Enhancement of axon growth by detergent-extracted nerve grafts

The immunogenicity of nerve allografts is responsible for their rejection. We have developed a method for preparing cell-free nerve grafts using lysophosphatidylcholine to remove cells, axons, and myelin sheaths. The remaining intact nerve extracellular matrix is the extracted nerve graft (eNG). Cul...

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Veröffentlicht in:	Transplantation 1997-05, Vol.63 (9), p.1210-1215
Hauptverfasser:	DUMONT, C. E, HENTZ, V. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - physiology Biological and medical sciences Cells, Cultured Cranial nerves. Peripheral nerves. Autonomic nervous system Detergents - pharmacology Graft Enhancement, Immunologic - methods Lysophosphatidylcholines - pharmacology Male Medical sciences Microinjections Muscle, Skeletal - anatomy & histology Muscle, Skeletal - innervation Nerve Regeneration Neurosurgery Organ Size - physiology Peroneal Nerve - surgery Rats Rats, Inbred F344 Schwann Cells - cytology Schwann Cells - transplantation Sciatic Nerve - cytology Sciatic Nerve - drug effects Sciatic Nerve - transplantation Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transplantation Conditioning - methods Transplantation, Homologous
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