Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms

The recently cloned gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia (A-T) is involved in DNA damage response at different cell cycle checkpoints and also appears to have a wider role in signal transduction. Antibodies prepared against peptides from the predicted protein sequen...

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Veröffentlicht in:	Oncogene 1997-04, Vol.14 (16), p.1911-1921
Hauptverfasser:	WATTERS, D, KUM KUM KHANNA, ZHANG, N, FARRELL, A, RAMSAY, J, GATTI, R, LAVIN, M, BEAMISH, H, BIRRELL, G, SPRING, K, KEDAR, P, GATEI, M, STENZEL, D, HOBSON, K, KOZLOV, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Antibodies Ataxia Ataxia Telangiectasia - genetics Ataxia telangiectasia mutated protein Ataxia Telangiectasia Mutated Proteins Biological and medical sciences Blotting, Western Cell cycle Cell Cycle Proteins Cell Line, Transformed Cell Nucleus - ultrastructure Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...) Cloning, Molecular Cytoplasmic Granules - ultrastructure Deoxyribonucleic acid DNA DNA damage DNA-Binding Proteins Enzyme-Linked Immunosorbent Assay Genetic disorders Herpesvirus 4, Human Homozygote Homozygotes Humans Immunofluorescence Lymphocytes T Medical genetics Medical sciences Microscopy, Immunoelectron Microsomes - ultrastructure Open Reading Frames Organelles - metabolism Organelles - ultrastructure p53 Protein Phenotypes Point Mutation Protein Biosynthesis Protein-Serine-Threonine Kinases Proteins Proteins - analysis Radiation Recombinant Proteins - analysis Recombinant Proteins - biosynthesis Sequence Deletion Signal transduction Tumor Suppressor Protein p53 - analysis Tumor Suppressor Proteins
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