Inhibition of GH Releasing Factor (GRF)-Induced GH Secretion by Intraruminal Infusion of Volatile Fatty Acids (VFA) in Sheep
A VFA mixture solution containing acetate, propionate and butyrate (the molar ratio of acetate, propionate and n-butyrate =61.7:24.3:14.0) was infused into the rumen at various rates (53.5, 107 and 214μmol kg-1 min-1) over 6h to examine the effects on basal and growth hormone-releasing factor (GRF,...
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| Veröffentlicht in: | Endocrine Journal 1997, Vol.44(1), pp.133-140 |
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| creator | MATSUNAGA, NOBUYOSHI GOKA, TAISEI NAM, KI TAEG ODA, SHINICHI OHNEDA, AKIRA SASAKI, YASUYUKI |
| description | A VFA mixture solution containing acetate, propionate and butyrate (the molar ratio of acetate, propionate and n-butyrate =61.7:24.3:14.0) was infused into the rumen at various rates (53.5, 107 and 214μmol kg-1 min-1) over 6h to examine the effects on basal and growth hormone-releasing factor (GRF, 0.25μg kg-1)-induced increase in secretion of GH, insulin, glucagon and somatostatin (SRIF) in five castrated male sheep. Intraruminal infusion of the VFA mixture into the 18-h-fasted animals at the rates of 53.5, 107 and 214μmol kg-1 min-1 finally raised the total intraruminal VFA concentration from 91.4 to 100.2 (P>0.05), 175.9 (P |
| doi_str_mv | 10.1507/endocrj.44.133 |
| format | Article |
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Intraruminal infusion of the VFA mixture into the 18-h-fasted animals at the rates of 53.5, 107 and 214μmol kg-1 min-1 finally raised the total intraruminal VFA concentration from 91.4 to 100.2 (P>0.05), 175.9 (P<0.05) and 234.5 (P<0.05) mmoll-1, respectively. A preliminary experiment showed that an infusion rate of 107μmol kg-1 min-1 mimics the postprandial increase in ruminal VFA. The basal plasma GH concentrations (2 to 4h after the start of VFA infusion) and the area under the profiles for GH release in response to the intravenous GRF injection, which was done 4h after the start of VFA infusion, were significantly decreased by the VFA infusion rates of 107 and 214μmol kg-1 min-1. Furthermore, the VFA infusion noticeably increased basal plasma concentrations of insulin, but it scarcely changed the basal levels of glucagon, SRIF and glucose. From these results we conclude that an increase in the ruminal VFA concentration, even within the physiological range, would suppress GH secretion from the ovine anterior pituitary, and that the postprandial rise in the ruminal VFA concentration may be one of the factors normally suppressing GH secretion in sheep.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.44.133</identifier><identifier>PMID: 9152626</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Animals ; Blood Glucose - analysis ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Dose-Response Relationship, Drug ; Fatty Acids, Volatile - administration & dosage ; Fatty Acids, Volatile - metabolism ; Fatty Acids, Volatile - pharmacology ; GH-releasing factor ; Glucagon - blood ; Glucagon - drug effects ; Glucagon - metabolism ; Growth Hormone - drug effects ; Growth Hormone - metabolism ; Growth Hormone-Releasing Hormone - administration & dosage ; Growth Hormone-Releasing Hormone - drug effects ; Growth Hormone-Releasing Hormone - pharmacology ; Injections, Intravenous ; Insulin - blood ; Insulin - metabolism ; Male ; Rumen - chemistry ; Rumen - metabolism ; Sheep ; Somatostatin - blood ; Somatostatin - drug effects ; Somatostatin - metabolism ; Time Factors ; Volatile fatty acids</subject><ispartof>Endocrine Journal, 1997, Vol.44(1), pp.133-140</ispartof><rights>The Japan Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9152626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MATSUNAGA, NOBUYOSHI</creatorcontrib><creatorcontrib>GOKA, TAISEI</creatorcontrib><creatorcontrib>NAM, KI TAEG</creatorcontrib><creatorcontrib>ODA, SHINICHI</creatorcontrib><creatorcontrib>OHNEDA, AKIRA</creatorcontrib><creatorcontrib>SASAKI, YASUYUKI</creatorcontrib><title>Inhibition of GH Releasing Factor (GRF)-Induced GH Secretion by Intraruminal Infusion of Volatile Fatty Acids (VFA) in Sheep</title><title>Endocrine Journal</title><addtitle>Endocr J</addtitle><description>A