Characterization of the Cytotoxic Activity of Nitric Oxide Generating N-Nitroso Compounds

The NO-generating abilities of aromatic N-nitroso compounds (nitrosoureas, nitrosamides and nitrosamines), and N-acetyl-S-nitroso-DL-penicillamine at ambient temperature were compared by employing the Griess reaction. 3, 3-Dibenzyl-1-(4-tolyl)-1-nitrosourea showed the greatest NO-generating ability...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1997/04/15, Vol.45(4), pp.595-598
Hauptverfasser:	TANNO, Masayuki, SUEYOSHI, Shoko, MIYATA, Naoki, UMEHARA, Kaoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Biological and medical sciences cytotoxicity Drug Screening Assays, Antitumor General aspects Medical sciences N-acetyl-S-nitroso-DL-penicillamine nitric oxide Nitric Oxide - metabolism nitrosamide nitrosamine Nitroso Compounds - metabolism Nitroso Compounds - pharmacology nitrosourea Pharmacology. Drug treatments Structure-Activity Relationship Tumor Cells, Cultured
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