Effects of 5-HT1A receptor ligands in a modified Geller-Seifter conflict model in the rat
In a modified Geller-Seifter conflict procedure, rats were trained to lever-press for food under a multiple variable interval-fixed ratio (VI30: food; FR10: food + shock) schedule of reinforcement. The ability to antagonize response suppression in the punished period is considered a good predictor f...
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Veröffentlicht in: | European journal of pharmacology 1997-05, Vol.325 (2-3), p.121-128 |
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container_title | European journal of pharmacology |
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creator | KING, C. M. F GOMMANS, J JOORDENS, R. J. E HIJZEN, T. H MAES, R. A. A OLIVIER, B |
description | In a modified Geller-Seifter conflict procedure, rats were trained to lever-press for food under a multiple variable interval-fixed ratio (VI30: food; FR10: food + shock) schedule of reinforcement. The ability to antagonize response suppression in the punished period is considered a good predictor for anxiolytic activity. Chlordiazepoxide and alprazolam increased punished responding. The 5-HT1A receptor agonists flesinoxan (R(+)-N-[2[4-(2,3-dihydro-2-2-hydroxymethyl-1,4-benzodioxin-5-yl)- 1-piperazinyl]ethyl]-4-fluorobenzoamide; 0.1-10.0 mg/kg) and 8-OH-DPAT (8-hydroxy-2-(di-n-propyl-amino)tetralin; 0.03-0.5 mg/kg) significantly increased punished responding, supporting a role of the 5-HT1A receptor in anxiety. 8-OH-DPAT and flesinoxan also reduced unpunished responding. The anxiolytic effects of 8-OH-DPAT and flesinoxan could only be antagonized with a high dose (1.0 and 3.0 mg/kg respectively) of the 5-HT1A receptor antagonist WAY-100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride). All doses of WAY-100635 antagonized the 5-HT1A-induced effects on unpunished responding. The dissimilarity in dose-response curve of WAY-100635 on punished and unpunished behaviour poses questions about the mediation of these effects. |
doi_str_mv | 10.1016/S0014-2999(97)00114-3 |
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M. F ; GOMMANS, J ; JOORDENS, R. J. E ; HIJZEN, T. H ; MAES, R. A. A ; OLIVIER, B</creator><creatorcontrib>KING, C. M. F ; GOMMANS, J ; JOORDENS, R. J. E ; HIJZEN, T. H ; MAES, R. A. A ; OLIVIER, B</creatorcontrib><description>In a modified Geller-Seifter conflict procedure, rats were trained to lever-press for food under a multiple variable interval-fixed ratio (VI30: food; FR10: food + shock) schedule of reinforcement. The ability to antagonize response suppression in the punished period is considered a good predictor for anxiolytic activity. Chlordiazepoxide and alprazolam increased punished responding. The 5-HT1A receptor agonists flesinoxan (R(+)-N-[2[4-(2,3-dihydro-2-2-hydroxymethyl-1,4-benzodioxin-5-yl)- 1-piperazinyl]ethyl]-4-fluorobenzoamide; 0.1-10.0 mg/kg) and 8-OH-DPAT (8-hydroxy-2-(di-n-propyl-amino)tetralin; 0.03-0.5 mg/kg) significantly increased punished responding, supporting a role of the 5-HT1A receptor in anxiety. 8-OH-DPAT and flesinoxan also reduced unpunished responding. The anxiolytic effects of 8-OH-DPAT and flesinoxan could only be antagonized with a high dose (1.0 and 3.0 mg/kg respectively) of the 5-HT1A receptor antagonist WAY-100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride). All doses of WAY-100635 antagonized the 5-HT1A-induced effects on unpunished responding. The dissimilarity in dose-response curve of WAY-100635 on punished and unpunished behaviour poses questions about the mediation of these effects.