Glucocorticoid- and mineralocorticoid receptors in microglial cells: The two receptors mediate differential effects of corticosteroids

Effects of steroid hormones on the regulation of function and morphology of microglial cells were investigated using the cultured cells isolated from forebrain of newborn rats. Cortisol, corticosterone, and aldosterone at 100 nM caused a strong shrinkage of microglial cells cultured in a serum‐suppl...

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Veröffentlicht in:	Glia 1997-05, Vol.20 (1), p.23-37
Hauptverfasser:	Tanaka, Junya, Fujita, Hiroko, Matsuda, Seiji, Toku, Kazuko, Sakanaka, Masahiro, Maeda, Nobuji
Format:	Artikel
Sprache:	eng
Schlagworte:	acid phosphatase Adrenal Cortex Hormones - pharmacology Aldosterone - pharmacology Androstanols - pharmacology Animals Animals, Newborn Biological and medical sciences Cells, Cultured Cholesterol - pharmacology Corticosterone - pharmacology Culture Media Culture Media, Serum-Free Dehydroepiandrosterone - pharmacology Dexamethasone - pharmacology Estradiol - pharmacology Fundamental and applied biological sciences. Psychology GM-CSF Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Hydrocortisone - pharmacology IL-3 Isolated neuron and nerve. Neuroglia lysosome Microglia - cytology Microglia - drug effects Microglia - physiology Mifepristone - pharmacology nitric oxide Pregnenolone - pharmacology Proliferating Cell Nuclear Antigen - analysis proliferation Prosencephalon - cytology Prosencephalon - physiology Rats Receptors, Glucocorticoid - physiology Receptors, Mineralocorticoid - physiology Testosterone - pharmacology Vertebrates: nervous system and sense organs
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