ; Histaminergic neurons ; Male ; Mast cells ; Medical sciences ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Organ Size ; Rats ; Rats, Inbred Lew ; Spinal Cord - metabolism ; Spinal Cord - pathology ; Time Factors ; Tissue Distribution</subject><ispartof>Journal of neurochemistry, 1989-07, Vol.53 (1), p.111-118</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3991-ad747a7b1766a0f9eb5e1b71e89a6c6eef2da7848767553050daf0fa0b34dd553</citedby><cites>FETCH-LOGICAL-c3991-ad747a7b1766a0f9eb5e1b71e89a6c6eef2da7848767553050daf0fa0b34dd553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.1989.tb07301.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.1989.tb07301.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19523996$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2786054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orr, Edward L.</creatorcontrib><creatorcontrib>Stanley, Nancy C.</creatorcontrib><title>Brain and Spinal Cord Levels of Histamine in Lewis Rats with Acute Experimental Autoimmune Encephalomyelitis</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: Acute experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with guinea pig spinal cord homogenate emulsified with Mycobacterium tuberculosis‐enriched complete Freund's adjuvant (CFA). Control rats were inoculated with CFA alone. Control and EAE rats were killed on days 7,9, 11, and 13 postinoculation, and regional brain and spinal cord levels of histamine were determined. No regional differences in histamine content between control and EAE rats were seen on day 7 or 9 post‐inoculation. However, depending on the region, EAE rats exhibited significantly higher levels of histamine in their CNS on day 11 or 13 postinoculation or on both. Thus, regionally and temporally specific increases in brain and spinal cord levels of histamine develop concomitant with or just after the appearance (on day 10 postinoculation) of clinical signs of acute EAE, a finding suggesting that histamine may be involved in the development or expression of acute EAE in Lewis rats.</description><subject>Acute Disease</subject><subject>Acute experimental autoimmune encephalomyelitis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - metabolism</subject><subject>Encephalomyelitis, Autoimmune, Experimental - pathology</subject><subject>Histamine</subject><subject>Histamine - metabolism</subject><subject>Histaminergic neurons</subject><subject>Male</subject><subject>Mast cells</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Organ Size</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Spinal Cord - metabolism</subject><subject>Spinal Cord - pathology</subject><subject>Time Factors</subject><subject>Tissue Distribution</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFtr3DAQRkVpSTeXn1AQhfbNruSLZOUhsF22TcvSQNo8i7E9JlrkSyw5u_vvo2VN8ly9CDTn08wcQj5zFvNwvm1jnkkeZTxXMVeFin3JZMp4vH9HFq-l92TBWJJEKcuSj-TcuS1jXGSCn5GzRBaC5dmC2O8jmI5CV9O_g-nA0lU_1nSDz2gd7Rt6a5yH1nRIA7bBnXH0HryjO-Mf6bKaPNL1fsDRtNj5EF9OvjdtO4XAuqtweATbtwe0xht3ST40YB1ezfcFefix_re6jTZ3P3-tlpuoSpXiEdQykyBLLoUA1igsc-Sl5FgoEJVAbJIaZJEVUsg8T1nOamhYA6xMs7oOLxfk6-nfYeyfJnRet8ZVaC102E9OS8V4KvM0gNcnsBp750Zs9BAWgfGgOdNH1Xqrjz710ac-qtazar0P4U9zl6lssX6Nzm5D_ctcB1eBbUboKuPeOqg8CeuKwN2cuJ2xePiPCfTvP6tApC8M3Jxh</recordid><startdate>198907</startdate><enddate>198907</enddate><creator>Orr, Edward L.</creator><creator>Stanley, Nancy C.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198907</creationdate><title>Brain and Spinal Cord Levels of Histamine in Lewis Rats with Acute Experimental Autoimmune Encephalomyelitis</title><author>Orr, Edward L. ; Stanley, Nancy C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3991-ad747a7b1766a0f9eb5e1b71e89a6c6eef2da7848767553050daf0fa0b34dd553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acute Disease</topic><topic>Acute experimental autoimmune encephalomyelitis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - metabolism</topic><topic>Encephalomyelitis, Autoimmune, Experimental - pathology</topic><topic>Histamine</topic><topic>Histamine - metabolism</topic><topic>Histaminergic neurons</topic><topic>Male</topic><topic>Mast cells</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Organ Size</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Spinal Cord - metabolism</topic><topic>Spinal Cord - pathology</topic><topic>Time Factors</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orr, Edward L.</creatorcontrib><creatorcontrib>Stanley, Nancy C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orr, Edward L.</au><au>Stanley, Nancy C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain and Spinal Cord Levels of Histamine in Lewis Rats with Acute Experimental Autoimmune Encephalomyelitis</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1989-07</date><risdate>1989</risdate><volume>53</volume><issue>1</issue><spage>111</spage><epage>118</epage><pages>111-118</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: Acute experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with guinea pig spinal cord homogenate emulsified with Mycobacterium tuberculosis‐enriched complete Freund's adjuvant (CFA). Control rats were inoculated with CFA alone. Control and EAE rats were killed on days 7,9, 11, and 13 postinoculation, and regional brain and spinal cord levels of histamine were determined. No regional differences in histamine content between control and EAE rats were seen on day 7 or 9 post‐inoculation. However, depending on the region, EAE rats exhibited significantly higher levels of histamine in their CNS on day 11 or 13 postinoculation or on both. Thus, regionally and temporally specific increases in brain and spinal cord levels of histamine develop concomitant with or just after the appearance (on day 10 postinoculation) of clinical signs of acute EAE, a finding suggesting that histamine may be involved in the development or expression of acute EAE in Lewis rats.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2786054</pmid><doi>10.1111/j.1471-4159.1989.tb07301.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3042 |
| ispartof | Journal of neurochemistry, 1989-07, Vol.53 (1), p.111-118 |
| issn | 0022-3042 1471-4159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79013753 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acute Disease Acute experimental autoimmune encephalomyelitis Animals Biological and medical sciences Brain - metabolism Brain - pathology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Histamine Histamine - metabolism Histaminergic neurons Male Mast cells Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Organ Size Rats Rats, Inbred Lew Spinal Cord - metabolism Spinal Cord - pathology Time Factors Tissue Distribution |
| title | Brain and Spinal Cord Levels of Histamine in Lewis Rats with Acute Experimental Autoimmune Encephalomyelitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T16%3A39%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Brain%20and%20Spinal%20Cord%20Levels%20of%20Histamine%20in%20Lewis%20Rats%20with%20Acute%20Experimental%20Autoimmune%20Encephalomyelitis&rft.jtitle=Journal%20of%20neurochemistry&rft.au=Orr,%20Edward%20L.&rft.date=1989-07&rft.volume=53&rft.issue=1&rft.spage=111&rft.epage=118&rft.pages=111-118&rft.issn=0022-3042&rft.eissn=1471-4159&rft.coden=JONRA9&rft_id=info:doi/10.1111/j.1471-4159.1989.tb07301.x&rft_dat=%3Cproquest_cross%3E79013753%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79013753&rft_id=info:pmid/2786054&rfr_iscdi=true |