aex-3 Encodes a Novel Regulator of Presynaptic Activity in C. elegans
C. elegans aex-3mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission. aex-3mutations also show strong genetic interactions with mutations in unc-31and unc-64, two other genes implicated in synaptic transmission. Physiological and pharmacological studies...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 1997-04, Vol.18 (4), p.613-622 |
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| creator | Iwasaki, Kouichi Staunton, Jane Saifee, Owais Nonet, Michael Thomas, James H |
| description | C. elegans
aex-3mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission.
aex-3mutations also show strong genetic interactions with mutations in
unc-31and
unc-64, two other genes implicated in synaptic transmission. Physiological and pharmacological studies indicate that
aex-3defects are presynaptic. In
aex-3mutants, the synaptic vesicle–associated RAB-3 protein aberrantly accumulates in neuronal cell bodies and is reduced in synapse-rich axons. This localization defect is specific to RAB-3, since other synaptic proteins are localized normally in
aex-3mutants.
aex-3encodes a 1409 amino acid protein with strong homology to DENN, a human protein of unknown function. In C. elegans,
aex-3is expressed in all or nearly all neurons. These results suggest that AEX-3 is a novel regulator of presynaptic activity that interacts with RAB-3 to regulate synaptic vesicle release. |
| doi_str_mv | 10.1016/S0896-6273(00)80302-5 |
| format | Article |
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aex-3mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission.
aex-3mutations also show strong genetic interactions with mutations in
unc-31and
unc-64, two other genes implicated in synaptic transmission. Physiological and pharmacological studies indicate that
aex-3defects are presynaptic. In
aex-3mutants, the synaptic vesicle–associated RAB-3 protein aberrantly accumulates in neuronal cell bodies and is reduced in synapse-rich axons. This localization defect is specific to RAB-3, since other synaptic proteins are localized normally in
aex-3mutants.
aex-3encodes a 1409 amino acid protein with strong homology to DENN, a human protein of unknown function. In C. elegans,
aex-3is expressed in all or nearly all neurons. These results suggest that AEX-3 is a novel regulator of presynaptic activity that interacts with RAB-3 to regulate synaptic vesicle release.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/S0896-6273(00)80302-5</identifier><identifier>PMID: 9136770</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aldicarb - pharmacology ; Amino Acid Sequence ; Animals ; Behavior, Animal - physiology ; Caenorhabditis elegans - genetics ; Cholinesterase Inhibitors - pharmacology ; Chromosome Mapping ; Electrophysiology ; Genes ; GTP-Binding Proteins - metabolism ; Molecular Sequence Data ; Mutation ; Nervous System Physiological Phenomena ; Pharynx - innervation ; Presynaptic Terminals - physiology ; rab3 GTP-Binding Proteins ; Synapses - physiology ; Synaptic Transmission ; Tissue Distribution</subject><ispartof>Neuron (Cambridge, Mass.), 1997-04, Vol.18 (4), p.613-622</ispartof><rights>1997 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-b45c211e72741dfacdd21bfdff5df16c3d961fdbd57f298d2c87a61dae1845993</citedby><cites>FETCH-LOGICAL-c438t-b45c211e72741dfacdd21bfdff5df16c3d961fdbd57f298d2c87a61dae1845993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0896-6273(00)80302-5$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9136770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwasaki, Kouichi</creatorcontrib><creatorcontrib>Staunton, Jane</creatorcontrib><creatorcontrib>Saifee, Owais</creatorcontrib><creatorcontrib>Nonet, Michael</creatorcontrib><creatorcontrib>Thomas, James H</creatorcontrib><title>aex-3 Encodes a Novel Regulator of Presynaptic Activity in C. elegans</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>C. elegans
aex-3mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission.
aex-3mutations also show strong genetic interactions with mutations in
unc-31and
unc-64, two other genes implicated in synaptic transmission. Physiological and pharmacological studies indicate that
aex-3defects are presynaptic. In
aex-3mutants, the synaptic vesicle–associated RAB-3 protein aberrantly accumulates in neuronal cell bodies and is reduced in synapse-rich axons. This localization defect is specific to RAB-3, since other synaptic proteins are localized normally in
aex-3mutants.
