Selective fluorogenic derivatization of a peptide nucleic acid trimer with naphthalene-2,3-dicarboxaldehyde

The reversed-phase high-performance liquid chromatography of a Peptide Nucleic Acid (PNA) trimer has been studied after its preseparation fluorogenic derivatization with naphthalene-2,3-dicarboxaldehyde in the presence of cyanide (NDA/CN). Trace levels of the PNA trimer were determined in cell homog...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1997-04, Vol.15 (7), p.945-950
Hauptverfasser:	Nerurkar, Manoj M, Rose, Mark J, Stobaugh, John F, Borchardt, Ronald T
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Caco-2 Cells Chromatography, High Pressure Liquid General pharmacology Humans Indicators and Reagents Medical sciences Naphthalenes NDA/CN Nucleic Acids - analysis Nucleic Acids - chemistry Peptide nucleic acids Peptides - analysis Peptides - chemistry Pharmacology. Drug treatments Polymers - analysis Polymers - chemistry Reproducibility of Results Spectrometry, Fluorescence
Online-Zugang:	Volltext
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