Complete sequence of the UPP gene encoding uracil phosphoribosyltransferase from Mycobacterium bovis BCG
The nucleotide sequence of a 799 bp fragment of Mycobacterium bovis BCG containing the putative upp gene that encodes a uracil phosphoribosyltransferase (UPRTase [EC 2.4.2.9]) has been determined. The upp gene of BCG has an open reading frame (ORF) of 621 bp (207 amino acids) starting with GTG (posi...
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| Veröffentlicht in: | Biochemistry and molecular biology international 1997-05, Vol.41 (6), p.1117-1124 |
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| container_title | Biochemistry and molecular biology international |
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| creator | Kim, J.K Kim, J.H Lee, S.H Kang, Y Lim, J.S Lee, H.G Kim, S.J Bai, G.H Park, Y.K Cho, S.H |
| description | The nucleotide sequence of a 799 bp fragment of Mycobacterium bovis BCG containing the putative upp gene that encodes a uracil phosphoribosyltransferase (UPRTase [EC 2.4.2.9]) has been determined. The upp gene of BCG has an open reading frame (ORF) of 621 bp (207 amino acids) starting with GTG (position 112) and ending with TGA (position 733), and its molecular mass was calculated to be 21,864 Da. Comparative analyses of the deduced amino acid sequence of BCG UPRTase with the UPRTase of six bacterial genera revealed that 24% (50/211) of the residues are perfectly conserved and 32% (67/211) of the residues are well conserved. |
| doi_str_mv | 10.1080/15216549700202201 |
| format | Article |
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The upp gene of BCG has an open reading frame (ORF) of 621 bp (207 amino acids) starting with GTG (position 112) and ending with TGA (position 733), and its molecular mass was calculated to be 21,864 Da. Comparative analyses of the deduced amino acid sequence of BCG UPRTase with the UPRTase of six bacterial genera revealed that 24% (50/211) of the residues are perfectly conserved and 32% (67/211) of the residues are well conserved.</description><identifier>ISSN: 1039-9712</identifier><identifier>ISSN: 1521-6543</identifier><identifier>EISSN: 1521-6551</identifier><identifier>DOI: 10.1080/15216549700202201</identifier><identifier>PMID: 9161706</identifier><language>eng</language><publisher>UK: Informa Healthcare</publisher><subject>Amino Acid Sequence ; amino acid sequences ; Base Sequence ; BCG ; BCG vaccine ; Cloning, Molecular ; DNA Transposable Elements ; DNA, Recombinant ; genbank/u77913 ; genes ; Genes, Bacterial ; Genomic Library ; Molecular Sequence Data ; Molecular Weight ; Mycobacterium bovis ; Mycobacterium bovis - chemistry ; Mycobacterium bovis - enzymology ; Mycobacterium bovis - genetics ; nucleotide sequences ; Pentosyltransferases - chemistry ; Pentosyltransferases - genetics ; Sequence Alignment ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; upp ; uracil phosphoribosyltransferase</subject><ispartof>Biochemistry and molecular biology international, 1997-05, Vol.41 (6), p.1117-1124</ispartof><rights>Copyright © 1997 International Union of Biochemistry and Molecular Biology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1080%2F15216549700202201$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1080%2F15216549700202201$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9161706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, J.K</creatorcontrib><creatorcontrib>Kim, J.H</creatorcontrib><creatorcontrib>Lee, S.H</creatorcontrib><creatorcontrib>Kang, Y</creatorcontrib><creatorcontrib>Lim, J.S</creatorcontrib><creatorcontrib>Lee, H.G</creatorcontrib><creatorcontrib>Kim, S.J</creatorcontrib><creatorcontrib>Bai, G.H</creatorcontrib><creatorcontrib>Park, Y.K</creatorcontrib><creatorcontrib>Cho, S.H</creatorcontrib><title>Complete sequence of the UPP gene encoding uracil phosphoribosyltransferase from Mycobacterium bovis BCG</title><title>Biochemistry and molecular biology international</title><addtitle>Biochem Mol Biol Int</addtitle><description>The nucleotide sequence of a 799 bp fragment of Mycobacterium bovis BCG containing the putative upp gene that encodes a uracil phosphoribosyltransferase (UPRTase [EC 2.4.2.9]) has been determined. The upp gene of BCG has an open reading frame (ORF) of 621 bp (207 amino acids) starting with GTG (position 112) and ending with TGA (position 733), and its molecular mass was calculated to be 21,864 Da. Comparative analyses of the deduced amino acid sequence of BCG UPRTase with the UPRTase of six bacterial genera revealed that 24% (50/211) of the residues are perfectly conserved and 32% (67/211) of the residues are well conserved.