Effect of amantadine hydrochloride on symptoms of frontal lobe dysfunction in brain injury: case studies and review
Symptoms consistent with dysfunction of the frontal lobes can occur following traumatic brain injury (TBI) or other types of acquired brain injury (stroke, aneurysm). These symptoms can include problems with short-term memory, attention, planning, problem solving, impulsivity, disinhibition, poor mo...
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| Veröffentlicht in: | The journal of neuropsychiatry and clinical neurosciences 1997, Vol.9 (2), p.222-230 |
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| container_title | The journal of neuropsychiatry and clinical neurosciences |
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| creator | Kraus, M F Maki, P M |
| description | Symptoms consistent with dysfunction of the frontal lobes can occur
following traumatic brain injury (TBI) or other types of acquired brain
injury (stroke, aneurysm). These symptoms can include problems with
short-term memory, attention, planning, problem solving, impulsivity,
disinhibition, poor motivation, and other behavioral and cognitive deficits
("frontal lobe syndrome"). These symptoms may respond to certain drugs,
such as dopaminergic agents. This case series describes results of using
amantadine in 7 patients with this type of symptom profile (6 with TBI, 1
with meningitis following sinus surgery). Patients received
neuropsychiatric examinations and serial neuropsychological testing. All
patients showed some degree of positive response. One had side effects that
resolved upon discontinuation of drug. The rationale for using
dopaminergics is discussed, and pertinent literature is reviewed. |
| doi_str_mv | 10.1176/jnp.9.2.222 |
| format | Article |
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following traumatic brain injury (TBI) or other types of acquired brain
injury (stroke, aneurysm). These symptoms can include problems with
short-term memory, attention, planning, problem solving, impulsivity,
disinhibition, poor motivation, and other behavioral and cognitive deficits
("frontal lobe syndrome"). These symptoms may respond to certain drugs,
such as dopaminergic agents. This case series describes results of using
amantadine in 7 patients with this type of symptom profile (6 with TBI, 1
with meningitis following sinus surgery). Patients received
neuropsychiatric examinations and serial neuropsychological testing. All
patients showed some degree of positive response. One had side effects that
resolved upon discontinuation of drug. The rationale for using
dopaminergics is discussed, and pertinent literature is reviewed.</description><identifier>ISSN: 0895-0172</identifier><identifier>EISSN: 1545-7222</identifier><identifier>DOI: 10.1176/jnp.9.2.222</identifier><identifier>PMID: 9144101</identifier><language>eng</language><publisher>United States: American Psychiatric Publishing</publisher><subject>Adult ; Amantadine - administration & dosage ; Amantadine - therapeutic use ; Brain Injuries - complications ; Brain Injuries - physiopathology ; Cognition Disorders - diagnosis ; Cognition Disorders - drug therapy ; Cognition Disorders - etiology ; Dopamine Agents - administration & dosage ; Dopamine Agents - therapeutic use ; Female ; Frontal Lobe - physiopathology ; Humans ; Male ; Middle Aged ; Neuropsychological Tests</subject><ispartof>The journal of neuropsychiatry and clinical neurosciences, 1997, Vol.9 (2), p.222-230</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a317t-56afffb769f4896137628fbe6b182b78b2123b5e5bcf0a0a20d7e45a63223c803</citedby><cites>FETCH-LOGICAL-a317t-56afffb769f4896137628fbe6b182b78b2123b5e5bcf0a0a20d7e45a63223c803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/jnp.9.2.222$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/jnp.9.2.222$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,776,780,2842,2846,4010,21605,21606,21607,21608,27900,27901,27902,77534,77535,77537,77542</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9144101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kraus, M F</creatorcontrib><creatorcontrib>Maki, P M</creatorcontrib><title>Effect of amantadine hydrochloride on symptoms of frontal lobe dysfunction in brain injury: case studies and review</title><title>The journal of neuropsychiatry and clinical neurosciences</title><addtitle>J Neuropsychiatry Clin Neurosci</addtitle><description>Symptoms consistent with dysfunction of the frontal lobes can occur
following traumatic brain injury (TBI) or other types of acquired brain
injury (stroke, aneurysm). These symptoms can include problems with
short-term memory, attention, planning, problem solving, impulsivity,
disinhibition, poor motivation, and other behavioral and cognitive deficits
("frontal lobe syndrome"). These symptoms may respond to certain drugs,
such as dopaminergic agents. This case series describes results of using
amantadine in 7 patients with this type of symptom profile (6 with TBI, 1
with meningitis following sinus surgery). Patients received