VFA mixture solution containing acetate, propionate and butyrate (the molar ratio of acetate, propionate and n-butyrate =61.7:24.3:14.0) was infused into the rumen at various rates (53.5, 107 and 214μmol kg-1 min-1) over 6h to examine the effects on basal and growth hormone-releasing factor (GRF, 0.25μg kg-1)-induced increase in secretion of GH, insulin, glucagon and somatostatin (SRIF) in five castrated male sheep. Intraruminal infusion of the VFA mixture into the 18-h-fasted animals at the rates of 53.5, 107 and 214μmol kg-1 min-1 finally raised the total intraruminal VFA concentration from 91.4 to 100.2 (P>0.05), 175.9 (P<0.05) and 234.5 (P<0.05) mmoll-1, respectively. A preliminary experiment showed that an infusion rate of 107μmol kg-1 min-1 mimics the postprandial increase in ruminal VFA. The basal plasma GH concentrations (2 to 4h after the start of VFA infusion) and the area under the profiles for GH release in response to the intravenous GRF injection, which was done 4h after the start of VFA infusion, were significantly decreased by the VFA infusion rates of 107 and 214μmol kg-1 min-1. Furthermore, the VFA infusion noticeably increased basal plasma concentrations of insulin, but it scarcely changed the basal levels of glucagon, SRIF and glucose. From these results we conclude that an increase in the ruminal VFA concentration, even within the physiological range, would suppress GH secretion from the ovine anterior pituitary, and that the postprandial rise in the ruminal VFA concentration may be one of the factors normally suppressing GH secretion in sheep.</description><subject>Animals</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fatty Acids, Volatile - administration & dosage</subject><subject>Fatty Acids, Volatile - metabolism</subject><subject>Fatty Acids, Volatile - pharmacology</subject><subject>GH-releasing factor</subject><subject>Glucagon - blood</subject><subject>Glucagon - drug effects</subject><subject>Glucagon - metabolism</subject><subject>Growth Hormone - drug effects</subject><subject>Growth Hormone - metabolism</subject><subject>Growth Hormone-Releasing Hormone - administration & dosage</subject><subject>Growth Hormone-Releasing Hormone - drug effects</subject><subject>Growth Hormone-Releasing Hormone - pharmacology</subject><subject>Injections, Intravenous</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>Male</subject><subject>Rumen - chemistry</subject><subject>Rumen - metabolism</subject><subject>Sheep</subject><subject>Somatostatin - blood</subject><subject>Somatostatin - drug effects</subject><subject>Somatostatin - metabolism</subject><subject>Time Factors</subject><subject>Volatile fatty acids</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1P4zAQxS20KygsV25IPq3gkGLHjj-OFaKlEtJKwHKNHHtCXaVOsZ1DJf74zdKIy4xG7zfv8B5CV5TMaUXkHQTX27idcz6njJ2gGWVcFbzi5AeaEU1VoXSlz9B5SltCGKs4O0WnmlalKMUMfa7Dxjc--z7gvsWrR_wMHZjkwzteGpv7iG9Wz8vbYh3cYMH9J17ARvj6aA54HXI0cdj5YLrxaIc0Wb31ncm-g9Em5wNeWO8SvnlbLm6xD_hlA7D_hX62pktwOe0L9Hf58Hr_WDz9Wa3vF0_FlokqF5wKV1WcKiFpI1stFaNSWlCqtYJSaXVZCtFYxzS3ZUMY4cw0SlPnpFVMsQv0--i7j_3HACnXO58sdJ0J0A-plppQIggdwesJHJoduHof_c7EQz3FNeqro75N2bzDt25i9raDeiqDas1qzmt6HGMv34TdmDhi7B9eh4Rm</recordid><startdate>19970201</startdate><enddate>19970201</enddate><creator>MATSUNAGA, NOBUYOSHI</creator><creator>GOKA, TAISEI</creator><creator>NAM, KI TAEG</creator><creator>ODA, SHINICHI</creator><creator>OHNEDA, AKIRA</creator><creator>SASAKI, YASUYUKI</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19970201</creationdate><title>Inhibition of GH Releasing Factor (GRF)-Induced GH Secretion by Intraruminal Infusion of Volatile Fatty Acids (VFA) in Sheep</title><author>MATSUNAGA, NOBUYOSHI ; GOKA, TAISEI ; NAM, KI TAEG ; ODA, SHINICHI ; OHNEDA, AKIRA ; SASAKI, YASUYUKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j365t-416d55418671b7f9783177ce88fc6117c92266bcd394c2b03043ab891dd7c8383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Blood Glucose - analysis</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fatty Acids, Volatile - administration & dosage</topic><topic>Fatty Acids, Volatile - metabolism</topic><topic>Fatty Acids, Volatile - pharmacology</topic><topic>GH-releasing factor</topic><topic>Glucagon - blood</topic><topic>Glucagon - drug