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/S0014-2999(97)00114-3</identifier><identifier>PMID: 9163558</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology ; Alprazolam - pharmacology ; Animals ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Biological and medical sciences ; Chlordiazepoxide - pharmacology ; Conflict (Psychology) ; Ligands ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Piperazines - pharmacology ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Pyridines - pharmacology ; Quinpirole - pharmacology ; Rats ; Rats, Wistar ; Receptors, Serotonin - drug effects ; Receptors, Serotonin - physiology ; Receptors, Serotonin, 5-HT1 ; Serotonin Antagonists - pharmacology ; Serotonin Receptor Agonists - pharmacology</subject><ispartof>European journal of pharmacology, 1997-05, Vol.325 (2-3), p.121-128</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c265t-c2e6464b1b51f29b51e2174cfda78392d214603242b3c523d36a8b54b9f252303</citedby><cites>FETCH-LOGICAL-c265t-c2e6464b1b51f29b51e2174cfda78392d214603242b3c523d36a8b54b9f252303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2675018$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9163558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KING, C. M. F</creatorcontrib><creatorcontrib>GOMMANS, J</creatorcontrib><creatorcontrib>JOORDENS, R. J. E</creatorcontrib><creatorcontrib>HIJZEN, T. H</creatorcontrib><creatorcontrib>MAES, R. A. A</creatorcontrib><creatorcontrib>OLIVIER, B</creatorcontrib><title>Effects of 5-HT1A receptor ligands in a modified Geller-Seifter conflict model in the rat</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>In a modified Geller-Seifter conflict procedure, rats were trained to lever-press for food under a multiple variable interval-fixed ratio (VI30: food; FR10: food + shock) schedule of reinforcement. The ability to antagonize response suppression in the punished period is considered a good predictor for anxiolytic activity. Chlordiazepoxide and alprazolam increased punished responding. The 5-HT1A receptor agonists flesinoxan (R(+)-N-[2[4-(2,3-dihydro-2-2-hydroxymethyl-1,4-benzodioxin-5-yl)- 1-piperazinyl]ethyl]-4-fluorobenzoamide; 0.1-10.0 mg/kg) and 8-OH-DPAT (8-hydroxy-2-(di-n-propyl-amino)tetralin; 0.03-0.5 mg/kg) significantly increased punished responding, supporting a role of the 5-HT1A receptor in anxiety. 8-OH-DPAT and flesinoxan also reduced unpunished responding. The anxiolytic effects of 8-OH-DPAT and flesinoxan could only be antagonized with a high dose (1.0 and 3.0 mg/kg respectively) of the 5-HT1A receptor antagonist WAY-100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride). All doses of WAY-100635 antagonized the 5-HT1A-induced effects on unpunished responding. The dissimilarity in dose-response curve of WAY-100635 on punished and unpunished behaviour poses questions about the mediation of these effects.</description><subject>8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology</subject><subject>Alprazolam - pharmacology</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Chlordiazepoxide - pharmacology</subject><subject>Conflict (Psychology)</subject><subject>Ligands</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperazines - pharmacology</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Pyridines - pharmacology</subject><subject>Quinpirole - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Serotonin - drug effects</subject><subject>Receptors, Serotonin - physiology</subject><subject>Receptors, Serotonin, 5-HT1</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Serotonin Receptor Agonists - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhoMotVZ_QiEHET2s5nN3cyyltkLBQ-vBU8hmJxrZ7tZke_Dfm37Qywwv88wkPAiNKXmmhOYvK0KoyJhS6lEVTymkxC_QkJaFykhB2SUanpFrdBPjDyFEKiYHaKBozqUsh-hz5hzYPuLOYZkt1nSCA1jY9l3Ajf8ybR2xb7HBm672zkON59A0ELIVeNdDwLZrXeNtvweg2bP9N-Bg-lt05UwT4e7UR-jjdbaeLrLl-_xtOllmluWyTxVykYuKVpI6plIFRgthXW2KkitWMypywplgFbeS8ZrnpqykqJRjKRI-Qg_Hu9vQ_e4g9nrjo02fNC10u6gLRYgQpUigPII2dDEGcHob_MaEP02J3ivVB6V670urQh-Uap72xqcHdtUG6vPWyWGa35_mJlrTuGBa6-MZY3khCS35P2B-fAg</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>KING, C. M. F</creator><creator>GOMMANS, J</creator><creator>JOORDENS, R. J. E</creator><creator>HIJZEN, T. H</creator><creator>MAES, R. A. A</creator><creator>OLIVIER, B</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>Effects