neuropsychiatric examinations and serial neuropsychological testing. All
patients showed some degree of positive response. One had side effects that
resolved upon discontinuation of drug. The rationale for using
dopaminergics is discussed, and pertinent literature is reviewed.</description><subject>Adult</subject><subject>Amantadine - administration & dosage</subject><subject>Amantadine - therapeutic use</subject><subject>Brain Injuries - complications</subject><subject>Brain Injuries - physiopathology</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - drug therapy</subject><subject>Cognition Disorders - etiology</subject><subject>Dopamine Agents - administration & dosage</subject><subject>Dopamine Agents - therapeutic use</subject><subject>Female</subject><subject>Frontal Lobe - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><issn>0895-0172</issn><issn>1545-7222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1LwzAYxoMoc05PnoWcRJDOJP1I603G_ICBFz2HpH3DMtqkJq3S_96MDU-e3geeHw-8P4SuKVlSyouHne2X1ZItGWMnaE7zLE94zKdoTsoqTwjl7BxdhLAjhLC0yGZoVtEso4TOUVhrDfWAncayk3aQjbGAt1PjXb1tnTcNYGdxmLp-cF3Yc9q7yLW4dQpwMwU92nowETIWKy_NPuxGPz3iWgbAYRgbAwFL22AP3wZ-LtGZlm2Aq-NdoM_n9cfqNdm8v7ytnjaJTCkfkryQWmvFi0pnZVXQlBes1AoKRUumeKkYZanKIVe1JpJIRhoOWS6LlLG0Lkm6QLeH3d67rxHCIDoTamhbacGNQfCKkDLLeATvD2DtXQgetOi96aSfBCVir1hExaISTEStkb45zo6qg-aPPTqN_d2hl31vxM6N3sYv_536BQZkhis</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Kraus, M F</creator><creator>Maki, P M</creator><general>American Psychiatric Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Effect of amantadine hydrochloride on symptoms of frontal lobe dysfunction in brain injury: case studies and review</title><author>Kraus, M F ; Maki, P M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a317t-56afffb769f4896137628fbe6b182b78b2123b5e5bcf0a0a20d7e45a63223c803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Amantadine - administration & dosage</topic><topic>Amantadine - therapeutic use</topic><topic>Brain Injuries - complications</topic><topic>Brain Injuries - physiopathology</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - drug therapy</topic><topic>Cognition Disorders - etiology</topic><topic>Dopamine Agents - administration & dosage</topic><topic>Dopamine Agents - therapeutic use</topic><topic>Female</topic><topic>Frontal Lobe - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kraus, M F</creatorcontrib><creatorcontrib>Maki, P M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of neuropsychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kraus, M F</au><au>Maki, P M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of amantadine hydrochloride on symptoms of frontal lobe dysfunction in brain injury: case studies and review</atitle><jtitle>The journal of neuropsychiatry and clinical neurosciences</jtitle><addtitle>J Neuropsychiatry Clin Neurosci</addtitle><date>1997</date><risdate>1997</risdate><volume>9</volume><issue>2</issue><spage>222</spage><epage>230</epage><pages>222-230</pages><issn>0895-0172</issn><eissn>1545-7222</eissn><abstract>Symptoms consistent with dysfunction of the frontal lobes can occur
following traumatic brain injury (TBI) or other types of acquired brain
injury (stroke, aneurysm). These symptoms can include problems with
short-term memory, attention, planning, problem solving, impulsivity,
disinhibition, poor motivation, and other behavioral and cognitive deficits
("frontal lobe syndrome"). These symptoms may respond to certain drugs,
such as dopaminergic agents. This case series describes results of using
amantadine in 7 patients with this type of symptom profile (6 with TBI, 1
with meningitis following sinus surgery). Patients received
neuropsychiatric examinations and serial neuropsychological testing. All
patients showed some degree of positive response. One had side effects that
resolved upon discontinuation of drug. The rationale for using
dopaminergics is discussed, and pertinent literature is reviewed.</abstract><cop>United States</cop><pub>American Psychiatric Publishing</pub><pmid>9144101</pmid><doi>10.1176/jnp.9.2.222</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0895-0172 |
| ispartof | The journal of neuropsychiatry and clinical neurosciences, 1997, Vol.9 (2), p.222-230 |
| issn | 0895-0172 1545-7222 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79008447 |
| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); EZB-FREE-00999 freely available EZB journals; Psychiatry Legacy Collection Online Journals 1844-1996 |
| subjects | Adult Amantadine - administration & dosage Amantadine - therapeutic use Brain Injuries - complications Brain Injuries - physiopathology Cognition Disorders - diagnosis Cognition Disorders - drug therapy Cognition Disorders - etiology Dopamine Agents - administration & dosage Dopamine Agents - therapeutic use Female Frontal Lobe - physiopathology Humans Male Middle Aged Neuropsychological Tests |
| title | Effect of amantadine hydrochloride on symptoms of frontal lobe dysfunction in brain injury: case studies and review |
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