effects</topic><topic>Glucagon - metabolism</topic><topic>Growth Hormone - drug effects</topic><topic>Growth Hormone - metabolism</topic><topic>Growth Hormone-Releasing Hormone - administration & dosage</topic><topic>Growth Hormone-Releasing Hormone - drug effects</topic><topic>Growth Hormone-Releasing Hormone - pharmacology</topic><topic>Injections, Intravenous</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>Male</topic><topic>Rumen - chemistry</topic><topic>Rumen - metabolism</topic><topic>Sheep</topic><topic>Somatostatin - blood</topic><topic>Somatostatin - drug effects</topic><topic>Somatostatin - metabolism</topic><topic>Time Factors</topic><topic>Volatile fatty acids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MATSUNAGA, NOBUYOSHI</creatorcontrib><creatorcontrib>GOKA, TAISEI</creatorcontrib><creatorcontrib>NAM, KI TAEG</creatorcontrib><creatorcontrib>ODA, SHINICHI</creatorcontrib><creatorcontrib>OHNEDA, AKIRA</creatorcontrib><creatorcontrib>SASAKI, YASUYUKI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MATSUNAGA, NOBUYOSHI</au><au>GOKA, TAISEI</au><au>NAM, KI TAEG</au><au>ODA, SHINICHI</au><au>OHNEDA, AKIRA</au><au>SASAKI, YASUYUKI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of GH Releasing Factor (GRF)-Induced GH Secretion by Intraruminal Infusion of Volatile Fatty Acids (VFA) in Sheep</atitle><jtitle>Endocrine Journal</jtitle><addtitle>Endocr J</addtitle><date>1997-02-01</date><risdate>1997</risdate><volume>44</volume><issue>1</issue><spage>133</spage><epage>140</epage><pages>133-140</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>A VFA mixture solution containing acetate, propionate and butyrate (the molar ratio of acetate, propionate and n-butyrate =61.7:24.3:14.0) was infused into the rumen at various rates (53.5, 107 and 214μmol kg-1 min-1) over 6h to examine the effects on basal and growth hormone-releasing factor (GRF, 0.25μg kg-1)-induced increase in secretion of GH, insulin, glucagon and somatostatin (SRIF) in five castrated male sheep. Intraruminal infusion of the VFA mixture into the 18-h-fasted animals at the rates of 53.5, 107 and 214μmol kg-1 min-1 finally raised the total intraruminal VFA concentration from 91.4 to 100.2 (P>0.05), 175.9 (P<0.05) and 234.5 (P<0.05) mmoll-1, respectively. A preliminary experiment showed that an infusion rate of 107μmol kg-1 min-1 mimics the postprandial increase in ruminal VFA. The basal plasma GH concentrations (2 to 4h after the start of VFA infusion) and the area under the profiles for GH release in response to the intravenous GRF injection, which was done 4h after the start of VFA infusion, were significantly decreased by the VFA infusion rates of 107 and 214μmol kg-1 min-1. Furthermore, the VFA infusion noticeably increased basal plasma concentrations of insulin, but it scarcely changed the basal levels of glucagon, SRIF and glucose. From these results we conclude that an increase in the ruminal VFA concentration, even within the physiological range, would suppress GH secretion from the ovine anterior pituitary, and that the postprandial rise in the ruminal VFA concentration may be one of the factors normally suppressing GH secretion in sheep.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>9152626</pmid><doi>10.1507/endocrj.44.133</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Blood Glucose - analysis Blood Glucose - drug effects Blood Glucose - metabolism Dose-Response Relationship, Drug Fatty Acids, Volatile - administration & dosage Fatty Acids, Volatile - metabolism Fatty Acids, Volatile - pharmacology GH-releasing factor Glucagon - blood Glucagon - drug effects Glucagon - metabolism Growth Hormone - drug effects Growth Hormone - metabolism Growth Hormone-Releasing Hormone - administration & dosage Growth Hormone-Releasing Hormone - drug effects Growth Hormone-Releasing Hormone - pharmacology Injections, Intravenous Insulin - blood Insulin - metabolism Male Rumen - chemistry Rumen - metabolism Sheep Somatostatin - blood Somatostatin - drug effects Somatostatin - metabolism Time Factors Volatile fatty acids |
| title | Inhibition of GH Releasing Factor (GRF)-Induced GH Secretion by Intraruminal Infusion of Volatile Fatty Acids (VFA) in Sheep |
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