aex-3encodes a 1409 amino acid protein with strong homology to DENN, a human protein of unknown function. In C. elegans,
aex-3is expressed in all or nearly all neurons. These results suggest that AEX-3 is a novel regulator of presynaptic activity that interacts with RAB-3 to regulate synaptic vesicle release.</description><subject>Aldicarb - pharmacology</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Chromosome Mapping</subject><subject>Electrophysiology</subject><subject>Genes</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Nervous System Physiological Phenomena</subject><subject>Pharynx - innervation</subject><subject>Presynaptic Terminals - physiology</subject><subject>rab3 GTP-Binding Proteins</subject><subject>Synapses - physiology</subject><subject>Synaptic Transmission</subject><subject>Tissue Distribution</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P4zAQhi3ECgq7PwHJJwSHwIyT2PEJoap8SIhdwe7Zcu0xMkqTYqcV_fcbaMWV0xze550ZPYydIFwgoLx8hkbLQgpVngGcN1CCKOo9NkHQqqhQ6302-UIO2VHOrwBY1RoP2IHGUioFEzaz9F6UfNa53lPmlj_2a2r5E72sWjv0ifeB_0mUN51dDtHxazfEdRw2PHZ8esGppRfb5Z_sR7Btpl-7ecz-3cz-Tu-Kh9-399Prh8JVZTMU86p2ApGUUBX6YJ33AufBh1D7gNKVXksMfu5rFYRuvHCNshK9JWzGx3V5zE63e5epf1tRHswiZkdtazvqV9koDdBIIb4FUZZNjQgjWG9Bl_qcEwWzTHFh08YgmA_P5tOz-ZBoAMynZ1OPvZPdgdV8Qf6rtRM75lfbnEYd60jJZBepc-RjIjcY38dvLvwHadaL6A</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Iwasaki, Kouichi</creator><creator>Staunton, Jane</creator><creator>Saifee, Owais</creator><creator>Nonet, Michael</creator><creator>Thomas, James H</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19970401</creationdate><title>aex-3 Encodes a Novel Regulator of Presynaptic Activity in C. elegans</title><author>Iwasaki, Kouichi ; Staunton, Jane ; Saifee, Owais ; Nonet, Michael ; Thomas, James H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-b45c211e72741dfacdd21bfdff5df16c3d961fdbd57f298d2c87a61dae1845993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Aldicarb - pharmacology</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Chromosome Mapping</topic><topic>Electrophysiology</topic><topic>Genes</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Nervous System Physiological Phenomena</topic><topic>Pharynx - innervation</topic><topic>Presynaptic Terminals - physiology</topic><topic>rab3 GTP-Binding Proteins</topic><topic>Synapses - physiology</topic><topic>Synaptic Transmission</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwasaki, Kouichi</creatorcontrib><creatorcontrib>Staunton, Jane</creatorcontrib><creatorcontrib>Saifee, Owais</creatorcontrib><creatorcontrib>Nonet, Michael</creatorcontrib><creatorcontrib>Thomas, James H</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwasaki, Kouichi</au><au>Staunton, Jane</au><au>Saifee, Owais</au><au>Nonet, Michael</au><au>Thomas, James H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>aex-3 Encodes a Novel Regulator of Presynaptic Activity in C. elegans</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>18</volume><issue>4</issue><spage>613</spage><epage>622</epage><pages>613-622</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>C. elegans
aex-3mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission.
aex-3mutations also show strong genetic interactions with mutations in
unc-31and
unc-64, two other genes implicated in synaptic transmission. Physiological and pharmacological studies indicate that
aex-3defects are presynaptic. In
aex-3mutants, the synaptic vesicle–associated RAB-3 protein aberrantly accumulates in neuronal cell bodies and is reduced in synapse-rich axons. This localization defect is specific to RAB-3, since other synaptic proteins are localized normally in
aex-3mutants.
aex-3encodes a 1409 amino acid protein with strong homology to DENN, a human protein of unknown function. In C. elegans,
aex-3is expressed in all or nearly all neurons. These results suggest that AEX-3 is a novel regulator of presynaptic activity that interacts with RAB-3 to regulate synaptic vesicle release.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9136770</pmid><doi>10.1016/S0896-6273(00)80302-5</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Open Access: Cell Press Free Archives; EZB Electronic Journals Library |
| subjects | Aldicarb - pharmacology Amino Acid Sequence Animals Behavior, Animal - physiology Caenorhabditis elegans - genetics Cholinesterase Inhibitors - pharmacology Chromosome Mapping Electrophysiology Genes GTP-Binding Proteins - metabolism Molecular Sequence Data Mutation Nervous System Physiological Phenomena Pharynx - innervation Presynaptic Terminals - physiology rab3 GTP-Binding Proteins Synapses - physiology Synaptic Transmission Tissue Distribution |
| title | aex-3 Encodes a Novel Regulator of Presynaptic Activity in C. elegans |
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