</description><subject>Amino Acid Sequence</subject><subject>amino acid sequences</subject><subject>Base Sequence</subject><subject>BCG</subject><subject>BCG vaccine</subject><subject>Cloning, Molecular</subject><subject>DNA Transposable Elements</subject><subject>DNA, Recombinant</subject><subject>genbank/u77913</subject><subject>genes</subject><subject>Genes, Bacterial</subject><subject>Genomic Library</subject><subject>Molecular Sequence Data</subject><subject>Molecular Weight</subject><subject>Mycobacterium bovis</subject><subject>Mycobacterium bovis - chemistry</subject><subject>Mycobacterium bovis - enzymology</subject><subject>Mycobacterium bovis - genetics</subject><subject>nucleotide sequences</subject><subject>Pentosyltransferases - chemistry</subject><subject>Pentosyltransferases - genetics</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>upp</subject><subject>uracil phosphoribosyltransferase</subject><issn>1039-9712</issn><issn>1521-6543</issn><issn>1521-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUE1v1DAQjRCotIUfwAHhE7fA2I6_JC7sClqkVlSie7YcZ7xrlMSLnRTtvyerXXHhwGE0o_fmvdG8qnpD4QMFDR-pYFSKxigABowBfVZdHrFaCkGfLzNwUxtF2cvqqpSfABw4ay6qC0MlVSAvq906DfseJyQFf804eiQpkGmHZPPwQLY4IlnA1MVxS-bsfOzJfpfKUjm2qRz6KbuxBMyuIAk5DeT-4FPr_IQ5zgNp01MsZLW-eVW9CK4v-Prcr6vN1y-P69v67vvNt_Xnu9pzBarmXeelM8qbRhvhFTNO68YwwZh0LCC0KnRBtI0BxQN1ouUoWw0UwTAeGL-u3p989zktD5XJDrF47Hs3YpqLVQYoSM2XRXpa9DmVkjHYfY6DywdLwR7Ttf-ku2jens3ndsDur-Ic58J_OvG_Y4-H_xvax9X9SgnKaCOkWuTvTvLgknXbHIvd_DjeBaalZo3mfwABjY6u</recordid><startdate>199705</startdate><enddate>199705</enddate><creator>Kim, J.K</creator><creator>Kim, J.H</creator><creator>Lee, S.H</creator><creator>Kang, Y</creator><creator>Lim, J.S</creator><creator>Lee, H.G</creator><creator>Kim, S.J</creator><creator>Bai, G.H</creator><creator>Park, Y.K</creator><creator>Cho, S.H</creator><general>Informa Healthcare</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199705</creationdate><title>Complete sequence of the UPP gene encoding uracil phosphoribosyltransferase from Mycobacterium bovis BCG</title><author>Kim, J.K ; Kim, J.H ; Lee, S.H ; Kang, Y ; Lim, J.S ; Lee, H.G ; Kim, S.J ; Bai, G.H ; Park, Y.K ; Cho, S.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3707-3ddc6a97c94895c729a884925226a2fe0b7fdf5b49073f1a5b3e6b801e0923f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amino Acid Sequence</topic><topic>amino acid sequences</topic><topic>Base Sequence</topic><topic>BCG</topic><topic>BCG vaccine</topic><topic>Cloning, Molecular</topic><topic>DNA Transposable Elements</topic><topic>DNA, Recombinant</topic><topic>genbank/u77913</topic><topic>genes</topic><topic>Genes, Bacterial</topic><topic>Genomic Library</topic><topic>Molecular Sequence Data</topic><topic>Molecular Weight</topic><topic>Mycobacterium bovis</topic><topic>Mycobacterium bovis - chemistry</topic><topic>Mycobacterium bovis - enzymology</topic><topic>Mycobacterium bovis - genetics</topic><topic>nucleotide sequences</topic><topic>Pentosyltransferases - chemistry</topic><topic>Pentosyltransferases - genetics</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>upp</topic><topic>uracil phosphoribosyltransferase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, J.K</creatorcontrib><creatorcontrib>Kim, J.H</creatorcontrib><creatorcontrib>Lee, S.H</creatorcontrib><creatorcontrib>Kang, Y</creatorcontrib><creatorcontrib>Lim, J.S</creatorcontrib><creatorcontrib>Lee, H.G</creatorcontrib><creatorcontrib>Kim, S.J</creatorcontrib><creatorcontrib>Bai, G.H</creatorcontrib><creatorcontrib>Park, Y.K</creatorcontrib><creatorcontrib>Cho, S.H</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemistry and molecular biology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, J.K</au><au>Kim, J.H</au><au>Lee, S.H</au><au>Kang, Y</au><au>Lim, J.S</au><au>Lee, H.G</au><au>Kim, S.J</au><au>Bai, G.H</au><au>Park, Y.K</au><au>Cho, S.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complete sequence of the UPP gene encoding uracil phosphoribosyltransferase from Mycobacterium bovis BCG</atitle><jtitle>Biochemistry and molecular biology international</jtitle><addtitle>Biochem Mol Biol Int</addtitle><date>1997-05</date><risdate>1997</risdate><volume>41</volume><issue>6</issue><spage>1117</spage><epage>1124</epage><pages>1117-1124</pages><issn>1039-9712</issn><issn>1521-6543</issn><eissn>1521-6551</eissn><abstract>The nucleotide sequence of a 799 bp fragment of Mycobacterium bovis BCG containing the putative upp gene that encodes a uracil phosphoribosyltransferase (UPRTase [EC 2.4.2.9]) has been determined. The upp gene of BCG has an open reading frame (ORF) of 621 bp (207 amino acids) starting with GTG (position 112) and ending with TGA (position 733), and its molecular mass was calculated to be 21,864 Da. Comparative analyses of the deduced amino acid sequence of BCG UPRTase with the UPRTase of six bacterial genera revealed that 24% (50/211) of the residues are perfectly conserved and 32% (67/211) of the residues are well conserved.</abstract><cop>UK</cop><pub>Informa Healthcare</pub><pmid>9161706</pmid><doi>10.1080/15216549700202201</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence amino acid sequences Base Sequence BCG BCG vaccine Cloning, Molecular DNA Transposable Elements DNA, Recombinant genbank/u77913 genes Genes, Bacterial Genomic Library Molecular Sequence Data Molecular Weight Mycobacterium bovis Mycobacterium bovis - chemistry Mycobacterium bovis - enzymology Mycobacterium bovis - genetics nucleotide sequences Pentosyltransferases - chemistry Pentosyltransferases - genetics Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid upp uracil phosphoribosyltransferase |
| title | Complete sequence of the UPP gene encoding uracil phosphoribosyltransferase from Mycobacterium bovis BCG |
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