of 5-HT1A receptor ligands in a modified Geller-Seifter conflict model in the rat</title><author>KING, C. M. F ; GOMMANS, J ; JOORDENS, R. J. E ; HIJZEN, T. H ; MAES, R. A. A ; OLIVIER, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c265t-c2e6464b1b51f29b51e2174cfda78392d214603242b3c523d36a8b54b9f252303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology</topic><topic>Alprazolam - pharmacology</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Chlordiazepoxide - pharmacology</topic><topic>Conflict (Psychology)</topic><topic>Ligands</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperazines - pharmacology</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Pyridines - pharmacology</topic><topic>Quinpirole - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Serotonin - drug effects</topic><topic>Receptors, Serotonin - physiology</topic><topic>Receptors, Serotonin, 5-HT1</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Serotonin Receptor Agonists - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KING, C. M. F</creatorcontrib><creatorcontrib>GOMMANS, J</creatorcontrib><creatorcontrib>JOORDENS, R. J. E</creatorcontrib><creatorcontrib>HIJZEN, T. H</creatorcontrib><creatorcontrib>MAES, R. A. A</creatorcontrib><creatorcontrib>OLIVIER, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KING, C. M. F</au><au>GOMMANS, J</au><au>JOORDENS, R. J. E</au><au>HIJZEN, T. H</au><au>MAES, R. A. A</au><au>OLIVIER, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 5-HT1A receptor ligands in a modified Geller-Seifter conflict model in the rat</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>325</volume><issue>2-3</issue><spage>121</spage><epage>128</epage><pages>121-128</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>In a modified Geller-Seifter conflict procedure, rats were trained to lever-press for food under a multiple variable interval-fixed ratio (VI30: food; FR10: food + shock) schedule of reinforcement. The ability to antagonize response suppression in the punished period is considered a good predictor for anxiolytic activity. Chlordiazepoxide and alprazolam increased punished responding. The 5-HT1A receptor agonists flesinoxan (R(+)-N-[2[4-(2,3-dihydro-2-2-hydroxymethyl-1,4-benzodioxin-5-yl)- 1-piperazinyl]ethyl]-4-fluorobenzoamide; 0.1-10.0 mg/kg) and 8-OH-DPAT (8-hydroxy-2-(di-n-propyl-amino)tetralin; 0.03-0.5 mg/kg) significantly increased punished responding, supporting a role of the 5-HT1A receptor in anxiety. 8-OH-DPAT and flesinoxan also reduced unpunished responding. The anxiolytic effects of 8-OH-DPAT and flesinoxan could only be antagonized with a high dose (1.0 and 3.0 mg/kg respectively) of the 5-HT1A receptor antagonist WAY-100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride). All doses of WAY-100635 antagonized the 5-HT1A-induced effects on unpunished responding. The dissimilarity in dose-response curve of WAY-100635 on punished and unpunished behaviour poses questions about the mediation of these effects.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>9163558</pmid><doi>10.1016/S0014-2999(97)00114-3</doi><tpages>8</tpages></addata></record> |
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subjects | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Alprazolam - pharmacology Animals Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Chlordiazepoxide - pharmacology Conflict (Psychology) Ligands Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Piperazines - pharmacology Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyridines - pharmacology Quinpirole - pharmacology Rats Rats, Wistar Receptors, Serotonin - drug effects Receptors, Serotonin - physiology Receptors, Serotonin, 5-HT1 Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology |
title | Effects of 5-HT1A receptor ligands in a modified Geller-Seifter conflict model in the rat |
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