Pamidronate and Metastatic Breast Cancer

Pamidronate and Metastatic Breast Cancer

To the Editor: I am disturbed by the design of the trial reported by Hortobagyi et al. (Dec. 12 issue). 1 The standard of care for painful lytic metastases is radiation therapy or surgery, especially for lesions involving a risk of pathologic fracture. 2 These treatments are extremely effective if i...

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Veröffentlicht in:The New England journal of medicine 1997-05, Vol.336 (22), p.1609-1610
1. Verfasser: Kao, G
Format: Artikel
Sprache:eng
Schlagworte:
Bone Neoplasms - secondary
Bone Neoplasms - therapy
Breast Neoplasms - pathology
Diphosphonates - therapeutic use
Female
Humans
Pain Management
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container_title The New England journal of medicine
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creator Kao, G
description To the Editor: I am disturbed by the design of the trial reported by Hortobagyi et al. (Dec. 12 issue). 1 The standard of care for painful lytic metastases is radiation therapy or surgery, especially for lesions involving a risk of pathologic fracture. 2 These treatments are extremely effective if implemented in a timely manner. In large series, a rate of pain relief approaching 90 percent has been reported for radiation therapy, 3 and surgery usually results in prompt relief as well. 4 With such effective treatments readily available, it is arguably unethical to have a placebo arm in the trial; the two arms . . .
doi_str_mv 10.1056/NEJM199705293362215
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine
subjects Bone Neoplasms - secondary
Bone Neoplasms - therapy
Breast Neoplasms - pathology
Diphosphonates - therapeutic use
Female
Humans
Pain Management
title Pamidronate and Metastatic Breast Cancer
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