Potency Comparison of Peptidomimetic Inhibitors against HIV-1 and HIV-2 Proteinases: Design of Equipotent Lead Compounds

HIV-1 and HIV-2 proteinases (PR) are responsible for the processing of viral polyproteins, a step that is crucial for the formation of infectious virus particles. PR represents one of the most important targets for antiviral chemotherapy. Inhibitors of HIV-1 PR usually exhibit a 10- to 100-fold weak...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1997-05, Vol.341 (1), p.62-69
Hauptverfasser:	Weber, Jan, Majer, Pavel, Litera, Jaroslav, Urban, Jan, Souček, Milan, Vondrášek, Jiřı́, Konvalinka, Jan, Novek, Petr, Sedláček, Juraj, Štrop, Petr, Kräusslich, Hans-Georg, Pichová, Iva
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Aspartic Acid Endopeptidases - metabolism Binding Sites Drug Design drug resistance enzyme kinetics Escherichia coli - genetics HIV Protease - metabolism HIV Protease Inhibitors - chemical synthesis HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacology HIV-1 proteinase HIV-2 proteinase Models, Molecular Molecular Structure Oligopeptides - chemical synthesis Oligopeptides - chemistry Oligopeptides - pharmacology peptide inhibitors subsite specificity
Online-Zugang:	Volltext
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